Abiotrofia cerebelar em um gato: relato de caso

RESUMO Um caso de abiotrofia cerebelar em um gato com 45 dias de idade foi diagnosticado no Laboratório de Patologia Animal, Hospital Veterinário da Universidade Federal de Campina Grande. O animal apresentava, havia 15 dias, apatia, anorexia, desidratação, ataxia, hipermetria, espasticidade dos membros torácicos e pélvicos, tremores de intenção, nistagmo, opistótono, déficit proprioceptivo e ausência de resposta de ameaça. Clinicamente, havia a suspeita de hipoplasia cerebelar, e, devido ao prognóstico desfavorável, o animal foi eutanasiado. Na necropsia, não foram observadas alterações macroscópicas. Microscopicamente, as lesões estavam restritas ao cerebelo e caracterizavam-se por alterações neurodegenerativas e necróticas, com desaparecimento segmentar dos neurônios de Purkinje. Nessas áreas, também se verificaram espaços em branco, denominado aspecto de cesto vazio, resultantes da perda dos neurônios de Purkinje, além de raros esferoides axonais e proliferação dos astrócitos de Bergmann. Em algumas áreas, a camada granular estava hipocelular e havia moderada gliose multifocal na camada molecular. O diagnóstico de abiotrofia cerebelar foi realizado com base nos dados epidemiológicos, clínicos e, principalmente, pelas alterações histopatológicas dos neurônios de Purkinje características da doença

Megaesophagus in sheep and goats. [Megaesôfago em ovinos e caprinos].

ABSTRACT:Megaesophagus is a rare disease in ruminants characterized by regurgitation of rumen contents. In this paperit was described cases of megaesophagus in two sheep and two goats on a farm in the state of Paraíba, Northeastern Brazil. Allanimals showed regurgitation of rumen contents and weight loss, with a clinical course of several months. At necropsy all animalspresented megaesophagus. Histological examination showed segmental muscle necrosis in the esophagus and skeletal muscles.Serum samples from one sheep and one goat were negative for the presence of blue tongue antibodies by ELISA, and whole bloodand muscle samples from one goat were negative for this virus by RT PCR. Epidemiological data and pathology suggested that thedisease could have been caused by some toxic plant, but known plants causing segmental muscle necrosis were not observed in theareas where the disease occurred

Intestinal intussusception secondary to enteritis caused by Pythium insidiosum in a bitch: case report

ABSTRACT We report a case of intestinal intussusception secondary to enteritis caused by Pythium insidiosum infection in a 1-year-old mixed breed bitch that died after a 30-day history of bloody diarrhea, anorexia, weight loss, listlessness, dehydration, and pale mucous membranes. Necropsy revealed two areas of intussusception, one jejunum-jejunal and one ileum-cecum-colic. The first intussusception showed slight congestion of the intestinal loop, which was resolved by manual traction, while the second intussusception exhibited thickening, irregular yellow spots, and transmural congestion. Histologically, the jejunum-jejunal segment had ischemic lesions secondary and ileum-cecum-colic intussusception there was also necrotizing, pyogranulomatous enteritis associated with negative images of intralesional fungal hyphae that were well visualized by silver impregnation. Immunohistochemistry identified the hyphae as Pythium insidiosum. The diagnosis was made based on the histological changes and confirmed by immunohistochemistry. We can conclude that enteritis by P. insidiosum in dogs can occasionally cause intestinal intussusception and result in acute death