OTFS vs. OFDM in the Presence of Sparsity: A Fair Comparison

Many recent works in the literature declare that Orthogonal Time-Frequency-Space (OTFS) modulation is a promising candidate technology for high mobility communication scenarios. However, a truly fair comparison with its direct concurrent and widely used Orthogonal Frequency-Division Multiplexing (OFDM) modulation has not yet been provided. In this paper, we present such a fair comparison between the two digital modulation formats in terms of achievable communication rate. In this context, we explicitly address the problem of channel estimation by considering, for each modulation, a pilot scheme and the associated channel estimation algorithm specifically adapted to sparse channels in the Doppler-delay domain, targeting the optimization of the pilot overhead to maximize the overall achievable rate. In our achievable rate analysis we consider also the presence of a guard interval or cyclic prefix. The results are supported by numerical simulations, for different time-frequency selective channels including multiple scattering components and under non-perfect channel state information resulting from the considered pilot schemes. This work does not claim to establish in a fully definitive way which is the best modulation format, since such choice depends on many other features which are outside the scope of this work (e.g., legacy, intellectual property, ease and know-how for implementation, and many other criteria). Nevertheless, we provide the foundations to properly compare multi-carrier communication systems in terms of their information theoretic achievable rate potential, within meaningful and sensible assumptions on the channel models and on the receiver complexity (both in terms of channel estimation and in terms of soft-output symbol detection)

Microcorrosion Casts in the Microcirculation of Skeletal Muscle

The authors review the contribution of microcorrosion cast studies towards clarifying the structure of skeletal muscle microcirculation. Former studies performed on naturally contracted muscles show the presence of a primary and a secondary arterial network and a capillary network. At the level of the capillary network pericyte imprints are present. Muscles characterized by different types of metabolism show different features of the capillary pattern. Other authors have affirmed that the extended muscle is characterized by long and straight capillaries, while the contracted one features clusters of vessels all around a muscle fiber. The authors have made the present observations in order to determine how the capillary pattern of muscles with different metabolism is modified by extension and shortening of the muscle belly. The capillary pattern observed appears very similar to that observed in former studies. The differences between the oxidative and the glycolytic muscle are evident in every condition of the muscle belly. These data confirm the theory that there is a permanent endogenous difference in microcirculation between oxidative and glycolytic muscle, determined by muscle fiber metabolism

A Three-Dimensional Study of the Morphology and Topography of Pericytes in the Microvascular Bed of Skeletal Muscle

Digested tissue specimens and corrosion casts of rat soleus and tibialis anterior muscles were employed for this Scanning Electron Microscopy (SEM) study. The shape, morphology, and position of pericytes were compared to corresponding imprints on the cast surfaces. Pericytes, observed in digested tissue specimens, showed a typical morphological pattern: a central body with two primary processes that run along the capillary in opposite directions. From these primary processes, secondary ones arise and often encircle the vessel almost completely. On the surface of corrosion casts, roundish imprints were found in the microvascular tree at the same level where digested tissue specimens showed the presence of pericyte bodies. Along and around the cast surface, shallow grooves reproduced the course of the primary and secondary processes. The peculiar tridimensional arrangement of pericytes at the level of capillary bifurcations underlines their role in red cell flow regulation. However, if the mechanical linkage of the pericytes to the endothelium and their contractability is taken into account, additional roles of these perivascular cells may be hypothesized

NetCausality: A time-delayed neural network tool for causality detection and analysis

The analysis of causality between systems is still an important research activity, which finds application in several fields of science. The software presented is a new tool for causality detection and analysis between time series. The proposed technique is based on time-delayed neural networks (TDNN). The tool is developed in MATLAB and it comprises three main functions. The first one returns the total causality between two or more systems of equations. The second tool is used to find the ‘‘time horizon’’, id est the time delay at which the influence between the systems occurs. The last function is a causality feature detection to determine the time intervals, in which the mutual coupling is sufficiently strong to have a real influence on the target

The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study

Glioblastoma (GBM) is the most common and aggressive tumor of the central nervous system. Unfortunately, patients affected by this disease have a very poor prognosis, due to high level of invasiveness and resistance to standard therapies. Although the molecular profile of GBM has been extensively investigated, the events responsible for its pathogenesis and progression remain largely unknown. Histone Deacetylases (HDAC) dependent epigenetic modifications and transforming growth factor (TGF)-β/Smad pathway seem to play an important role in GBM tumorigenesis, resistance to common therapies and poor clinical outcome. The aim of this study was to evaluate the involvement and the possible interaction between these two molecular cascades in the pathogenesis and prognosis of GBM. Immunohistochemistry (IHC) was performed on microdissected GBM samples, collected from 14 patients (6 men and 8 women) ranging in age from 43 to 74 years. The patients were previously divided, on the basis of their overall survival (OS), into two groups: short and long OS. Patients with poor prognosis showed hyperexpression of HDAC4 and HDAC6, an activation of the TGF-β/Smad pathway, with high levels of IL-13, Smad2, PDGF and MMP3 expression, compared to the long survivors. The short OS group exhibits a decrease in Smad 7 expression and also low levels of p21 immunostaining, which represents a common target of the two pathways. The IHC data was confirmed by quantitative analysis and Immunoblotting. Our preliminary results suggest that both HDAC4 and HDAC6 together with the TGF-β/Smad pathway may be involved in progression of GBM and this cross talking could be a useful prognostic marker in this deadly disease

Acoustic attenuation rate in the Fermi-Bose model with a finite-range fermion-fermion interaction

We study the acoustic attenuation rate in the Fermi-Bose model describing a mixtures of bosonic and fermionic atom gases. We demonstrate the dramatic change of the acoustic attenuation rate as the fermionic component is evolved through the BEC-BCS crossover, in the context of a mean-field model applied to a finite-range fermion-fermion interaction at zero temperature, such as discussed previously by M.M. Parish et al. [Phys. Rev. B 71, 064513 (2005)] and B. Mihaila et al. [Phys. Rev. Lett. 95, 090402 (2005)]. The shape of the acoustic attenuation rate as a function of the boson energy represents a signature for superfluidity in the fermionic component