170 research outputs found
Phase transitions in diluted negative-weight percolation models
We investigate the geometric properties of loops on two-dimensional lattice
graphs, where edge weights are drawn from a distribution that allows for
positive and negative weights. We are interested in the appearance of spanning
loops of total negative weight. The resulting percolation problem is
fundamentally different from conventional percolation, as we have seen in a
previous study of this model for the undiluted case.
Here, we investigate how the percolation transition is affected by additional
dilution. We consider two types of dilution: either a certain fraction of edges
exhibit zero weight, or a fraction of edges is even absent. We study these
systems numerically using exact combinatorial optimization techniques based on
suitable transformations of the graphs and applying matching algorithms. We
perform a finite-size scaling analysis to obtain the phase diagram and
determine the critical properties of the phase boundary.
We find that the first type of dilution does not change the universality
class compared to the undiluted case whereas the second type of dilution leads
to a change of the universality class.Comment: 8 pages, 7 figure
Analysis of the loop length distribution for the negative weight percolation problem in dimensions d=2 through 6
We consider the negative weight percolation (NWP) problem on hypercubic
lattice graphs with fully periodic boundary conditions in all relevant
dimensions from d=2 to the upper critical dimension d=6. The problem exhibits
edge weights drawn from disorder distributions that allow for weights of either
sign. We are interested in in the full ensemble of loops with negative weight,
i.e. non-trivial (system spanning) loops as well as topologically trivial
("small") loops. The NWP phenomenon refers to the disorder driven proliferation
of system spanning loops of total negative weight. While previous studies where
focused on the latter loops, we here put under scrutiny the ensemble of small
loops. Our aim is to characterize -using this extensive and exhaustive
numerical study- the loop length distribution of the small loops right at and
below the critical point of the hypercubic setups by means of two independent
critical exponents. These can further be related to the results of previous
finite-size scaling analyses carried out for the system spanning loops. For the
numerical simulations we employed a mapping of the NWP model to a combinatorial
optimization problem that can be solved exactly by using sophisticated matching
algorithms. This allowed us to study here numerically exact very large systems
with high statistics.Comment: 7 pages, 4 figures, 2 tables, paper summary available at
http://www.papercore.org/Kajantie2000. arXiv admin note: substantial text
overlap with arXiv:1003.1591, arXiv:1005.5637, arXiv:1107.174
Supervised exercise with or without laser-guided feedback for people with non-specific chronic low back pain. A randomized controlled clinical trial
Background: Among the most effective therapeutic interventions in non-specific chronic low back pain (NSCLBP), clinical practice guidelines highlight exercise therapy and patient education; However, regarding the combined intervention of exercise and Pain Neuroscience Education (PNE), there is no consensus on the most effective form of exercise. Objetive: To find out what changes occurred after the application of two exercise modalities [Supervised Exercise (SE) and Laser-Guided Exercise (LGE)] and PNE on pain, pain pressure thresholds, disability, catastrophizing, kinesiophobia and lumbar proprioception in subjects with NSCLBP. Methods: Single-blind randomized clinical controlled trial. 60 subjects with NSCLBP. Both groups performed a a total of 16 therapeutic exercise sessions and 8 Pain Neuroscience Education sessions. With the Laser-Guided Exercise Therapy group performing laser-guided exercises. Results: A significant decrease was observed for pain intensity for both groups between baseline and post-intervention and the 3 month follow-up (p < 0.001). There was a significant between-group difference between baseline and post-intervention scores in terms of pain intensity and kinesiophobia in favour of the LGE group. Conclusion: Supervised exercise with or without laser feedback, when combined with PNE, reduces pain intensity, disability, pain catastrophizing, kinesiophobia and improves proprioception and PPTs in patients with NSCLBP. At a 3-month follow-up, the combination of LGE plus PNE is most effective for reducing pain intensity
Nonlinear Dynamics of Parity-Even Tricritical Gravity in Three and Four Dimensions
Recently proposed "multicritical" higher-derivative gravities in Anti de
Sitter space carry logarithmic representations of the Anti de Sitter isometry
group. While generically non-unitary already at the quadratic, free-theory
level, in special cases these theories admit a unitary subspace. The simplest
example of such behavior is "tricritical" gravity. In this paper, we extend the
study of parity-even tricritical gravity in d = 3, 4 to the first nonlinear
order. We show that the would-be unitary subspace suffers from a linearization
instability and is absent in the full non-linear theory.Comment: 22 pages; v2: references added, published versio
Avelumab, an Anti-Programmed Death-Ligand 1 Antibody, In Patients With Refractory Metastatic Urothelial Carcinoma: Results From a Multicenter, Phase Ib Study
Purpose We assessed the safety and antitumor activity of avelumab, a fully human anti-programmed death-ligand 1 (PD-L1) IgG1 antibody, in patients with refractory metastatic urothelial carcinoma. Methods In this phase Ib, multicenter, expansion cohort, patients with urothelial carcinoma progressing after platinum-based chemotherapy and unselected for PD-L1 expression received avelumab 10 mg/kg intravenously every 2 weeks. The primary objectives were safety and tolerability. Secondary objectives included confirmed objective response rate (Response Evaluation Criteria in Solid Tumors [RECIST] version 1.1), progression-free survival, overall survival (OS), and PD-L1-associated clinical activity. PD-L1 positivity was defined as expression by immunohistochemistry on ≥ 5% of tumor cells. Results Forty-four patients were treated with avelumab and followed for a median of 16.5 months (interquartile range, 15.8 to 16.7 months). The data cutoff was March 19, 2016. The most frequent treatment-related adverse events of any grade were fatigue/asthenia (31.8%), infusion-related reaction (20.5%), and nausea (11.4%). Grades 3 to 4 treatment-related adverse events occurred in three patients (6.8%) and included asthenia, AST elevation, creatine phosphokinase elevation, and decreased appetite. The confirmed objective response rate by independent central review was 18.2% (95% CI, 8.2% to 32.7%; five complete responses and three partial responses). The median duration of response was not reached (95% CI, 12.1 weeks to not estimable), and responses were ongoing in six patients (75.0%), including four of five complete responses. Seven of eight responding patients had PD-L1-positive tumors. The median progression-free survival was 11.6 weeks (95% CI, 6.1 to 17.4 weeks); the median OS was 13.7 months (95% CI, 8.5 months to not estimable), with a 12-month OS rate of 54.3% (95% CI, 37.9% to 68.1%). Conclusion Avelumab was well tolerated and associated with durable responses and prolonged survival in patients with refractory metastatic UC
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