Diversity of Extended HLA-DRB1 Haplotypes in the Finnish Population

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Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria

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<i>TNF</i> blocks (<i>TNF_1– TNF_9</i>) and their frequencies (>1.0%).<i>HLA-DRB1</i> Haplotypes with <i>TNF, BTNL2</i> and <i>C4</i> Blocks.

<p><i>TNF</i> blocks (<i>TNF_1– TNF_9</i>) and their frequencies (>1.0%).<i>HLA-DRB1</i> Haplotypes with <i>TNF, BTNL2</i> and <i>C4</i> Blocks.</p

Two-locus haplotypes of HLA-DRB1 with C4 block (>1.0%)#.

#<p>Rare haplotypes were excluded.</p><p>Q0 = null allele.</p><p>InsCT = insertion in C4A gene.</p><p>f = frequency.</p

The Finnish <i>DRB1</i>∼<i>DQB1∼DPB1</i> haplotype frequencies (>1%) and comparison with other populations [41]–[46].

<p>f = frequency.</p><p>Total number of haplotypes in the population sample (Haplotypes/2n) shown in frequencies (f).</p

C4 blocks (C4_1– C4_6) and their frequencies (>1.0%).

<p>C4 blocks (C4_1– C4_6) and their frequencies (>1.0%).</p

Two-locus haplotypes of <i>HLA-DRB1</i> with <i>BTNL2</i> block (>1.0%)#.

<p>#Rare haplotypes were excluded.</p><p>f = frequency.</p

The Finnish HLA allele and phenotype frequencies.

<p>n = number of alleles/phenotypes.</p><p>Number of subjects = 150; Number of alleles = 300.</p><p>The phenotype or carrier positivity contains one or two copies of the variant.</p><p>HLA-DRB1*14∶01:01G stands for DRB1*14∶01:01 and DRB1*14∶54.</p><p># 2-digit resolution genotyping for HLA-DQB1*02 and *04.</p

Two-locus haplotypes of <i>HLA-DRB1</i> with <i>TNF</i> block (>1.0%)#.

<p>f = frequency.</p>#<p>Rare haplotypes were excluded from the analysis.</p

<i>HLA-DRB1</i> alleles in strong LD^# with <i>TNF, C4</i> and <i>BTNL2</i> blocks and <i>HLA-DQB1</i> and <i>-DPB1</i> alleles. LD is measured with D′/r².

#<p>Here the strong LD (D′>0.80) presented if r²>0.35 and P value <0.05.</p