Unusual Case of Necrotizing Fasciitis Caused by Vibrio cholerae O137▿

We report a case of necrotizing fasciitis caused by Vibrio cholerae O137 in an immunocompromised 49-year-old man. The infection was acquired following a minor traumatic injury and exposure to seawater during the summer of 2009 in Italy. Although highly immunocompromised, the patient survived. The strain was cytotoxic, invasive, and adhesive and contained a fragment of the El Tor-like hemolysin (El Tor hlyA) gene

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.

MOTIVATION: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional categories, and estimate the genetic correlation between different phenotypes. Because the method relies on summary level results data, LD score regression is computationally tractable even for very large sample sizes. However, publicly available GWAS summary-level data are typically stored in different databases and have different formats, making it difficult to apply LD score regression to estimate genetic correlations across many different traits simultaneously. RESULTS: In this manuscript, we describe LD Hub - a centralized database of summary-level GWAS results for 173 diseases/traits from different publicly available resources/consortia and a web interface that automates the LD score regression analysis pipeline. To demonstrate functionality and validate our software, we replicated previously reported LD score regression analyses of 49 traits/diseases using LD Hub; and estimated SNP heritability and the genetic correlation across the different phenotypes. We also present new results obtained by uploading a recent atopic dermatitis GWAS meta-analysis to examine the genetic correlation between the condition and other potentially related traits. In response to the growing availability of publicly accessible GWAS summary-level results data, our database and the accompanying web interface will ensure maximal uptake of the LD score regression methodology, provide a useful database for the public dissemination of GWAS results, and provide a method for easily screening hundreds of traits for overlapping genetic aetiologies. AVAILABILITY AND IMPLEMENTATION: The web interface and instructions for using LD Hub are available at http://ldsc.broadinstitute.org/ CONTACT: [email protected] SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online

Religion and Misconduct in “Angola” Prison: Conversion, Congregational Participation, Religiosity, and Self-Identities

Prior research tends to find an inverse relationship between inmates’ religion and misconduct in prison, but this relationship has lacked empirical explanation. We therefore propose the religion-misconduct relationship is mediated by inmates’ identity transformation on existential, cognitive, and emotional dimensions. To test the mediation, we conducted a survey of inmates at the Louisiana State Penitentiary (a.k.a. “Angola”). Controlling for inmates’ sociodemographic and criminal backgrounds, we estimated a latent-variable structural equation model of disciplinary convictions. Results showed that inmates’ religious conversion and, to a lesser extent, religiosity itself were positively related to existential and cognitive transformations as well as a “crystallization of discontent,” which were in turn associated with two types of emotional transformation in the expected direction. The crystallization of discontent and transformation in negative affect were related to disciplinary convictions as hypothesized, and their mediation of the effects of conversion and religiosity on misconduct were found to be significant