Fast Algorithms For Josephson Junction Arrays : Bus--bars and Defects

We critically review the fast algorithms for the numerical study of two--dimensional Josephson junction arrays and develop the analogy of such systems with electrostatics. We extend these procedures to arrays with bus--bars and defects in the form of missing bonds. The role of boundaries and of the guage choice in determing the Green's function of the system is clarified. The extension of the Green's function approach to other situations is also discussed.Comment: Uuencoded 1 Revtex file (11 Pages), 3 Figures : Postscript Uuencode

Transgenic Animals

This project describes the technology of inserting foreign DNA into the genomes of animals to create transgenic animals that benefit society. Transgenic animals have served as models for screening vaccines, producing drugs, or producing organs for patients awaiting transplants. The first chapter describes transgenic technology, while chapter-2 shows examples of how these animals are used. The third chapter introduces some of the ethical issues associated with this technology, while the fourth chapter describes the laws regulating the technology, and the pros and cons of animal patenting. The authors finally provide their own unique perspectives on the issues addressed in the chapters

iStent with Phacoemulsification versus Phacoemulsification Alone for Patients with Glaucoma and Cataract: A Meta-Analysis.

Minimally invasive glaucoma surgeries (MIGS) have attracted significant attention, as they have been reported to lower intra-ocular pressure (IOP) and have an excellent safety profile. The iStent is an example of a minimally invasive glaucoma device that has received particular attention due to its early and wide spread utilization. There is a growing body of evidence supporting its use at the time of phacoemulsification to help lower IOP. However, it is still not clear how much of the IOP lowering effect can be attributed to the iStent, the crystalline lens extraction or both when inserted concurrently at the time of phacoemulsification. This has been an important issue in understanding its potential role in the glaucoma management paradigm.To conduct a systematic review and meta-analysis comparing the IOP lowering effect of iStent insertion at the time of phacoemulsification versus phacoemulsification alone for patients with glaucoma and cataracts.A systematic review was conducted utilizing various databases. Studies examining the IOP lowering effect of iStent insertion in combination with phacoemulsification, as well as studies examining the IOP lowering effect of phacoemulsification alone were included. Thirty-seven studies, reporting on 2495 patients, met the inclusion criteria. The percentage reduction in IOP (IOPR%) and mean reduction in topical glaucoma medications after surgery were determined. The standardized mean difference (SMD) was computed as a measure of the treatment effect for continuous outcomes taking into account heterogeneity. Fixed-effect and random-effect models were applied.A 4% IOP reduction (IOPR%) from baseline occurred following phacoemulsification as a solo procedure compared to 9% following an iStent implant with phacoemulsification, and 27% following 2 iStents implants with phacoemulsification. Compared with cataract extraction alone, iStent with phacoemulsification resulted in significant reduction in the post-operative IOP (IOPR%) (SMD = -0.46, 95% CI: [-0.87, -0.06]). A weighted mean reduction in the number of glaucoma medications per patient was 1.01 following phacoemulsification alone compared to 1.33 after one iStent implant with phacoemulsification, and 1.1 after 2 iStent implants with phacoemulsification. Compared to cataract extraction alone, iStent with cataract extraction showed a significant decrease in the number of glaucoma medications (SMD = -0.65, 95% CI: [-1.18, -0.12]). Funnel plots suggested the absence of publication bias.Both iStent implantation with concurrent phacoemulsification and phacoemulsification alone result in a significant decrease in IOP and topical glaucoma medications. In terms of both reductions, iStent with phacoemulsification significantly outperforms phacoemulsification alone

Funnel plot for pre- and post-operative IOPR% for studies comparing iStent insertion with phacoemulsification versus phacoemulsification as a solo procedure.

<p>Funnel plot for pre- and post-operative IOPR% for studies comparing iStent insertion with phacoemulsification versus phacoemulsification as a solo procedure.</p

Forest plot for pre- and post-operative number of topical glaucoma medications by follow-up (months) for iStent and simultaneous phacoemulsification group.

<p>Forest plot for pre- and post-operative number of topical glaucoma medications by follow-up (months) for iStent and simultaneous phacoemulsification group.</p

Forest plot for difference in post-operative IOPR% for studies comparing iStent insertion with phacoemulsification versus phacoemulsification as a solo procedure.

<p>Forest plot for difference in post-operative IOPR% for studies comparing iStent insertion with phacoemulsification versus phacoemulsification as a solo procedure.</p

Forest plot for difference in post-operative number of topical glaucoma medications of iStent with phacoemulsification versus phacoemulsification only.

<p>Forest plot for difference in post-operative number of topical glaucoma medications of iStent with phacoemulsification versus phacoemulsification only.</p

Reported pre- and post-operative intraocular pressure in included studies considering phacoemulsification as a solo procedure.

<p>Weighted mean reduction in IOP (IOPR%) following Phacoemulsification as a solo procedure was 31%</p><p>Reported pre- and post-operative intraocular pressure in included studies considering phacoemulsification as a solo procedure.</p

Forest plot for pre- and post-operative number of topical glaucoma medications for studies examining iStent insertion with simultaneous phacoemulsification.

<p>Forest plot for pre- and post-operative number of topical glaucoma medications for studies examining iStent insertion with simultaneous phacoemulsification.</p

PRISMA Flow Diagram for iStent with Phacoemulsification versus Phacoemulsification alone for Patients with Glaucoma and Cataract: A Meta-Analysis.

<p>PRISMA Flow Diagram for iStent with Phacoemulsification versus Phacoemulsification alone for Patients with Glaucoma and Cataract: A Meta-Analysis.</p