2,189 research outputs found
Anisotropic sub-Doppler laser cooling in dysprosium magneto-optical traps
Magneto-optical traps (MOTs) of Er and Dy have recently been shown to exhibit
population-wide sub-Doppler cooling due to their near degeneracy of excited and
ground state Lande g factors. We discuss here an additional, unusual intra-MOT
sub-Doppler cooling mechanism that appears when the total Dy MOT cooling laser
intensity and magnetic quadrupole gradient increase beyond critical values.
Specifically, anisotropically sub-Doppler-cooled cores appear, and their
orientation with respect to the quadrupole axis flips at a critical ratio of
the MOT laser intensity along the quadrupole axis versus that in the plane of
symmetry. This phenomenon can be traced to a loss of the velocity-selective
resonance at zero velocity in the cooling force along directions in which the
atomic polarization is oriented by the quadrupole field. We present data
characterizing this anisotropic laser cooling phenomenon and discuss a
qualitative model for its origin based on the extraordinarily large Dy magnetic
moment and Dy's near degenerate g factors.Comment: 4 pages, 5 figure
Spectroscopy of a narrow-line laser cooling transition in atomic dysprosium
The laser cooling and trapping of ultracold neutral dysprosium has been
recently demonstrated using the broad, open 421-nm cycling transition.
Narrow-line magneto-optical trapping of Dy on longer wavelength transitions
would enable the preparation of ultracold Dy samples suitable for loading
optical dipole traps and subsequent evaporative cooling. We have identified the
closed 741-nm cycling transition as a candidate for the narrow-line cooling of
Dy. We present experimental data on the isotope shifts, the hyperfine constants
A and B, and the decay rate of the 741-nm transition. In addition, we report a
measurement of the 421-nm transition's linewidth, which agrees with previous
measurements. We summarize the laser cooling characteristics of these
transitions as well as other narrow cycling transitions that may prove useful
for cooling Dy.Comment: 6+ pages, 5 figures, 5 table
Anisotropic sub-Doppler laser cooling in dysprosium magneto-optical traps
Magneto-optical traps (MOTs) of Er and Dy have recently been shown to exhibit populationwide sub-Doppler cooling due to their near degeneracy of excited-and ground-state Landé g factors. We discuss here an additional, unusual intra-MOT sub-Doppler cooling mechanism that appears when the total Dy MOT cooling laser intensity and magnetic quadrupole gradient increase beyond critical values. Specifically, anisotropically sub-Dopplercooled cores appear, and their orientation with respect to the quadrupole axis flips at a critical ratio of the MOT laser intensity along the quadrupole axis versus that in the plane of symmetry. This phenomenon can be traced to a loss of the velocity-selective resonance at zero velocity in the cooling force along directions in which the atomic polarization is oriented by the quadrupole field. We present data characterizing this anisotropic laser cooling phenomenon and discuss a qualitative model for its origin based on the extraordinarily large Dy magnetic moment and Dy's near degenerate g factors
CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target. However the success of the therapeutic targeting of CXCR2 is threatened by our relative lack of knowledge of its precise in vivo mode of action. Here we demonstrate that CXCR2-deficient mice display a counterintuitive transient exaggerated inflammatory response to cutaneous and peritoneal inflammatory stimuli. In both situations, this is associated with reduced expression of cytokines associated with the resolution of the inflammatory response and an increase in macrophage accumulation at inflamed sites. Analysis using neutrophil depletion strategies indicates that this is a consequence of impaired recruitment of a non-neutrophilic CXCR2 positive leukocyte population. We suggest that these cells may be myeloid derived suppressor cells. Our data therefore reveal novel and previously unanticipated roles for CXCR2 in the orchestration of the inflammatory response
The falling chain of Hopkins, Tait, Steele and Cayley
A uniform, flexible and frictionless chain falling link by link from a heap
by the edge of a table falls with an acceleration if the motion is
nonconservative, but if the motion is conservative, being the
acceleration due to gravity. Unable to construct such a falling chain, we use
instead higher-dimensional versions of it. A home camcorder is used to measure
the fall of a three-dimensional version called an -slider. After
frictional effects are corrected for, its vertical falling acceleration is
found to be . This result agrees with the theoretical
value of for an ideal energy-conserving -slider.Comment: 17 pages, 5 figure
The J-triplet Cooper pairing with magnetic dipolar interactions
Recently, cold atomic Fermi gases with the large magnetic dipolar interaction
have been laser cooled down to quantum degeneracy. Different from
electric-dipoles which are classic vectors, atomic magnetic dipoles are
quantum-mechanical matrix operators proportional to the hyperfine-spin of
atoms, thus provide rich opportunities to investigate exotic many-body physics.
Furthermore, unlike anisotropic electric dipolar gases, unpolarized magnetic
dipolar systems are isotropic under simultaneous spin-orbit rotation. These
features give rise to a robust mechanism for a novel pairing symmetry: orbital
p-wave (L=1) spin triplet (S=1) pairing with total angular momentum of the
Cooper pair J=1. This pairing is markedly different from both the He-B
phase in which J=0 and the He- phase in which is not conserved. It
is also different from the p-wave pairing in the single-component electric
dipolar systems in which the spin degree of freedom is frozen
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death
Intestinal epithelial cell (IEC) death is a common feature of inflammatory bowel disease (IBD) that triggers inflammation by compromising barrier integrity. In many patients with IBD, epithelial damage and inflammation are TNF-dependent. Elevated TNF production in IBD is accompanied by increased expression of the TNFAIP3 gene, which encodes A20, a negative feedback regulator of NF-ÎşB. A20 in intestinal epithelium from patients with IBD coincided with the presence of cleaved caspase-3, and A20 transgenic (Tg) mice, in which A20 is expressed from an IEC-specific promoter, were highly susceptible to TNF-induced IEC death, intestinal damage, and shock. A20-expressing intestinal organoids were also susceptible to TNF-induced death, demonstrating that enhanced TNF-induced apoptosis was a cell-autonomous property of A20. This effect was dependent on Receptor Interacting Protein Kinase 1 (RIPK1) activity, and A20 was found to associate with the Ripoptosome complex, potentiating its ability to activate caspase-8. A20-potentiated RIPK1-dependent apoptosis did not require the A20 deubiquitinase (DUB) domain and zinc finger 4 (ZnF4), which mediate NF-ÎşB inhibition in fibroblasts, but was strictly dependent on ZnF7 and A20 dimerization. We suggest that A20 dimers bind linear ubiquitin to stabilize the Ripoptosome and potentiate its apoptosis-inducing activity
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