Measurements of vacuum magnetic birefringence using permanent dipole magnets: the PVLAS experiment

The PVLAS collaboration is presently assembling a new apparatus (at the INFN section of Ferrara, Italy) to detect vacuum magnetic birefringence (VMB). VMB is related to the structure of the QED vacuum and is predicted by the Euler-Heisenberg-Weisskopf effective Lagrangian. It can be detected by measuring the ellipticity acquired by a linearly polarised light beam propagating through a strong magnetic field. Using the very same optical technique it is also possible to search for hypothetical low-mass particles interacting with two photons, such as axion-like (ALP) or millicharged particles (MCP). Here we report results of a scaled-down test setup and describe the new PVLAS apparatus. This latter one is in construction and is based on a high-sensitivity ellipsometer with a high-finesse Fabry-Perot cavity ($>4\times 10^5$) and two 0.8 m long 2.5 T rotating permanent dipole magnets. Measurements with the test setup have improved by a factor 2 the previous upper bound on the parameter $A_e$, which determines the strength of the nonlinear terms in the QED Lagrangian: $A_e^{\rm (PVLAS)} < 3.3 \times 10^{-21}$ T$^{-2}$ 95% c.l. Furthermore, new laboratory limits have been put on the inverse coupling constant of ALPs to two photons and confirmation of previous limits on the fractional charge of millicharged particles is given

First results from the new PVLAS apparatus: a new limit on vacuum magnetic birefringence

Several groups are carrying out experiments to observe and measure vacuum magnetic birefringence, predicted by Quantum Electrodynamics (QED). We have started running the new PVLAS apparatus installed in Ferrara, Italy, and have measured a noise floor value for the unitary field magnetic birefringence of vacuum $\Delta n_u^{\rm (vac)}= (4\pm 20) \times 10^{-23}$ T$^{-2}$ (the error represents a 1$\sigma$ deviation). This measurement is compatible with zero and hence represents a new limit on vacuum magnetic birefringence deriving from non linear electrodynamics. This result reduces to a factor 50 the gap to be overcome to measure for the first time the value of $\Delta n_u^{\rm (vac,QED)}$ predicted by QED: $\Delta n_u^{\rm (vac,QED)}= 4\times 10^{-24}$ ~T$^{-2}$. These birefringence measurements also yield improved model-independent bounds on the coupling constant of axion-like particles to two photons, for masses greater than 1 meV, along with a factor two improvement of the fractional charge limit on millicharged particles (fermions and scalars), including neutrinos

New PVLAS model independent limit for the axion coupling to γγ\gamma\gamma for axion masses above 1meV

During 2014 the PVLAS experiment has started data taking with a new apparatus installed at the INFN Section of Ferrara, Italy. The main target of the experiment is the observation of magnetic birefringence of vacuum. According to QED, the ellipticity generated by the magnetic birefringence of vacuum in the experimental apparatus is expected to be $\psi^{\rm(QED)} \approx 5\times10^{-11}$. No ellipticity signal is present so far with a noise floor $\psi^{\rm(noise)} \approx 2.5\times10^{-9}$ after 210 hours of data taking. The resulting ellipticity limit provides the best model independent upper limit on the coupling of axions to $\gamma\gamma$ for axion masses above $10^{-3}$eV

Measurement of the Cotton Mouton effect of water vapour

In this paper we report on a measurement of the Cotton Mouton effect of water vapour. Measurement performed at room temperature ($T=301$ K) with a wavelength of 1064 nm gave the value $\Delta n_u = (6.67 \pm 0.45) \cdot 10^{-15}$ for the unit magnetic birefringence (1 T magnetic field and atmospheric pressure)

Food Coloring Agents and Plant Food Supplements Derived from Vitis vinifera: A New Source of Human Exposure to Ochratoxin A

Grape pomaces are increasingly being used as starting material in the industrial production of plant food supplements (PFS), food coloring, and tartrates, but they are at risk of ochratoxin A (OTA) contamination, a mycotoxin with nephrotoxic and carcinogenic effects. We analyzed 24 commercial PFS and 13 food coloring samples derived from Vitis vinifera, mainly pomaces, using a HPLC−FLD method for OTA determination. OTA was found in 75% of PFS samples and 69% of food coloring samples at levels of &lt;1.16−20.23 μg/kg and &lt;1.16−32.00 μg/kg, respectively. The four commercial leavening agents containing tartrates were found to be negative for OTA. All eight samples collected in two distilleries that use grape pomaces and wine lees to produce tartrates and other byproducts contained OTA at levels of &lt;1.16−240.93 μg/kg. The high incidence of OTA contamination in PFS and food coloring agents derived from V. vinifera suggests that maximum permitted level(s) should be established for this mycotoxin in these products

Performance evaluation of Border irrigation method for cotton field

Performance evaluation of Border irrigation method was carried out for cotton field in village Kirarkot, Sirsa (Haryana). Water application, storage and distribution efficiency were estimated using measurements of soil moisture (%), infiltration rate (cm/hr), water advance and recession time (minute) during different irrigation events. The advance time increased during the growing season due to increased infiltration rate and increased resistance to flow by the growing crops. The water application efficiency of cotton field was 100 per cent as average applied depth (8.26 cm for canal irrigation and 9.06 cm for tubewell irrigation) of irrigation was less than the average required depth (10.30 cm for canal irrigation and 10.98 cm for tubewell irrigation) throughout the field plots. The observed water storage efficiency in different cotton fields varied from 72.92 - 90.08 per cent indicating under irrigation. Water distribution efficiency of cotton fields (97.8 -99.2per cent) indicated a relatively high degree of uniformity of water application. Stratified soil profile (sandy loam: 0-30 cm and sandy clay loam: 30-120 cm) of the selected fields reduced the infiltration rate to relatively very low value after 10-15 minutes creating favourable condition for uniformity of water application under border irrigation

Electron drift velocity measurements in liquid krypton–methane mixtures

Abstract Electron drift velocities have been measured in liquid krypton, pure and mixed with methane at different concentrations (1–10% in volume) versus electric field strength, and a possible effect of methane on electron lifetime has been investigated. While no effect on lifetime could be detected, since lifetimes were in all cases longer than what measurable, a very large increase in drift velocity (up to a factor 6) has been measured

(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone

Matrix Metalloproteinases (MMPs) are a family of secreted and membrane-bound enzymes, of which 24 isoforms are known in humans. These enzymes degrade the proteins of the extracellular matrix and play a role of utmost importance in the physiological remodeling of all tissues. However, certain MMPs, such as MMP-2, -9, and -13, can be overexpressed in pathological states, including cancer and metastasis. Consequently, the development of MMP inhibitors (MMPIs) has been explored for a long time as a strategy to prevent and hinder metastatic growth, but the important side effects linked to promiscuous inhibition of MMPs prevented the clinical use of MMPIs. Therefore, several strategies were proposed to improve the therapeutic profile of this pharmaceutical class, including improved selectivity toward specific MMP isoforms and targeting of specific organs and tissues. Combining both approaches, we conducted the synthesis and preliminary biological evaluation of a series of (2-aminobenzothiazole)-methyl-1,1-bisphosphonic acids active as selective inhibitors of MMP-13 via in vitro and in silico studies, which could prove useful for the treatment of bone metastases thanks to the bone-targeting capabilities granted by the bisphosphonic acid group

The species identification problem in mirids (Hemiptera: Heteroptera) highlighted by DNA barcoding and species delimitation studies

Due to the difficulties associated with detecting and correctly identifying mirids, developing an accurate species identification approach is crucial, especially for potential harmful species. Accurate identification is often hampered by inadequate morphological key characters, invalid and/or outdated systematics, and biases in the molecular data available in public databases. This study aimed to verify whether molecular characterization (i.e. DNA barcoding) is able to identify mirid species of economic relevance and if species delimitation approaches are reliable tools for species discrimination. Cytochrome c oxydase 1 (cox1) data from public genetic databases were compared with new data obtained from mirids sampled in different Italian localities, including an old specimen from private collection, showing contrasting results. Based on the DNA barcoding approach, for the genus Orthops, all sequences were unambiguously assigned to the same species, while in Adelphocoris, Lygus and Trigonotylus there were over-descriptions and/or misidentifications of species. On the other hand, in Polymerus and Deraeocoris there was an underestimation of the taxonomic diversity. The present study highlighted an important methodological problem: DNA barcoding can be a good tool for pest identification and discrimination, but the taxonomic unreliability of public DNA databases can make this method useless or even misleading