Geochemistry of post-tectonic mafic intrusions in the Central Gneiss Terrane of southwestern Newfoundland

South of Grand Lake, mafic igneous complexes of proven or probable Silurian age intruded quartzofeldspathic gneisses that had been deformed and raised to granulite fades in mid-Ordovician time. The mafic igneous complexes consist of gabbroic units, which locally exhibit igneous layering and contain ultramafic cumulate pods, that grade to and are cut by finer-grained hornblende gabbro. Compositions more felsic than diorite exhibit intrusive to co-mingling relationships with more mafic rocks. Chemical data for possible liquid-derived rocks exhibit characteristics suggesting derivation from diverse mantle sources, followed by varying combinations of fractionation, contamination, mixing and metasomatism by hydrous fluids during ascent and emplacement. The post-tectonic emplacement of the plutons suggests stabilisation of die Central Gneiss Terrane by late Ordovician or Silurian time, when the adjacent terrane to the southeast (Meelpaeg Terrane) was still undergoing deformation and granitic plutonism. RÉSUMÉ Au sud de Grand Lake, des complexes ignés mafiques, dont l’âge est assurément ou probablement silurien, firent intrusion dans desgneiss quartzofeldspathiques qui avaient été déforrnés avaient atteint le faciès des granulites au milieude l’Ordovicien. Les complexes ignés mafiques sont constitues d'unités gabbroiques (montrant localement un aspect rubanné et contenant des lentilles de cumulate ultramaflques) passant graduellement à un gabbro à hornblende moins grenu qui les recoupe aussi. Les compositions plus felsiques que la diorite sont en relation d'intrusion ou de mélange avec les roches plus mafiques. Les données chimiques concernant des roches possiblement derives du liquide montrent des caractéres suggèrant une dérivation à partir de diverses sources mantelliques, suivie d'une combinaison variée de fractionnement, contamination, mélange et métasomatisme par des fluides aqueux durant l'ascension et l’emplacement. L'emplacement post-tectonique des plutons suggère une stabilisation de la lanière Central Gneiss Terrane avant l'Ordovicien tardif ou le Silurien, au moment ou la lanière adjacente au sud-est (la Lanière de Meelpaeg) subissait encore une déformation et un plutonisme granitique. [Traduit par le journal

Ion-ion proton transfer reactions of bio-ions involving noncovalent interactions: Holomyoglobin

Multiply protonated horse skeletal muscle holomyoglobin and apomyoglobin have been subjected to ion-ion proton transfer reactions with anions derived from perfluoro-1,3dimethylcyclohexane in a quadrupole ion trap operated with helium as a bath gas at 1 mtorr. Neither the apomyoglobin nor holomyoglobin ions show any sign of fragmentation associated with charge state reduction to the 1 + charge state. This is particularly noteworthy for the holomyoglobin ions, which retain the noncovalently bound heme group. For example, no sign of heme loss is associated with charge state reduction from the 9 + charge state of holomyoglobin to the 1 + charge state despite the eight consecutive highly exothermic proton transfer reactions required to bring about this charge change. This result is consistent with calculations that show the combination of long ion lifetime and the high ion-helium collision rate relative to the ion-ion collision rate makes fragmentation unlikely for high mass ions in the ion trap environment even for noncovalently bound complexes of moderate binding strength. The ion-ion proton transfer rates for holo- and apomyoglobin ions of the same charge state also were observed to be indistinguishable, which supports the expectation that ion-ion proton transfer rates are insensitive to ion structure and are determined primarily by the attractive Coulomb field

Age of high-grade gneisses south of Grand Lake, Newfoundland

Crystalline rocks of the Steel Mountain Subzone of the Humber Zone in southwest Newfoundland give an age for granulite-grade metamorphism of 1498+9/-8 Ma, similar to ages from the Long Range inlier and northwestern Cape Breton Island. Peralkaline leucogranite was emplaced at 608 ± 4 Ma. The emplacement of anorthosite-gabbro complexes and amphibolite-grade metamorphism took place between these dates. The southern part of the Dunnage Zone (Central Gneiss Subzone), in contact with the Steel Mountain Subzone at the Long Range Fault, lacks Precambrian crystalline rocks, but was intruded by charnockitic plutons and metamorphosed to granulite facies at 460 ±10 Ma. This subzone was exhumed before 435 Ma. In the Meelpaeg Subzone of the Gander Zone, which is in contact with the Central Gneiss Subzone along the Victoria River Fault, the oldest intrusive component of a granoblastic migmatitic gneiss was emplaced at 418 ± 4 Ma. These data demonstrate that both the Long Range and Victoria River faults form major tectonic boundaries. Subzones appear to have been thrust westward in Silurian or later time. RÉSUMÉ Les roches cristallines de la sous-zone du mont Steel, dans la zone de Humber du sud-ouest de Terre-Neuve, ont donné des âges de 1498+9/-8 Ma pour le métamorphisme de haul grade, similaires à ceux de la boutonnière de Long Range et du nord de l'ile-du-Cap-Breton. Un leucogranite peralcalin s'est mis en place à 608 ± 4 Ma. L'intrusion des complexes à anorthosite-gabbro et le métamorphisme au faciès amphibolite se sont produits entre ces deux évènements. La partie sud de la zone de Dunnage (sous-zone de gneiss centrale), en contact avec la sous-zone du mont Steel a la faille de Long Range, ne contient pas de roches cristallines précambriennes mais à 616 recouped par des plutons charnockitiques et à 616 métamorphisée au faciès granulite à 460 ± 10 Ma. Cette sous-zone a été exhumge avant 435 Ma. Dans la sous-zone Mulpaeg de la zone de Gander, qui est mise en contact avec la sous-zone de gneiss centrale par la faille de la rivière Victoria, la phase intrusive la plus ancienne d'un gneiss migmatitique et granoblastique s'est mise en place à 418 ± 4 Ma. Ces données démontrent que les failles de Long Range et de la rivière Victoria sont des frontières tectoniques majeures. Les sous-zones semblent avoir subi un chevauchement vers l'ouest au plus tard au Silurien. [Traduit par le journal

Why Do Employers (Fail to) Hire People with Disabilities? : A Systematic Review of Capabilities, Opportunities and Motivations.

Purpose To increase the number of people with disabilities in employment, we need to understand what influences employers’ hiring decisions. In this systematic review, we map out factors affecting employers’ hiring decisions about people with disabilities. Methods This study is a systematic review that applies the COM-B model to identify factors that contribute to employers (not) hiring people with disabilities. The COM-B model proposes that employers will perform hiring behavior (B) if they have the capability (C), opportunity (O) and motivation (M) to do so. We also investigate if factors have a negative, positive or no effect. We report in accordance with the PRISMA guidelines. Results In a review of 47 studies, we find 32 factors. Most of these factors are barriers. The most frequently mentioned barriers are employers’ (1) expectations that people with disabilities are unproductive, (2) expectations that people with disabilities cost a lot of money, and employers’ (3) lack of knowledge about disabilities. The most researched facilitators for employers to hire people with disabilities include (1) the motivation to help others, (2) working in a large organization, and (3) expecting a competitive advantage. The effect of factors can differ depending on contextual circumstances, including the type of organization, the type of disability and different policies. Conclusions We conclude that hiring decisions are influenced by an array of different barriers and facilitators. The effect of these factors can differ across organizations and disability types. Our study of factors affecting hiring can be used by scholars, policy makers, and organizations to create interventions to increase the hiring of people with disabilities

Automating Agential Reasoning: Proof-Calculi and Syntactic Decidability for STIT Logics

This work provides proof-search algorithms and automated counter-model extraction for a class of STIT logics. With this, we answer an open problem concerning syntactic decision procedures and cut-free calculi for STIT logics. A new class of cut-free complete labelled sequent calculi G3LdmL^m_n, for multi-agent STIT with at most n-many choices, is introduced. We refine the calculi G3LdmL^m_n through the use of propagation rules and demonstrate the admissibility of their structural rules, resulting in auxiliary calculi Ldm^m_nL. In the single-agent case, we show that the refined calculi Ldm^m_nL derive theorems within a restricted class of (forestlike) sequents, allowing us to provide proof-search algorithms that decide single-agent STIT logics. We prove that the proof-search algorithms are correct and terminate

Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation

Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features of autoimmune disease, we investigated the impact of hematopoietic Bim deficiency on plaque formation and parameters of plaque stability. Bim−/− or wild type bone marrow transplanted ldlr−/− mice were fed a Western type diet (WTD) for 5 or 10 weeks, after which they were immunophenotyped and atherosclerotic lesions were analyzed. Bim−/− transplanted mice displayed splenomegaly and overt lymphocytosis. CD4+ and CD8+ T cells were more activated (increased CD69 and CD71 expression, increased interferon gamma production). B cells were elevated by 147%, with a shift towards the pro-atherogenic IgG-producing B2 cell phenotype, resulting in a doubling of anti-oxLDL IgG1 antibody titers in serum of bim−/− mice. Bim−/− mice displayed massive intraplaque accumulation of Ig complexes and of lesional T cells, although this did not translate in changes in plaque size or stability features (apoptotic cell and macrophage content). The surprising lack in plaque phenotype despite the profound pro-atherogenic immune effects may be attributable to the sharp reduction of serum cholesterol levels in WTD fed bim−/− mice