90 research outputs found
The influence of sonication on the thermal behavior of muscovite and biotite
The differences on the thermal behavior (DTA-TG) of mica samples measured
before and after sonication have been studied. Sonication treatment produces
important modifications in the thermal behavior of muscovite and biotite
samples. For muscovite, it produces a broadening and decrease in temperature of
the dehydroxylation and crystallization effects, reaching a steady stage after
40 h treatment time. For biotite, the original single peak profile for the
dehydroxylation of the untreated sample is converted into a two peaks profile
after sonication, the intensity of the low temperature peak increases with
sonication time, while the intensity of the high temperature peak decreases.
The modification of the thermal behavior for sonicated samples has been
correlated to the particle size distribution effect produced by the sonication
treatment. It has been also observed that the cup tip of the sonication
equipment contaminates the samples releasing titanium of its compositio
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Formin Homology 2 Domain Containing 3 (FHOD3) Is a Genetic Basis for Hypertrophic Cardiomyopathy
BACKGROUND: The genetic cause of hypertrophic cardiomyopathy remains unexplained in a substantial proportion of cases. Formin homology 2 domain containing 3 (FHOD3) may have a role in the pathogenesis of cardiac hypertrophy but has not been implicated in hypertrophic cardiomyopathy. OBJECTIVES: This study sought to investigate the relation between FHOD3 mutations and the development of hypertrophic cardiomyopathy. METHODS: FHOD3 was sequenced by massive parallel sequencing in 3,189 hypertrophic cardiomyopathy unrelated probands and 2,777 patients with no evidence of cardiomyopathy (disease control subjects). The authors evaluated protein-altering candidate variants in FHOD3 for cosegregation, clinical characteristics, and outcomes. RESULTS: The authors identified 94 candidate variants in 132 probands. The variants' frequencies were significantly higher in patients with hypertrophic cardiomyopathy (74 of 3,189 [2.32%]) than in disease control subjects (18 of 2,777 [0.65%]; p < 0.001) or in the gnomAD database (1,049 of 138,606 [0.76%]; p < 0.001). FHOD3 mutations cosegregated with hypertrophic cardiomyopathy in 17 families, with a combined logarithm of the odds score of 7.92, indicative of very strong segregation. One-half of the disease-causing variants were clustered in a small conserved coiled-coil domain (amino acids 622 to 655); odds ratio for hypertrophic cardiomyopathy was 21.8 versus disease control subjects (95% confidence interval: 1.3 to 37.9; p < 0.001) and 14.1 against gnomAD (95% confidence interval: 6.9 to 28.7; p < 0.001). Hypertrophic cardiomyopathy patients carrying (likely) pathogenic mutations in FHOD3 (n = 70) were diagnosed after age 30 years (mean 46.1 ± 18.7 years), and two-thirds (66%) were males. Of the patients, 82% had asymmetric septal hypertrophy (mean 18.8 ± 5 mm); left ventricular ejection fraction <50% was present in 14% and hypertrabeculation in 16%. Events were rare before age 30 years, with an annual cardiovascular death incidence of 1% during follow-up. CONCLUSIONS: FHOD3 is a novel disease gene in hypertrophic cardiomyopathy, accounting for approximately 1% to 2% of cases. The phenotype and the rate of cardiovascular events are similar to those reported in unselected cohorts. The FHOD3 gene should be routinely included in hypertrophic cardiomyopathy genetic testing panels
Aplikace novĂ© metody SCRT pro syntĂ©zu a zpracovĂĄnĂ nanostrukturnĂch materiĂĄlĆŻ
The sample controlled reaction temperature (SCRT) methods consists of a new procedure of performing heat treatmens in materials processing
The influence of ultrasound on the thermal behaviour of kaolinite
Abstract The present study examines the effect of sonication on the structure and on the thermal behaviour of a well ordered kaolinite. XRD data indicated that sonication produces an increase of the translation disorder of kaolinite layers as well as delamination and particle-size reduction along the b-axis. As a consequence of this particle-size reduction the surface area increases sharply with sonication time from 8.5 to 83 m 2 /g, after 20 h of treatment. When sonication time increases, the original dehydroxylation effect shifts to lower temperatures, is narrowing and decreases in intensity at the same time that the exothermic effect, previous to the mullite formation shifts to lower temperatures and notably broadened
Thermal behaviour of ground and unground acid leached vermiculite
Acid leaching of vermiculite is an interesting procedure to prepare high surface area porous silica. Thermal behaviour of unground and ground vermiculite leached with HCl solutions has been studied by TG, DTA, ETA and high temperature XRD. Important differences have been observed in the thermal behaviour of unground and ground vermiculite after the acid treatments. Thus, for the acid-treated unground vermiculite, dehydrated vermiculite, enstatite and cristobalite were formed during the heating, while for the acid-treated ground vermiculite only iron oxides and cristobalite phases were observed. Structural modifications due to acid treatment were responsible for changes in the transport properties determined by ETA for the vermiculite samples.The paper was prepared in the frame of the bilateral cooperation between CSIC, Spain, and Academy of Sciences of the Czech Republic. The authors are grateful to the ïŹnancial support of Junta de AndalucĂa (TEP-03002), the Spanish Interministerial Commission for Science and Technology (MAT 2008-06619/ MAT) and the Academy of Sciences of the Czech Republic (LC 523).Peer Reviewe
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