319 research outputs found
Twisted mass fermions: neutral pion masses from disconnected contributions
Twisted mass fermions allow light quarks to be explored but with the
consequence that there are mass splittings, such as between the neutral and
charged pion. Using a direct calculation of the connected neutral pion
correlator and stochastic methods to evaluate the disconnected correlations, we
determine the neutral pion mass. We explore the dependence on lattice spacing
and quark mass in quenched QCD. For dynamical QCD, we determine the sign of the
splitting which is linked, via chiral PT, to the nature of the phase transition
at small quark mass.Comment: 6 pages, poster (hadron spectrum and quark masses) at Lattice
2005,Dublin, July 25-3
B-physics computations from Nf=2 tmQCD
We present an accurate lattice QCD computation of the b-quark mass, the B and
Bs decay constants, the B-mixing bag-parameters for the full four-fermion
operator basis, as well as estimates for \xi and f_{Bq}\sqrt{B_q} extrapolated
to the continuum limit and the physical pion mass. We have used Nf = 2
dynamical quark gauge configurations at four values of the lattice spacing
generated by ETMC. Extrapolation in the heavy quark mass from the charm to the
bottom quark region has been carried out using ratios of physical quantities
computed at nearby quark masses, having an exactly known infinite mass limit.Comment: 7 pages, 4 figures, presented at the 31st International Symposium on
Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, German
Comparison between overlap and twisted mass fermions towards the chiral limit
We compare overlap fermions, which are chirally invariant, and Wilson twisted
mass fermions in the approach to the chiral limit. Our quenched simulations
reveal that with both formulations of lattice fermions pion masses of O(250
MeV) can be reached in practical simulations. Our comparison is done at a fixed
lattice spacing a=0.123 fm. Several quantities are measured, such as hadron
masses and pseudoscalar decay constants.Comment: Lattice2004(chiral
A first look at maximally twisted mass lattice QCD calculations at the physical point
In this contribution, a first look at simulations using maximally twisted
mass Wilson fermions at the physical point is presented. A lattice action
including clover and twisted mass terms is presented and the Monte Carlo
histories of one run with two mass-degenerate flavours at a single lattice
spacing are shown. Measurements from the light and heavy-light pseudoscalar
sectors are compared to previous results and their phenomenological
values. Finally, the strategy for extending simulations to is
outlined.Comment: presented at the 31st International Symposium on Lattice Field Theory
(Lattice 2013), 29 July - 3 August 2013, Mainz, German
Lattice Spacing Dependence of the First Order Phase Transition for Dynamical Twisted Mass Fermions
Lattice QCD with Wilson fermions generically shows the phenomenon of a first
order phase transition. We study the phase structure of lattice QCD using
Wilson twisted mass fermions and the Wilson plaquette gauge action are used in
a range of beta values where such a first order phase transition is observed.
In particular, we investigate the dependence of the first order phase
transition on the value of the lattice spacing. Using only data in one phase
and neglecting possible problems arising from the phase transition we are able
to perform a first scaling test for physical quantities using this action.Comment: 15 pages, 7 figures, typo corrected, web-list of authors correcte
Twisted mass chiral perturbation theory for 2+1+1 quark flavours
We present results for the masses of pseudoscalar mesons in twisted mass
lattice QCD with a degenerate doublet of u and d quarks and a non-degenerate
doublet of s and c quarks in the framework of next-to-leading order chiral
perturbation theory, including lattice effects up to O(a^2). The masses depend
on the two twist angles for the light and heavy sectors. For maximal twist in
both sectors, O(a)-improvement is explicitly exhibited. The mixing of
flavour-neutral mesons is also discussed, and results in the literature for the
case of degenerate s and c quarks are corrected.Comment: LaTeX2e, 12 pages, corrected typo
Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis
<p>Abstract</p> <p>Background</p> <p>Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor, IL-17RA, which is expressed in many peripheral tissues; however, expression of IL-17RA in the central nervous system (CNS) and its role in CNS inflammation are not well understood.</p> <p>Methods</p> <p>EAE was induced in C57Bl/6 mice by immunization with myelin oligodendroglial glycoprotein. IL-17RA expression in the CNS was compared between control and EAE mice using RT-PCR, in situ hybridization, and immunohistochemistry. Cell-type specific expression was examined in isolated astrocytic and microglial cell cultures. Cytokine and chemokine production was measured in IL-17A treated cultures to evaluate the functional status of IL-17RA.</p> <p>Results</p> <p>Here we report increased IL-17RA expression in the CNS of mice with EAE, and constitutive expression of functional IL-17RA in mouse CNS tissue. Specifically, astrocytes and microglia express IL-17RA <it>in vitro</it>, and IL-17A treatment induces biological responses in these cells, including significant upregulation of MCP-1, MCP-5, MIP-2 and KC chemokine secretion. Exogenous IL-17A does not significantly alter the expression of IL-17RA in glial cells, suggesting that upregulation of chemokines by glial cells is due to IL-17A signaling through constitutively expressed IL-17RA.</p> <p>Conclusion</p> <p>IL-17RA expression is significantly increased in the CNS of mice with EAE compared to healthy mice, suggesting that IL-17RA signaling in glial cells can play an important role in autoimmune inflammation of the CNS and may be a potential pathway to target for therapeutic interventions.</p
The phase structure of lattice QCD with two flavours of Wilson quarks and renormalization group improved gluons
The effect of changing the lattice action for the gluon field on the recently
observed [1] first order phase transition near zero quark mass is investigated
by replacing the Wilson plaquette action by the DBW2 action. The lattice action
for quarks is unchanged: it is in both cases the original Wilson action. It
turns out that Wilson fermions with the DBW2 gauge action have a phase
structure where the minimal pion mass and the jump of the average plaquette are
decreased, when compared to Wilson fermions with Wilson plaquette action at
similar values of the lattice spacing. Taking the DBW2 gauge action is
advantageous also from the point of view of the computational costs of
numerical simulations.Comment: 34 pages, 3 tables, 14 figures; revised version to appear in EPJ
Non-perturbative Test of the Witten-Veneziano Formula from Lattice QCD
We compute both sides of the Witten-Veneziano formula using lattice
techniques. For the one side we perform dedicated quenched simulations and use
the spectral projector method to determine the topological susceptibility in
the pure Yang-Mills theory. The other side we determine in lattice QCD with
dynamical Wilson twisted mass fermions including for the first time
also the flavour singlet decay constant. The Witten-Veneziano formula
represents a leading order expression in the framework of chiral perturbation
theory and we also employ leading order chiral perturbation theory to relate
the flavor singlet decay constant to the relevant decay constant parameters in
the quark flavor basis and flavor non-singlet decay constants. After taking the
continuum and the SU chiral limits we compare both sides and find good
agreement within uncertainties.Comment: 30 pages, 7 figures, version accepted for publicatio
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