Analysis of educational-research works of students of the third course of the faculty of dentistry in the department of pharmacology and clinical pharmacology

third-year students' educational research works of the faculty of Dentistry contribute to the in-depth study of the discipline «Pharmacology», form the skill of working with foreign scientific literature, provide an opportunity to analyze domestic and foreign experiments on the subject of researchучебно-исследовательские работы студентов (УИРС) III курса стоматологического факультета способствуют углубленному изучению учебной дисциплины «Фармакология», формируют навык работы с зарубежной научной литературой, дают возможность анализировать отечественный и зарубежный опыты по тематике исследовани

Эффективность и безопасность эрибулина при различных подтипах рака молочной железы: данные из реальной клинической практики в России

The article presents a pooled experience of the use of eribulin in the real clinical practice of treatment of metastatic breast cancer in Russian oncological institutions. The effectiveness of the drug in monotherapy with HER2‑negative breast cancer was analyzed, groups of patients with most effective use of eribulin were identified depending on the localization of metastases, the most effective lines of therapy. The effectiveness of the drug in combination with trastuzumab in HER2‑positive breast cancer is described, as well as toxic reactions. В статье представлен обобщенный опыт применения эрибулина в реальной клинической практике онкологических учреждений РФ при метастатическом раке молочной железы. Проанализирована эффективность препарата в монотерапии при HER2-отрицательном раке молочных желез, выделены группы больных в зависимости от локализации метастазов, линии терапии, в которых препарат оказался максимально эффективным. Описана эффективность препарата в комбинации с трастузумабом при HER2-положительном раке молочной железы, а также токсические реакции. 

Prevalence of joint pain and swelling complaints among children of Bashkortostan Republic according to an epidemiological examination

Objective. To study prevalence of joint pain and swelling among children of Bashkortostan republic (BR). Material and methods. A questionnaire study was conducted in 2 cities and 4 country districts of BR. A questionnaire developed by the Institute of rheumatology of RAMS and adapted for children was used. 43907 children aged 0 to 17 years were included. Results. 5490 children and/or their parents (12,5%) reported joint pain, 754 children (1,7%) - swelling. In general pain and swelling were revealed in 5533 children (12,6%). Joint pain and swelling prevalence was higher in urban than in country population. Joint pain predominated in girls, swelling - in boys. Swelling and pain frequency increased with age. It reached maximum by adolescence (12-17 years) but differences in joint pain frequency between children aged 12 to 14 and 15 to 17 were not statistically significant. Conclusion. Joint complaints (pain and/or swelling) are quite frequent among children and adolescents (12,6%). At present the second phase of the study is being conducted: advanced clinical, laboratory and instrumental examination of children having joint symptoms