8,418 research outputs found
Test beam Characterizations of 3D Silicon Pixel detectors
3D silicon detectors are characterized by cylindrical electrodes
perpendicular to the surface and penetrating into the bulk material in contrast
to standard Si detectors with planar electrodes on its top and bottom. This
geometry renders them particularly interesting to be used in environments where
standard silicon detectors have limitations, such as for example the radiation
environment expected in an LHC upgrade. For the first time, several 3D sensors
were assembled as hybrid pixel detectors using the ATLAS-pixel front-end chip
and readout electronics. Devices with different electrode configurations have
been characterized in a 100 GeV pion beam at the CERN SPS. Here we report
results on unirradiated devices with three 3D electrodes per 50 x 400 um2 pixel
area. Full charge collection is obtained already with comparatively low bias
voltages around 10 V. Spatial resolution with binary readout is obtained as
expected from the cell dimensions. Efficiencies of 95.9% +- 0.1 % for tracks
parallel to the electrodes and of 99.9% +- 0.1 % at 15 degrees are measured.
The homogeneity of the efficiency over the pixel area and charge sharing are
characterized.Comment: 5 pages, 7 figure
Platinum(II) Complexes Bearing Triphenylphosphine and Chelating Oximes: Antiproliferative Effect and Biological Profile in Resistant Cells
Platinum(II) complexes of the type [Pt(Cl)(PPh3){(Îş2-N,O)-(1{C(R)=N(OH)-2(O)C6H4})}] with R=Me, H, (1 and 2) were synthesized and characterized. Single-crystal X-ray diffraction confirmed the proposed (SP4-3) configuration for 1. Study of the antiproliferative activity, performed on a panel of human tumor cell lines and on mesothelial cells, highlighted complex 2 as the more effective. In particular, it showed a remarkable cytotoxicity in ovarian carcinoma cells (A2780) and interestingly, a significant antiproliferative effect on cisplatin resistant cells (A2780cis). Investigation into the intracellular mechanism of action demonstrated that 2 had a lower ability to platinate DNA than did cisplatin, which was taken as reference, and a notably higher uptake in resistant cells. A significant accumulation in mitochondria, along with the ability to induce concentration-dependent mitochondrial membrane depolarization and intracellular reactive oxygen species production, allowed us to propose a mitochondrion-mediated pathway as responsible for the interesting cytotoxic profile of complex 2
New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells
Resistance to platinum-based anticancer drugs represents an important limit for their clinical effectiveness and one of the most important field of investigation in the context of platinum compounds. From our previous studies, PtII complexes containing the triphenylphosphino moiety have been emerging as promising agents, showing significant cytotoxicity to resistant ovarian carcinoma cells. Two brominated triphenylphosphino trans-platinum derivatives were prepared and evaluated on human tumor cell lines, sensitive and resistant to cisplatin. The new complexes exert a notable antiproliferative effect on resistant ovarian carcinoma cells, showing a remarkable intracellular accumulation and the ability to interact with different intracellular targets. The interaction with DNA, the collapse of mitochondrial transmembrane potential, and the impairment of intracellular redox state were demonstrated. Moreover, a selectivity towards the selenocysteine of thioredoxin reductase was observed. The mechanism of action is discussed with regard to the resistance phenomenon in ovarian carcinoma cells
2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B
A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (Ki ) values in the sub-micromolar range and a good selectivity index (Ki\u2009MAO-A /Ki\u2009MAO-B >50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4\u2009a) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity
Testbeam and Laboratory Characterization of CMS 3D Pixel Sensors
The pixel detector is the innermost tracking device in CMS, reconstructing
interaction vertices and charged particle trajectories. The sensors located in
the innermost layers of the pixel detector must be upgraded for the ten-fold
increase in luminosity expected with the High- Luminosity LHC (HL-LHC) phase.
As a possible replacement for planar sensors, 3D silicon technology is under
consideration due to its good performance after high radiation fluence. In this
paper, we report on pre- and post- irradiation measurements for CMS 3D pixel
sensors with different electrode configurations. The effects of irradiation on
electrical properties, charge collection efficiency, and position resolution of
3D sensors are discussed. Measurements of various test structures for
monitoring the fabrication process and studying the bulk and surface
properties, such as MOS capacitors, planar and gate-controlled diodes are also
presented.Comment: 14 page
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