Effects of structure formation on the expansion rate of the Universe: An estimate from numerical simulations

General relativistic corrections to the expansion rate of the Universe arise when the Einstein equations are averaged over a spatial volume in a locally inhomogeneous cosmology. It has been suggested that they may contribute to the observed cosmic acceleration. In this paper, we propose a new scheme that utilizes numerical simulations to make a realistic estimate of the magnitude of these corrections for general inhomogeneities in (3+1) spacetime. We then quantitatively calculate the volume averaged expansion rate using N-body large-scale structure simulations and compare it with the expansion rate in a standard FRW cosmology. We find that in the weak gravitational field limit, the converged corrections are slightly larger than the previous claimed 10^{-5} level, but not large enough nor even of the correct sign to drive the current cosmic acceleration. Nevertheless, the question of whether the cumulative effect can significantly change the expansion history of the Universe needs to be further investigated with strong-field relativity.Comment: 13 pages, 6 figures, improved version published in Phys. Rev.

Corpuls CPR Generates Higher Mean Arterial Pressure Than LUCAS II in a Pig Model of Cardiac Arrest

According to the European Resuscitation Council guidelines, the use of mechanical chest compression devices is a reasonable alternative in situations where manual chest compression is impractical or compromises provider safety. The aim of this study is to compare the performance of a recently developed chest compression device (Corpuls CPR) with an established system (LUCAS II) in a pig model. Methods. Pigs (n = 5/group) in provoked ventricular fibrillation were left untreated for 5 minutes, after which 15 min of cardiopulmonary resuscitation was performed with chest compressions. After 15 min, defibrillation was performed every 2 min if necessary, and up to 3 doses of adrenaline were given. If there was no return of spontaneous circulation after 25 min, the experiment was terminated. Coronary perfusion pressure, carotid blood flow, end-expiratory CO 2, regional oxygen saturation by near infrared spectroscopy, blood gas, and local organ perfusion with fluorescent labelled microspheres were measured at baseline and during resuscitation. Results. Animals treated with Corpuls CPR had significantly higher mean arterial pressures during resuscitation, along with a detectable trend of greater carotid blood flow and organ perfusion. Conclusion. Chest compressions with the Corpuls CPR device generated significantly higher mean arterial pressures than compressions performed with the LUCAS II device

Dataset for: One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

Data from manuscript, titled "One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer", published in Nature Biomedical Engineering. <div><br></div><div>For other inquiries, please contact Ashutosh Chilkoti ([email protected])</div