15 research outputs found
Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China
Studies investigating possible associations between cytochrome P4501B1 (CYP1B1) polymorphisms and breast cancer risk have been inconsistent. We set out to ascertain whether there might be an association between polymorphisms in exon 2 (codon 119, G→T) and exon 3 (codon 432, G→C) of CYP1B1 and breast cancer in a Chinese Han population in the rural region of Ningxia. Using an allele-specific polymerase chain reaction method and direct DNA sequencing, the presence or absence of the two CYP1B1 polymorphisms was investigated. Genotype and allele frequencies were analyzed in breast cancer cases (n = 152) and healthy age-matched controls (n = 156). The odds ratio (OR) of 119G→T or 432G→C in breast cancer cases and controls was 3.3 (95% CI: 1.28 to 8.28) and 2.8 (95% CI: 1.04 to 7.51), respectively. In addition, the OR for people with both polymorphisms (119T and 432C) was 4.69 (95% CI: 1.97 to 11.19). Our results suggest that certain polymorphisms in the CYP1B1 gene might increase risk for breast cancer among Han Chinese, perhaps because they influence the efficiency of CYP1B1 bio-transformation of oestrogens or pro-carcinogens into DNA-reactive electrophiles that may act as cancer-initiating agents
The relationship between snoring and left ventricular hypertrophy of China: a cross-sectional study
Association of serum calcium and heart failure with preserved ejection fraction in patients with type 2 diabetes
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Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation
Synthetic
diblock copolypeptides were designed to incorporate oppositely
charged ionic segments that form β-sheet-structured hydrogel
assemblies via polyion complexation when mixed in aqueous media. The
observed chain conformation directed assembly was found to be required
for efficient hydrogel formation and provided distinct and useful
properties to these hydrogels, including self-healing after deformation,
microporous architecture, and stability against dilution in aqueous
media. While many promising self-assembled materials have been prepared
using disordered or liquid coacervate polyion complex (PIC) assemblies,
the use of ordered chain conformations in PIC assemblies to direct
formation of new supramolecular morphologies is unprecedented. The
promising attributes and unique features of the β-sheet-structured
PIC hydrogels described here highlight the potential of harnessing
conformational order derived from PIC assembly to create new supramolecular
materials