371 research outputs found

    Normal families and fixed points of iterates

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    Let F be a family of holomorphic functions and let K be a constant less than 4. Suppose that for all f in F the second iterate of f does not have fixed points for which the modulus of the multiplier is greater than K. We show that then F is normal. This is deduced from a result about the multipliers of iterated polynomials.Comment: 5 page

    Lyapunov exponents, bifurcation currents and laminations in bifurcation loci

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    Bifurcation loci in the moduli space of degree dd rational maps are shaped by the hypersurfaces defined by the existence of a cycle of period nn and multiplier 0 or eiθe^{i\theta}. Using potential-theoretic arguments, we establish two equidistribution properties for these hypersurfaces with respect to the bifurcation current. To this purpose we first establish approximation formulas for the Lyapunov function. In degree d=2d=2, this allows us to build holomorphic motions and show that the bifurcation locus has a lamination structure in the regions where an attracting basin of fixed period exists

    Characteristic functional equations of polynomials and the morera-carleman theorem

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    Several characteristic functional equations satisfied by classes of polynomials of bounded degree are examined in connection with certain generalizations of the Morera-Carleman Theorem. Certain functional equations which have nonanalytic polynomial solutions are also considered.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43923/1/10_2005_Article_BF02188016.pd

    Random Matrices in 2D, Laplacian Growth and Operator Theory

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    Since it was first applied to the study of nuclear interactions by Wigner and Dyson, almost 60 years ago, Random Matrix Theory (RMT) has developed into a field of its own within applied mathematics, and is now essential to many parts of theoretical physics, from condensed matter to high energy. The fundamental results obtained so far rely mostly on the theory of random matrices in one dimension (the dimensionality of the spectrum, or equilibrium probability density). In the last few years, this theory has been extended to the case where the spectrum is two-dimensional, or even fractal, with dimensions between 1 and 2. In this article, we review these recent developments and indicate some physical problems where the theory can be applied.Comment: 88 pages, 8 figure

    Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism

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    Malignant pleural mesothelioma (MPM) is an aggressive human cancer and miRNAs can play a key-role for this disease. In order to broaden the knowledge in this field, the miRNA expression was investigated in a large series of MPM to discover new pathways helpful in diagnosis, prognosis and therapy. We employed nanoString nCounter system for miRNA profiling on 105 MPM samples and 10 healthy pleura. The analysis was followed by the validation of the most significantly deregulated miRNAs by RT-qPCR in an independent sample set. We identified 63 miRNAs deregulated in a statistically significant way. MiR-185, miR-197, and miR-299 were confirmed differentially expressed, after validation study. In addition, the results of the microarray analysis corroborated previous findings concerning miR-15b-5p, miR-126-3p, and miR-145-5p. Kaplan-Meier curves were used to explore the association between miRNA expression and overall survival (OS) and identified a 2-miRNA prognostic signature (Let-7c-5p and miR-151a-5p) related to hypoxia and energy metabolism respectively. In silico analyses with DIANA-microT-CDS highlighted 5 putative targets in common between two miRNAs. With the present work we showed that the pattern of miRNAs expression is highly deregulated in MPM and that a 2-miRNA signature can be a new useful tool for prognosis in MPM
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