Proposed Hybrid Power System for Short Route Ferries

A fractional fuel consumption saving as well as pollution cuts will be a thinking pattern or a key concern in modern ship designs. Recent advances in technology for solar cells and photovoltaic (PV) modules have resulted in solar power being a cost-effective fuel reduction alternative for this objective. This paper is intended to provide a hybrid solar diesel power system for short-run ferries. This work proposes and emphasizes the energy efficiency, cost efficiency and minimal environmental impact of hybrid-powered ferries with solar diesel. The proposed system has been studied on the example of passenger-car ferry connecting the two banks of the Suez Canal at Port Said city - Egypt. Economic and environmental analyses have been conducted to determine and measure the advantages of the proposed system. The results show an economically viable and environmentally sustainable system if it were treated as a long-term investment. Compared to the equivalent diesel generator system, this system reduces exhaust emissions by about 375 tonnes per year. The fuel cost savings achieved are also significant

Attenuation of ferroptosis as a potential therapeutic target for neuropsychiatric manifestations of post-COVID syndrome

Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), is associated with the persistence of pre-existing or the emergence of new neurological and psychiatric manifestations as a part of a multi-system affection known collectively as “post-COVID syndrome.” Cognitive decline is the most prominent feature among these manifestations. The underlying neurobiological mechanisms remain under intense investigation. Ferroptosis is a form of cell death that results from the excessive accumulation of intracellular reactive iron, which mediates lipid peroxidation. The accumulation of lipid-based reactive oxygen species (ROS) and the impairment of glutathione peroxidase 4 (GPX4) activity trigger ferroptosis. The COVID-19-associated cytokine storm enhances the levels of circulating pro-inflammatory cytokines and causes immune-cell hyper-activation that is tightly linked to iron dysregulation. Severe COVID-19 presents with iron overload as one of the main features of its pathogenesis. Iron overload promotes a state of inflammation and immune dysfunction. This is well demonstrated by the strong association between COVID-19 severity and high levels of ferritin, which is a well-known inflammatory and iron overload biomarker. The dysregulation of iron, the high levels of lipid peroxidation biomarkers, and the inactivation of GPX4 in COVID-19 patients make a strong case for ferroptosis as a potential mechanism behind post-COVID neuropsychiatric deficits. Therefore, here we review the characteristics of iron and the attenuation of ferroptosis as a potential therapeutic target for neuropsychiatric post-COVID syndrome

Sex difference in the association between blood alcohol concentration and serum ferritin

IntroductionThe sex difference in alcohol use disorder (AUD) is ingrained in distinctive neurobiological responses between men and women, which necessitates further investigation for a more tailored management.MethodsMinding the findings of iron dysregulation in AUD and the sex difference in iron homeostasis in multiple physiological and pathological settings, we examined the sex difference in the association between serum ferritin and blood alcohol concentration (BAC) in intoxicated males (n = 125) and females (n = 59). We included patients with both serum ferritin tested of any value and a BAC above the level of detection during the same hospital admission period. We investigated sex difference in the relationship between BAC, serum ferritin and liver enzymes in intoxicated critically ill and noncritically ill patients.ResultsWe found a negative association between serum ferritin and BAC in critically ill, intoxicated females [R2 = 0.44, F(1,14) = 11.02, p = 0.005], with much attenuated serum ferritin in females compared to their male counterparts (194.5 ± 280.4 vs. 806.3 ± 3405.7 ng/L, p = 0.002). We found a positive association between serum ferritin and liver enzymes [alanine transaminase (ALT) and aspartate transferase (AST)] in critically ill intoxicated females [ALT: R2 = 0.48, F(1,10) = 9.1, p = 0.013; AST: R2 = 0.68, F(1,10) = 21.2, p = 0.001] and in noncritically ill intoxicated males [ALT: R2 = 0.1, F(1,83) = 9.4, p = 0.003; AST: R2 = 0.1, F(1,78) = 10.5, p = 0.002]. The effect of BAC on serum ferritin was not mediated by ALT [indirect effect: (B = 0.13, p = 0.1)]. We also found a significant effect of sex, anemia, intensive care unit (ICU) admission and mortality on serum ferritin.DiscussionOur results suggest that high BAC in intoxicated female patients is associated with attenuated serum ferritin levels, questioning the role of low serum ferritin in female vulnerability to alcohol

On integration of the Kowalevski gyrostat and the Clebsch problems

For the Kowalevski gyrostat change of variables similar to that of the Kowalevski top is done. We establish one to one correspondence between the Kowalevski gyrostat and the Clebsch system and demonstrate that Kowalevski variables for the gyrostat practically coincide with elliptic coordinates on sphere for the Clebsch case. Equivalence of considered integrable systems allows to construct two Lax matrices for the gyrostat using known rational and elliptic Lax matrices for the Clebsch model. Associated with these matrices solutions of the Clebsch system and, therefore, of the Kowalevski gyrostat problem are discussed. The Kotter solution of the Clebsch system in modern notation is presented in detail.Comment: LaTeX, 24 page

Atlas of two-dimensional irreversible conservative lagrangian mechanical systems with a second quadratic integral

This paper aims at the most comprehensive and systematic construction and tabulation of mechanical systems that admit a second invariant, quadratic in velocities, other than the Hamiltonian. The configuration space is in general a 2D Riemannian or pseudo-Riemannian manifold and the determination of its geometry is a part of the process of solution. Forces acting on the system include a part derived from a scalar potential and a part derived from a vector potential, associated with terms linear in velocities in the Lagrangian function of the system. The last cause time-irreversibility of the system. We construct 41 multi-parameter integrable systems of the type described in the title mostly on Riemannian manifolds. They are mostly new and cover all previously known systems as special cases, corresponding to special values of the parameters. Those include all known cases of motion of a particle in the plane and all known cases in the dynamics of rigid body. In the last field we introduce a new integrable case related to Steklov's case of motion of a body in a liquid. Several new cases of motion in the plane, on the sphere and on the pseudo-sphere or in the hyperbolic plane are found as special cases. Prospective applications in mathematics and physics are also pointed out.Comment: Paper to be published in "Journal of Mathematical Physics", Vol. 48, issue 7, July 200

Numerical aerodynamic simulation of the space shuttle ascent environment

After the STS 51-L accident, an extensive review of the Space Shuttle Orbiter's ascent aerodynamic loads uncovered several questionable areas that required further analysis. The insight gained by comparing the Shuttle ascent CFD numerical simulations, obtained by the NASA Ames Space Shuttle Flow Simulation Group, to the current IVBC-3 aerodynamic loads database was instrumental in resolving uncertainties on the Orbiter payload bay doors and fuselage. Initial confidence in the numerical simulations was gained by comparing them with the limited flight data that had been obtained during the Orbiter Flight Test (OFT) program. Current CFD results exist for Mach numbers 0.6, 0.9, 1.05, 1.55, 2.0, and 2.5. Since the pre STS-1 wind tunnel test program (IA-105) often yields considerable differences when compared to STS-5 flight data, the M(sub infinity) = 1.05 transonic case is the most investigated. The IA308 mated-vehicle hot gas plume wind tunnel test, recently completed at AEDC 16T (transonic) and Lewis (hypersonic), is also used to compare with the computation where applicable

Dynamic Time-Warping Correction for Shifts in Ultrahigh Resolving Power Ion Mobility Spectrometry and Structures for Lossless Ion Manipulations

Detection of arrival time shifts between ion mobility spectrometry (IMS) separations can limit achievable resolving power (Rp), particularly when multiple separations are summed or averaged, as commonly practiced in IMS. Such variations can be apparent in higher Rp measurements and are particularly evident in long path length traveling wave structures for lossless ion manipulations (SLIM) IMS due to their typically much longer separation times. Here, we explore data processing approaches employing single value alignment (SVA) and nonlinear dynamic time warping (DTW) to correct for variations between IMS separations, such as due to pressure fluctuations, to enable more effective spectrum summation for improving Rp and detection of low-intensity species. For multipass SLIM IMS separations, where narrow mobility range measurements have arrival times that can extend to several seconds, the SVA approach effectively corrected for such variations and significantly improved Rp for summed separations. However, SVA was much less effective for broad mobility range separations, such as obtained with multilevel SLIM IMS. Changes in ions’ arrival times were observed to be correlated with small pressure changes, with approximately 0.6% relative arrival time shifts being common, sufficient to result in a loss of Rp for summed separations. Comparison of the approaches showed that DTW alignment performed similarly to SVA when used over a narrow mobility range but was significantly better (providing narrower peaks and higher signal intensities) for wide mobility range data. We found that the DTW approach increased Rp by as much as 115% for measurements in which 50 IMS separations over 2 s were summed. We conclude that DTW is superior to SVA for ultra-high-resolution broad mobility range SLIM IMS separations and leads to a large improvement in effective Rp, correcting for ion arrival time shifts regardless of the cause, as well as improving the detectability of low-abundance species. Our tool is publicly available for use with universal ion mobility format (.UIMF) and text (.txt) files

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells

Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an appreciation of global intracellular trafficking associated with their cellular distribution has yet to be described. Despite the many aspects of the uptake mechanism of CNTs being studied, only a few studies have investigated internalization and fate of CNTs inside cells in detail. In the present study, intracellular localization and trafficking of RNA-wrapped, oxidized double-walled CNTs (oxDWNT–RNA) is presented. Fixed cells, previously exposed to oxDWNT–RNA, were subjected to immunocytochemical analysis using antibodies specific to proteins implicated in endocytosis; moreover cell compartment markers and pharmacological inhibitory conditions were also employed in this study. Our results revealed that an endocytic pathway is involved in the internalization of oxDWNT–RNA. The nanotubes were found in clathrin-coated vesicles, after which they appear to be sorted in early endosomes, followed by vesicular maturation, become located in lysosomes. Furthermore, we observed co-localization of oxDWNT–RNA with the small GTP-binding protein (Rab 11), involved in their recycling back to the plasma membrane via endosomes from the trans-golgi network

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Children with Neurofibromatosis type 1 (NF1) are increasingly recognized to have high prevalence of social difficulties and autism spectrum disorders (ASD). We demonstrated selective social learning deficit in mice with deletion of a single Nf1 gene (Nf1+/−), along with greater activation of mitogen activated protein kinase pathway in neurons from amygdala and frontal cortex, structures relevant to social behaviors. The Nf1+/− mice showed aberrant amygdala glutamate/GABA neurotransmissiondeficits in long-term potentiationand specific disruptions in expression of two proteins associated with glutamate and GABA neurotransmission: a disintegrin and metalloprotease domain 22 (ADAM22) and heat shock protein 70 (HSP70), respectively. All of these amygdala disruptions were normalized by co-deletion of p21 protein-activated kinase (Pak1) gene. We also rescued the social behavior deficits in Nf1+/− mice with pharmacological blockade of Pak1 directly in the amygdala. These findings provide novel insights and therapeutic targets for NF1 and ASD patients