4,078 research outputs found
Implication des modifications épigénétiques dans les cancers : développement de nouvelles approches thérapeutiques
Involvement of epigenetic modifications in cancers: development of new therapeutic approaches. Since cancer is the second cause of death after cardiovascular diseases in industrialized countries, it is urgent to elaborate new therapeutic approaches. Besides DNA mutations of essential genes, expansion of a cancer cell is frequently associated with epigenetic modifications i.e. not directly coded by the DNA sequence. Amongst epigenetic modifications, histones acetylation and DNA methylation are known to play important roles. In this context, a very promising anticancer therapy would be to correct epigenetic errors using compounds modulating histone acetylation and DNA methylation alone or in combination with other chemotherapeutic agents
Using a quantum dot as a high-frequency shot noise detector
We present the experimental realization of a Quantum Dot (QD) operating as a
high-frequency noise detector. Current fluctuations produced in a nearby
Quantum Point Contact (QPC) ionize the QD and induce transport through excited
states. The resulting transient current through the QD represents our detector
signal. We investigate its dependence on the QPC transmission and voltage bias.
We observe and explain a quantum threshold feature and a saturation in the
detector signal. This experimental and theoretical study is relevant in
understanding the backaction of a QPC used as a charge detector.Comment: 4 pages, 4 figures, accepted for publication in Physical Review
Letter
Single-shot readout of electron spin states in a quantum dot using spin-dependent tunnel rates
We present a method for reading out the spin state of electrons in a quantum
dot that is robust against charge noise and can be used even when the electron
temperature exceeds the energy splitting between the states. The spin states
are first correlated to different charge states using a spin dependence of the
tunnel rates. A subsequent fast measurement of the charge on the dot then
reveals the original spin state. We experimentally demonstrate the method by
performing read-out of the two-electron spin states, achieving a single-shot
visibility of more than 80%. We find very long triplet-to-singlet relaxation
times (up to several milliseconds), with a strong dependence on in-plane
magnetic field.Comment: 4 pages, 4 figure
Control and Detection of Singlet-Triplet Mixing in a Random Nuclear Field
We observe mixing between two-electron singlet and triplet states in a double
quantum dot, caused by interactions with nuclear spins in the host
semiconductor. This mixing is suppressed by applying a small magnetic field, or
by increasing the interdot tunnel coupling and thereby the singlet-triplet
splitting. Electron transport involving transitions between triplets and
singlets in turn polarizes the nuclei, resulting in striking bistabilities. We
extract from the fluctuating nuclear field a limitation on the time-averaged
spin coherence time T2* of 25 ns. Control of the electron-nuclear interaction
will therefore be crucial for the coherent manipulation of individual electron
spins.Comment: 4 pages main text, 4 figure
The Divine Clockwork: Bohr's correspondence principle and Nelson's stochastic mechanics for the atomic elliptic state
We consider the Bohr correspondence limit of the Schrodinger wave function
for an atomic elliptic state. We analyse this limit in the context of Nelson's
stochastic mechanics, exposing an underlying deterministic dynamical system in
which trajectories converge to Keplerian motion on an ellipse. This solves the
long standing problem of obtaining Kepler's laws of planetary motion in a
quantum mechanical setting. In this quantum mechanical setting, local mild
instabilities occur in the Kelperian orbit for eccentricities greater than
1/\sqrt{2} which do not occur classically.Comment: 42 pages, 18 figures, with typos corrected, updated abstract and
updated section 6.
Spin filling of a quantum dot derived from excited-state spectroscopy
We study the spin filling of a semiconductor quantum dot using excited-state
spectroscopy in a strong magnetic field. The field is oriented in the plane of
the two-dimensional electron gas in which the dot is electrostatically defined.
By combining the observation of Zeeman splitting with our knowledge of the
absolute number of electrons, we are able to determine the ground state spin
configuration for one to five electrons occupying the dot. For four electrons,
we find a ground state spin configuration with total spin S=1, in agreement
with Hund's first rule. The electron g-factor is observed to be independent of
magnetic field and electron number.Comment: 11 pages, 7 figures, submitted to New Journal of Physics, focus issue
on Solid State Quantum Informatio
The impact of reduction of doublet well spacing on the Net Present Value and the life time of fluvial Hot Sedimentary Aquifer doublets
This paper evaluates the impact of reduction of doublet well spacing, below the current West Netherlands Basin standard of 1000 to 1500 m, on the Net Present Value (NPV) and the life time of fluvial Hot Sedimentary Aquifer (HSA) doublets. First, a sensitivity analysis is used to show the possible advantage of such reduction on the NPV. The parameter value ranges are derived from West Netherlands Basin HSA doublet examples. The results indicate that a reduction of well spacing from 1400 to 1000 m could already influence NPV by up to 15%. This effect would be larger in more marginally economic HSA doublets compared to the West Netherlands Basin base case scenario. The possibility to reduce well spacing is supported by finite element production simulations, utilizing detailed facies architecture models. Furthermore, our results underline the necessity of detailed facies architecture models to assess the potential and risks of HSA doublets. This factor significantly affects doublet life time and net energy production of the doublet
Rigorous results on the local equilibrium kinetics of a protein folding model
A local equilibrium approach for the kinetics of a simplified protein folding
model, whose equilibrium thermodynamics is exactly solvable, was developed in
[M. Zamparo and A. Pelizzola, Phys. Rev. Lett. 97, 068106 (2006)]. Important
properties of this approach are (i) the free energy decreases with time, (ii)
the exact equilibrium is recovered in the infinite time limit, (iii) the
equilibration rate is an upper bound of the exact one and (iv) computational
complexity is polynomial in the number of variables. Moreover, (v) this method
is equivalent to another approximate approach to the kinetics: the path
probability method. In this paper we give detailed rigorous proofs for the
above results.Comment: 25 pages, RevTeX 4, to be published in JSTA
The influence of facies heterogeneity on the doublet performance in low-enthalpy geothermal sedimentary reservoirs
AbstractA three-dimensional model is used to study the influence of facies heterogeneity on energy production under different operational conditions of low-enthalpy geothermal doublet systems. Process-based facies modelling is utilised for the Nieuwerkerk sedimentary formation in the West Netherlands Basin to construct realistic reservoir models honouring geological heterogeneity. A finite element based reservoir simulator is used to model the fluid flow and heat transfer over time. A series of simulations is carried out to examine the effects of reservoir heterogeneity (Net-to-Gross ratio, N/G) on the life time and the energy recovery rate for different discharge rates and the production temperature (Tmin) above which the doublet is working. With respect to the results, we propose a design model to estimate the life time and energy recovery rate of the geothermal doublet. The life time is estimated as a function of N/G, Tmin and discharge rate, while the design model for the energy recovery rate is only a function of N/G and Tmin. Both life time and recovery show a positive relation with an increasing N/G. Further our results suggest that neglecting details of process-based facies modelling may lead to significant errors in predicting the life time of low-enthalpy geothermal systems for N/G values below 70%
Twin Binaries: Studies of Stability, Mass Transfer, and Coalescence
Motivated by suggestions that binaries with almost equal-mass components
("twins") play an important role in the formation of double neutron stars and
may be rather abundant among binaries, we study the stability of synchronized
close and contact binaries with identical components in circular orbits. In
particular, we investigate the dependency of the innermost stable circular
orbit on the core mass, and we study the coalescence of the binary that occurs
at smaller separations. For twin binaries composed of convective main-sequence
stars, subgiants, or giants with low mass cores (M_c <~0.15M, where M is the
mass of a component), a secular instability is reached during the contact
phase, accompanied by a dynamical mass transfer instability at the same or at a
slightly smaller orbital separation. Binaries that come inside this instability
limit transfer mass gradually from one component to the other and then coalesce
quickly as mass is lost through the outer Lagrangian points. For twin giant
binaries with moderate to massive cores (M_c >~0.15M), we find that stable
contact configurations exist at all separations down to the Roche limit, when
mass shedding through the outer Lagrangian points triggers a coalescence of the
envelopes and leaves the cores orbiting in a central tight binary. In addition
to the formation of binary neutron stars, we also discuss the implications of
our results for the production of planetary nebulae with double degenerate
central binaries.Comment: 17 pages, accepted to ApJ, final version includes discussion of
planetary nebulae with central binaries and a new figure about shock heating,
visualizations at http://webpub.allegheny.edu/employee/j/jalombar/movies
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