Effects of etifoxine: Chemoreactome simulation

Etifoxine modulates GABAergic transmission and is used as an anxiolytic (anti-anxiety) medication. The indications for etifoxine use are anxiety, fear and inner tension.Objective: to simulate the biological properties of etifoxine. This simulation has been carried out for the first time.Material and methods. Reliable estimates of more than 2,500 biological activities were obtained for this molecule, which were compared with the reference drug lorazepam (benzodiazepine).Results and discussion. The data obtained from chemoreactome simulation may suggest that there are significant differences between the pharmacological effects of etifoxine and benzodiazepine in: 1) the selectivity of binding to various neurotransmitter receptors; 2) anti-inflammatory activity; 3) the effect on hemodynamics and vascular walls; 4) negative side effects and 5) pharmacokinetic parameters.Conclusion. The findings are consistent with the available experimental and clinical data and are indicative of promising clinical applications of etifoxine

ANTICIPATORY ADAPTATION AS A FACTOR OF FUTURE SUCCESSFUL WORK ACTIVITY OF A STUDENT

Статья посвящена рассмотрению перспективной (упреждающей) адаптации, ее механизмов и потенциальной возможности ее применения у студентов. Утверждается, что использование современных педагогических технологий, в том числе ситуационных, коммуникационных и деловых игр позволит включить механизмы перспективной адаптации и повысит успешность будущей трудовой деятельности студентаThe article is devoted to the consideration of perspective (proactive) adaptation, its mechanisms and the potential for its use by students. It is shown that modern pedagogical technologies, including situational, communication and business games, will enable the inclusion of mechanisms of perspective adaptation and increase the success of the student's labor activit

Psoriasis and metabolic syndrome: a review

Psoriasis is the most common chronic dermatosis and affects 1–2% of the population of developed countries. In Russia, psoriasis incidence rate has increased by 11% since 2011. Psoriasis is a chronic inflammatory and immune-mediated skin disease and it is often associated with metabolic syndrome and its components such as obesity, arterial hypertension, insulin resistance and dyslipidemia. The risk of developing metabolic syndrome in patients with psoriasis is 40% higher than in the general population. Psoriasis and metabolic syndrome share some pathogenic mechanisms such as chronic low-grade systemic inflammation and an increased level of pro-inflammatory cytokines. Systemic inflammation causes obesity, cardiovascular diseases, diabetes. These conditions increase the risk of mortality among patients. There is a link between the severity of psoriasis and metabolic syndrome and associated with severe rash, reduction of the remission and higher risk of psoriatic arthritis development. The carriers of the risk allele of FTO gene are associated with severe psoriasis, presence of psoriatic arthritis and obesity. The article presents the issues of epidemiology, etiology and pathogenesis of psoriasis and metabolic syndrome

Intestinal microbiotes in children: conditionally healthy and who underwent intestinal resection

The article is devoted to the cultural research of the intestinal microbiota in children of the first year of life. In children who underwent intestinal resection (n=47), in comparison with conditionally healthy (n=121), higher levels of facultative-anaerobic conditionally pathogenic flora, in particular the Enterobacteriaceae group (E. coli lactose-negative) and hemolytic, Klebsiella spp., Enterobacter spp., Citrobacter spp.) and group Morganellaceae (Proteus spp.), as well as Staphylococcus aureus, with a lower content of anaerobes.Статья посвящена культуральному исследованию кишечной микробиоты у детей первого года жизни. У детей, перенесших резекцию кишечника(n=47), по сравнению с условно здоровыми (n=121), более высокие уровни факультативно-анаэробной условно патогенной флоры, в частности группы Enterobacteriaceae (E. coli лактозонегативная и гемолитическая; Klebsiella spp., Enterobacter spp., Citrobacter spp.) и группы Morganellaceae (Proteus spp.), а также Staphylococcus aureus, при меньшем содержании анаэробов

Dietology elective course as an element of implementing a healthy way of life for prospective physicians

The article presents the results of mastering the dietology elective course by 6-year students of the faculty of general medicineВ статье представлен анализ результатов освоения программы электива по диетологии студентами 6 курса лечебно-профилактического факультета УГМ

Комбинированная оральная контрацепция и лечение новой коронавирусной инфекции (COVID-19): вопросы взаимодействия лекарственных средств

Combined oral contraception and treatment of new coronavirus infection (COVID-19): issues of drug interaction This article examines the interaction of combined oral contraceptives with drugs recommended in the treatment of new coronavirus infection (COVID-19) at the pharmacodynamic and pharmacokinetic levels, with an assessment of the effectiveness and safety of therapy for the female body.В данной статье рассматривается вопрос взаимодействия комбинированных оральных контрацептивов с ЛС, рекомендованными в лечении новой коронавирусной инфекции (COVID-19) на фармадинамическом и фармакокинетическом уровнях с оценкой степени эффективности и безопасности терапии для женского организма.

Air Pollen Monitoring in a Specific Region as a Part of the Pollinosis Prevention

Background: The prevalence and severity of allergic diseases, including pollinosis, are increasing worldwide. Hay fever develops due to the complex interaction of genes and manifests itself due to exogenous factors. The main environmental etiology of allergy is plant pollen. Continuous study and analysis of the air pollen spectrum constitute the basis of air monitoring and are important in developing preventive measures for allergic diseases.   Objective: To perform an air pollen monitoring in Kr snodar and to assess the treatment of patients with pollinosis in various cities and districts of the Krasnodar Region according to the Krasnodar Regional Allergy Center data.   Materials and methods: We retrospectively analyzed the patients seeking medical care due to allergy in the Krasnodar Region using the statistical data obtained in 2022 from the Krasnodar Regional Allergy Center. We assessed the effects of air pollen pollution according to the data of air pollen monitoring in Krasnodar during the main activity of herbaceous plants’ taxa (from April 1, 2022 to October 31, 2022). We used AeRobiology and Microsoft Excel 2010 tools for data processing and development of the main parameters of the pollen season.   Results: According to the Krasnodar Regional Allergy Center data, there were 37,212 people diagnosed with J45.0, J46 and 20,012 people diagnosed with J30.1-30.4 in 2022. We identified 8 allergenic taxa of herbaceous plants in the Krasnodar air. We found that the total seasonal pollen concentration increased by an average of 1.8 in 2022 compared to previous monitoring periods in 2018-2021.   Conclusions: Comparative assessment of the prevalence of pollinosis and the air pollen monitoring are important for effective medical care

Characteristic of the metabolic activity of the intestinal microbiota among the children of early age

In the article are presented data concerning study of the metabolic activity of the intestinal microbiota among the children aged from the neonatal period to three years old, who are conditionally healthy and belong to groups I and II of health classification. The dynamics of the content of short-chain fatty acids (FFA) in the feces have been analyzed, they are reflecting the activity of aerobic microbiota — acetic acid (C2); anaerobic microbiota — propionic (C3), butyric (C4) acid; the amount of acids (E); anaerobic index (AI) in newborn children, during the first year of life, in children of the second and third years of life. It is shown the differences in content of short-chain fatty acids in feces and their dynamics during the first three years of the child's life. It was found, that newborn children have higher activity indicators of obligate aerobic microflora, lower activity indicators of anaerobic processes and a higher level of total acid in feces. By the end of the third year of life, the metabolic activity of aerobic obligate flora decreases with a tendency to increase anaerobic processes, as evidenced by a decrease in the level of C2, an increase in C3, C4 and AI in the feces. The revealed features of the dynamics of the content of short-chain fatty acids in feces in young children reflect the process of formation of intestinal microbiota.В статье представлены данные об исследовании метаболической активности микробиоты кишечника у детей в возрасте от периода новорожденности до трех лет жизни, являющихся условно здоровыми и относящимися к I, II группам здоровья. Проанализирована динамика содержания короткоцепочечных жирных кислот (КЖК) в кале, отражающих активность аэробной микробиоты — уксусная кислота (С2); анаэробной микробиоты — пропионовая (С3), масляная (С4) кислоты; сумма кислот (Е); анаэробный индекс (АИ) у новорожденных детей, на протяжении первого года жизни, у детей второго и третьего года жизни. Показаны различия в содержании КЖК в кале и их динамика на протяжении первых трех лет жизни ребенка. Установлено, что новорожденные дети имеют более высокие показатели активности облигатной аэробной микрофлоры, более низкие показатели активности анаэробных процессов и более высокий уровень суммы кислот в кале. К концу третьего года жизни метаболическая активность аэробной облигатной флоры снижается при тенденции к увеличению анаэробных процессов, отражением чего является уменьшениеe уровня С2, нарастание С3, С4 и АИ в кале. Выявленные особенности динамики содержания КЖК в кале у детей раннего возраста являются отражением процесса становления микробиоты кишечник