New DA white dwarf evolutionary models and their pulsational properties

In this letter we investigate the pulsational properties of ZZ Ceti stars on the basis of new white dwarf evolutionary models calculated in a self-consistent way with the predictions of time dependent element diffusion and nuclear burning. In addition, full account is taken of the evolutionary stages prior to the white dwarf formation. Emphasis is placed on the trapping properties of such models. By means of adiabatic, non-radial pulsation calculations, we find, as a result of time dependent diffusion, a much weaker mode trapping effect, particularly for the high-period regime of the pulsation g-spectrum. This result is valid at least for models with massive hydrogen-rich envelopes. Thus, mode trapping would not be an effective mechanism to explain the fact that all the high periods expected from standard models of stratified white dwarfs are not observed in the ZZ Ceti stars.Comment: 3 pages, 5 figures, accepted for publication in Astronomy & Astrophysics Letter

The rate of period change in pulsating DB white dwarf stars

In this work, we present the theoretically expected rates of pulsation period change for V777 Her (DBV) variable stars. To this end we employ new evolutionary models representative of pulsating DB white dwarf stars computed in a self-consistent way with the predictions of time-dependent element diffusion. At the hot edge of the DB instability strip, the envelopes of the models are characterized by a diffusion-induced double-layered chemical structure. We compute the numerical values of rates of period change by solving the equations of linear, adiabatic, nonradial stellar oscillations. We examine the effects of varying the stellar mass, the mass of the helium envelope and the neutrino emission on the expected period changes. We present extensive tabulations of our results which could be useful for comparison with future detections of the rate of period change in pulsating DB white dwarfs.Comment: 13 pages, including 5 postscript figures and 9 tables. Accepted for publication in Astronomy and Astrophysic

The potential of the variable DA white dwarf G117-B15A as a tool for Fundamental Physics

White dwarfs are well studied objects. The relative simplicity of their physics allows to obtain very detailed models which can be ultimately compared with their observed properties. Among white dwarfs there is a specific class of stars, known as ZZ-Ceti objects, which have a hydrogen-rich envelope and show periodic variations in their light curves. G117-B15A belongs to this particular set of stars. The luminosity variations have been successfully explained as due to g-mode pulsations. G117-B15A has been recently claimed to be the most stable optical clock ever found, being the rate of change of its 215.2 s period very small: \dot{P}= (2.3 +- 1.4)x10^{-15} s s^-1, with a stability comparable to that of the most stable millisecond pulsars. The rate of change of the period is closely related to its cooling timescale, which can be accurately computed. In this paper we study the pulsational properties of G117-B15A and we use the observed rate of change of the period to impose constraints on the axion emissivity and, thus, to obtain a preliminary upper bound to the mass of the axion. This upper bound turns out to be 4cos^{2}{\beta} meV at the 95% confidence level. Although there are still several observational and theoretical uncertainties, we conclude that G117-B15A is a very promising stellar object to set up constraints on particle physics.Comment: 32 pages, 14 figures, accepted for publication in New Astronom

The double-layered chemical structure in DB white dwarfs

We study the structure and evolution of white dwarf stars with helium-rich atmospheres (DB) in a self-consistent way with the predictions of time-dependent element diffusion. Our treatment of diffusion includes gravitational settling and chemical and thermal diffusion. OPAL radiative opacities for arbitrary metallicity and carbon-and oxygen-rich compositions are employed. Emphasis is placed on the evolution of the diffusion-modeled double-layered chemical structure. This structure, which is characterized by a pure helium envelope atop an intermediate remnant shell rich in helium, carbon and oxygen, is expected for pulsating DB white dwarfs, assuming that they are descendants of hydrogen-deficient PG1159 post-AGB stars. We find that, depending on the stellar mass, if DB white dwarf progenitors are formed with a helium content smaller than \approx 10^-3 M_*, a single-layered configuration is expected to emerge during the DB pulsation instability strip. We also explore the consequences of diffusively evolving chemical stratifications on the adiabatic pulsational properties of our DB white dwarf models. In this context, we find that the evolving shape of the chemical profile translates into a distinct behaviour of the theoretical period distribution as compared with the case in which the shape of the profile is assumed to be fixed during the evolution across the instability strip. Finally, we extend the scope of the calculations to the domain of the helium-rich carbon-contaminated DQ white dwarfs. In particular, we speculate that DQ white dwarfs with low detected carbon abundances would not be descendants of the PG1159 stars.Comment: 10 Pages, including 11 Postscript figures. Accepted for publication in Astronomy and Astrophysic

Constants in Future Cities and Regions

The paper resumes some of the conversations the authors had in three years of research, based on the review of best participatory planning practices worldwide. The case projects are selected and discussed with the protagonists across four leading issues: Simulation, Scenario and Visioning, Government and Governance, and Scale. The case-oriented discussion is a peculiarity of the book , contributing to give shape to future cities or regions. The aim is to build a critical thinking on how urban planning, policy and design issues are faced differently or similarly throughout every cases studied. The book include the description of computer models and media, socio-political experiments and professional practices which help communicating the future effects of different design, policy and planning strategies and schemes with a wide range of aims: from information, through consultation, towards active participation. The cases have confirmed that simulation tools can impact on local government and can drive new forms of “glocal” governance, shaping and implementing future plans and projects at different scale and time span. The following paragraphs will point at some of the constant thoughts the authors had around the selection and editing of the book’s case studied and related issues

Time dependent diffusion in pulsating white dwarf stars: Asteroseismology of G117-B15A

We study the structural characteristic of the variable DA white dwarf G117B-15A by applying the methods of asteroseismology. For such a purpose, we construct white dwarf evolutionary models considering a detailed and up-to-date physical description as well as several processes responsible for the occurrence of element diffusion. We have considered several thickness for the outermost hydrogen layer, whereas for the inner helium-, carbon- and oxygen-rich layers we considered realistic profiles predicted by calculations of the white dwarf progenitor evolution. The evolution of each of the considered model sequences were followed down to very low effective temperature; in particular, from 12500K on we computed the dipolar, linear, adiabatic oscillations with low radial order. We find that asteroseismological results are not univocal regarding mode identification for the case of G117B-15A. However, our asteroseismological results are compatible with spectroscopical data only if the observed periods of 215.2, 271.0 and 304.4 s are due to dipolar modes with $k=2, 3, 4$ respectively. Our calculations indicate that the best fit to the observed period pattern of G117B-15A corresponds to a DA white dwarf structure with a stellar mass of 0.525 \msun, with a hydrogen mass fraction \lmh$\gtrsim$-3.83 at an effective temperature \teff$\approx$11800K.Comment: 8 pages, 8 figures, to be published in MNRA

Why small particle fixed dose triple therapy? An excursus from COPD pathology to pharmacological treatment evolution

Although bronchodilators are the cornerstone in chronic obstructive pulmonary disease (COPD) therapy, the treatment with a single-agent bronchodilator may not provide adequate symptoms control in COPD. The combination of drugs with different mechanisms of action may be more effective in inducing bronchodilation and preventing exacerbations, with a lower risk of side-effects in comparison with the increase of the dose of a single molecule. Several studies comparing the triple therapy with the association of long-acting ß2 agonist (LABA)/inhaled corticosteroid (ICS) or long-acting muscarinic antagonist (LAMA)/LABA reported improvement of lung function and quality of life. A significant reduction in moderate/severe exacerbations has been observed with a fixed triple combination of beclometasone dipropionate (BDP), formoterol fumarate (FF) and glycopyrronium (G) in a single inhaler. The TRILOGY, TRINITY and TRIBUTE studies have provided confirming evidence for a clinical benefit of triple therapy over ICS/LABA combination treatment, LAMA monotherapy and LABA/LAMA combination, with prevention of exacerbations being a key finding. A pooled post hoc analysis of the published clinical studies involving BDP/FF/G fixed combination demonstrated a reduction in fatal events in patients treated with ICS-containing medications, with a trend of statistical significance [hazard ratio = 0.72, 95% confidence interval (CI) 0.50–1.02, p = 0.066], that becomes significant if we consider reduction in fatal events for non-respiratory reasons (hazard ratio = 0.65, 95% CI 0.43–0.97, p = 0.037). In conclusion, a fixed combination of more drugs in a single inhaler can improve long-term adherence to the therapy, reducing the risk of exacerbations and hospital resources utilization. The twice a day administration may provide a better coverage of night, particularly in COPD patients who are highly symptomatic. The inhaled extrafine formulation that allows drug deposition in both large and small – peripheral – airways, is the value added

New evolutionary models for massive ZZ Ceti stars. II. The effects of crystallization on their pulsational properties

We present in this work new pulsational calculations for improved carbon-oxygen DA white dwarf models suitable for the study of massive ZZ Ceti stars. The background models employed in this study, presented in detail in a recent paper by Althaus et al. (2003), are the result of the complete evolution of massive white dwarf progenitors from the zero-age main sequence through the Asymptotic Giant Branch (AGB) and mass loss phases to the white dwarf regime. Abundance changes are accounted for by means of a full coupling between nuclear evolution and time-dependent mixing due to convection, salt fingers, and diffusive overshoot. In addition, time-dependent element diffusion for multicomponent gases has been considered during the white dwarf evolution. Crystallization and chemical rehomogenization due to phase separation upon crystallization in the core of our models have been fully considered. The effects of crystallization on the period spectrum of these massive white dwarf models are assessed by means of a detailed pulsational analysis. We find that the theoretical pulsation spectrum is strongly modified when crystallization is considered, in particular concerning the mode trapping properties of the equilibrium models. We also discuss at some length the implications of our study for BPM 37093, the most massive ZZ Ceti star presently known. We find that if BPM 37093 has a stellar mass of $\approx 1.00$ \msun its observed spectrum could bear the signature of overshoot episodes during the helium core burning.Comment: 15 Pages, including 17 Postscript figures. Accepted for publication in Astronomy and Astrophysic

Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: A pilot study

Background and aim: Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL). As histamine is the pivotal pathogenic mediator in SAR, antihistamines are the first-line option in the treatment. Cetirizine is a well-known effective antihistamine. This real-life pilot study aimed to investigate the effectiveness of a 4-week continu-ous cetirizine treatment in a group of Italian children with SAR. Methods: Total symptom score (TSS) and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline and the end of the treatment. Results: Cetirizine significantly improved QoL (in all domains) and symptom severity (p<0.001 for both). Conclusions: The present preliminary study showed that a 4-week cetirizine treatment was able to improve QoL significantly. Cetirizine treatment also significantly reduced symptom severity in Italian children with SAR and was safe