Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Objectives: ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- A nd older-onset patients are still incompletely understood. Methods: We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: <65 years or ≥65 years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results: A total of 1338 patients with AAV were included: 66% had disease onset at <65 years of age [female 50%; mean age 48.4 years (s.d. 12.6)] and 34% had disease onset at ≥65 years [female 54%; mean age 73.6 years (s.d. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0.001). Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6 month VDI ≥5, compared with 7% of younger patients (P = 0.01). Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0.03]. Conclusion: Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients

War in Parliament: What a Digital Approach Can Add to the Study of Parliamentary History

With the digitization of the parliamentary proceedings (Handelingen der Staten Generaal), the structuring of this body of data, and the development of an advanced search engine, we can apply new methods of historical research. This contributes to a further promotion of the sophisticated use of quantitative data to enhance qualitative historical research. This article focuses on the Boerenpartij(Farmers’ Party), the first political party from the far right that entered Dutch parliament after the Second World War (WWII). The Boerenpartij is remembered as being stigmatized by the traditional political parties as "wrong" (" fout "), as National Socialism and its supporters were dubbed in the Netherlands. However, no systematic research has been conducted on the questions: in what way, how frequently and for what purpose these connections with the "wrong" past were made. With the available digitized data and the retrieval techniques offered by computer scientists it is now possible to answer these questions

Evaluation of the contraction of cutaneous wounds in wistar rats treated with Brazilian green propolis gel

In this work the effects of topic use of Brazilian green propolis gel in the contraction of wounds performed in rat s skin was evaluated. In ten female Wistar rats were done four wounds in dorsal region. Two wounds in each rat were treated daily with Brazilian green propolis gel during 10 days. The wounds were photographed daily, and the images were analyzed with ImageJ software, in order to measure wound areas and evaluate wound contraction. In the graphic analysis, treated group and control group had similar behavior, and both evolved for complete closure in 10th experimentation day. The wound clots fell down before in treated wounds. Green propolis in the gel formulation at 5% in topical use had not effect in the process of wound contraction. The macroscopic visualization of the contraction of wounds, by itself, does not seem to be a good indicator of the process of tissue repair.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Anales de Edafología y Agrobiología Tomo 29 Número 11-12

Profesor W. Kubiena.-- Aplicación de una nueva fórmula para el cálculo de la evaporación. Resultados para la zona centro de España, por J. Seco Santos y J. Garmendia lraundegui.-- Estudios sobre la brotadura de tubérculos de Cyperus sculentus Ten. var. aureus Richt. I. Acción de factores físicos y químicos, por R. Sánchez Tames y E. Vieitez.-- Acción comparativa del sulfato amónico -y el nitrato amónico cálcico en experiencias de campo con cultivos de trigo, remolacha, maíz y algodón, por M. Chaves Sánchez.-- Composición y propiedades fisicoquímicas de las arcillas de suelos del valle del Guadalquivir. J. Tierras negras andaluzas (vertisuelos), rendsinas y suelos pardo-calizos margosos vérticos (suelos margosos béticos), por F. Gonsález García y J. L. Pérez Rodríguez.-- Constitución y propiedades lisicoquímicas de las arcillas del valle del Guadalquivir. II. Suelos rojos mediterráneos, por F. González García, J. L. Pérez Rodríguez.-- Posibles interpretaciones de las estructuras de orientación en suelos, por J. Aguilar y M. Delgado.-- Estudio morfológico y microscópico ele los planosuelos sohre la raña de Guadalajara, por J. Pérez Mateos, F. Monturiol y J. Benayas.-- Nuevas orientaciones en las evoluciones de hierro durante el desarrollo de la hoja de limonero, por A. Ortuño, A. Hernansáez, M. Parra y O. Carpena. Suelos de Sierra Morena occidental. l. Descripción de perfiles y mineralogía de las arenas, por G. Paneque y N. Bellinfante.-- Fenómenos de periglaciarismo en paleosuelos de la meseta castellana, por T. Badorrey, A. Guerra y A. Finilla.-- Relaciones entre componentes minerales durante el crecimiento y desarrollo de la hoja de Citrus y Prunus, por A. Orti¡¡lo, M. Parra, A. Hernansáez y O. Carpena.-- Posibilidades de la lámina auxiliar azul de segundo orden en el estudio de la materia orgánica del suelo, por J. L. Guardiola y M. Delgado.-- Estudio sedimentológico de la zona aragonesa de la cuenca terciaria del valle del Ebro, por A. Pinilla y J. Catalán.—Notas. Próximo pleno del Patronato «Alonso de Herrera».-- Programa Intergubernamental e Interdisciplinario de la UNESCO «El hombre y la biosfera» sobre utilización racional y la conservación de los recursos naturales.-- Congreso Internacional de Mineralogía.-- XIV Conferencia Internacional de Economistas de la Agricultura.-- Invitación a profesores extranjeros.-- Visita del Dr. Boulaine.-- Reuniones, Congresos y Becas.-- Conferencia del profesor Nota.-- Conferencia del profesor Fitts.-- Creación de nuevas secciones y laboratorios.—Nombramientos Viaje del· Dr. J. A. Rausell Colom a los Estados Unidos.-- Seminario sobre Micromorfología del Suelo.-- BibliografíaPeer reviewe