The Initial-Value Problem of Spherically Symmetric Wyman Sector Nonsymmetric Gravitational Theory

We cast the four-dimensional field equations of the Nonsymmetric Gravitational Theory (NGT) into a form appropriate for numerical study. In doing so, we have restricted ourselves to spherically symmetric spacetimes, and we have kept only the Wyman sector of the theory. We investigate the well-posedness of the initial-value problem of NGT for a particular data set consisting of a pulse in the antisymmetric field on an asymptotically flat space background. We include some analytic results on the solvability of the initial-value problem which allow us to place limits on the regions of the parameter space where the initial-value problem is solvable. These results are confirmed by numerically solving the constraints.Comment: REVTeX 3.0 with epsf macros and AMS symbols, 18 pages, 9 figure

Abelian Anomalies in Nonlocal Regularization

Nonlocal regularization of QED is shown to possess an axial anomaly of the same form as other regularization schemes. The Noether current is explicitly constructed and the symmetries are shown to be violated, whereas the identities constructed when one properly considers the contribution from the path integral measure are respected. We also discuss the barrier to quantizing the fully gauged chiral invariant theory, and consequences.Comment: 21 pages, UTPT-93-0

The dynamical stability of the static real scalar field solutions to the Einstein-Klein-Gordon equations revisited

We re-examine the dynamical stability of the nakedly singular, static, spherical ly symmetric solutions of the Einstein-Klein Gordon system. We correct an earlier proof of the instability of these solutions, and demonstrate that there are solutions to the massive Klein-Gordon system that are perturbatively stable.Comment: 13 pages, uses Elsevier style files. To appear in Phys. Lett.

Evaluation of excess 234Th activity in sediments as an indicator of food quality for deep-sea deposit feeders

Deep-sea deposit feeders selectively ingest large volumes of sediment. Knowledge of the nature of this selectivity will help to elucidate the limiting nutritional requirements and geochemical impacts of these abundant animals. Shallow-water and theoretical studies suggest that deep-sea deposit feeders should select particles rich in protein, bacterial biomass, and/or chloropigment concentrations. Recent studies indicate that deep-sea megafaunal deposit feeders exhibit strong gut enrichment of excess (xs) 234Th activity, even though 234Thxs lacks nutritional value. To explore the significance of selective ingestion of 234Thxs activity, we evaluated the correlations between 234Thxs activity and three potential tracers of deposit feeder food quality: chlorophyll a (chl a), enzymatically hydrolyzable amino acids (EHAA), and adenosine triphosphate (ATP). Surface sediments from three quiescent bathyal basins off Southern California (San Nicolas, Santa Catalina, and San Clemente) were collected by a multiple corer and analyzed for 234Thxs activity, chl a, EHAA, ATP, and total organic carbon and nitrogen. 234Thxs activity was positively correlated with chl a and phaeopigment concentrations and negatively correlated with EHAA concentrations. Excess 234Th was not linearly correlated with concentrations of ATP, organic carbon, or total nitrogen. The results suggest that deep-sea deposit feeders select sediments with high 234Thxs activity because it is associated with recently settled phytodetrital material. There is no evidence that this 234Thxs-rich material has particularly high concentrations of labile amino acids or microbial biomass. Phytodetrital material may be an important source of some other limiting nutrient to deep-sea deposit feeders, e.g., polyunsaturated fatty acids, labile organic carbon and/or vitamins

The Dynamical Instability of Static, Spherically Symmetric Solutions in Nonsymmetric Gravitational Theories

We consider the dynamical stability of a class of static, spherically-symmetric solutions of the nonsymmetric gravitational theory. We numerically reproduce the Wyman solution and generate new solutions for the case where the theory has a nontrivial fundamental length scale \mu^{-1}. By considering spherically symmetric perturbations of these solutions we show that the Wyman solutions are generically unstable.Comment: 13 pages, uses amslatex, graphicx and subfigure package

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.

Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD

Sensory over-responsivity: parent report, direct assessment measures, and neural architecture

BACKGROUND: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. METHODS: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. RESULTS: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. CONCLUSIONS: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR

Effect of vitamin E (Tri E®) on antioxidant enzymes and DNA damage in rats following eight weeks exercise

<p>Abstract</p> <p>Background</p> <p>Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri E^®) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise.</p> <p>Methods</p> <p>Twenty four <it>Sprague-Dawley </it>rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri E^®, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri E^®. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage.</p> <p>Results</p> <p>SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group.</p> <p>Conclusions</p> <p>In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri E^®probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri E^®supplemented exercise group.</p

Hydrothermal vents and methane seeps: rethinking the sphere of influence

Although initially viewed as oases within a barren deep ocean, hydrothermal vents and methane seep chemosynthetic communities are now recognized to interact with surrounding ecosystems on the sea floor and in the water column, and to affect global geochemical cycles. The importance of understanding these interactions is growing as the potential rises for disturbance of the systems from oil and gas extraction, seabed mining and bottom trawling. Here we synthesize current knowledge of the nature, extent and time and space scales of vent and seep interactions with background systems. We document an expanded footprint beyond the site of local venting or seepage with respect to elemental cycling and energy flux, habitat use, trophic interactions, and connectivity. Heat and energy are released, global biogeochemical and elemental cycles are modified, and particulates are transported widely in plumes. Hard and biotic substrates produced at vents and seeps are used by "benthic background" fauna for attachment substrata, shelter, and access to food via grazing or through position in the current, while particulates and fluid fluxes modify planktonic microbial communities. Chemosynthetic production provides nutrition to a host of benthic and planktonic heterotrophic background species through multiple horizontal and vertical transfer pathways assisted by flow, gamete release, animal movements, and succession, but these pathways remain poorly known. Shared species, genera and families indicate that ecological and evolutionary connectivity exists among vents, seeps, organic falls and background communities in the deep sea: the genetic linkages with inactive vents and seeps and background assemblages however, are practically unstudied. The waning of venting or seepage activity generates major transitions in space and time that create links to surrounding ecosystems, often with identifiable ecotones or successional stages. The nature of all these interactions is dependent on water depth, as well as regional oceanography and biodiversity. Many ecosystem services are associated with the interactions and transitions between chemosynthetic and background ecosystems, for example carbon cycling and sequestration, fisheries production, and a host of non-market and cultural services. The quantification of the sphere of influence of vents and seeps could be beneficial to better management of deep-sea environments in the face of growing industrialization