Unoccupied electronic states of Ge(001) 2 × 1 by constant initial band photoemission

The unoccupied electronic band structure of the Ge(001)2 × 1 surface along the \̄gGJ̄J̄' line of the surface Brillouin zone is investigated in an energy regime from the vacuum level up to about 22 eV above the valence band maximum (VBM) by applying a new constant initial band (CIB) mode of angle-resolved photoelectron spectroscopy using synchrotron radiation. In this mode final energy and photon energy are simultaneously scanned in accordance with energy and momentum conservation using a preselected dispersive initial band. We have chosen the well known occupied dangling-bond band as initial band which lies close to the uppermost bulk band at k⊥ = 0. Several bulk emission features are observed, showing good agreement with pseudopotential bands. In addition, about 13 eV above VBM we observe an emission revealing the periodicity of the reconstructed surface being attributable to a surface state. Constant initial energy spectra taken at normal emission further support its two-dimensionality

2-Arylamino-4-Amino-5-Aroylthiazoles. "One-Pot" Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization

The essential role of microtubules in mitosis makes them a major target of compounds useful for cancer therapy. In our search for potent antitumor agents, a novel series of 2-anilino-4-amino-5-aroylthiazoles was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. SAR was elucidated with various substitutions on the phenylamino and aroyl moiety at the 2- and 5-positions, respectively, of the 4-aminothiazole skeleton. Tumor cell exposure to several of these compounds led to the arrest of HeLa cells in the G2/M phase of the cell cycle and induction of apoptosis

Inter rater reliability of Pressure Ulcer Scale for Healing (PUSH) in patients with chronic leg ulcers Confiabilidad inter-observadores del Pressure Ulcer Scale for Healing (PUSH) en pacientes con úlceras crónicas en la pierna Confiabilidade interobservadores do Pressure Ulcer Scale for Healing (PUSH), em pacientes com úlceras crônicas de perna

This study aimed to evaluate the inter rater reliability of the Pressure Ulcer Scale for Healing (PUSH), in its version adapted to the Portuguese language, in patients with chronic leg ulcers. Kappa index was used for the analysis. After accomplishing ethical issues, 41 patients with ulcers were examined. A total of 49% of the ulcers were located in the right leg and 36% of them were venous ulcers. The Kappa indices (0.97 to 1.00) obtained in the comparison between the observations of the clinical nurses and the stomal therapists for all sub-scales and for total score, confirmed the tool inter rater reliability, with statistical significance (p<0.001). The PUSH instrument, in its Portuguese adapted version, showed to be reliable to the use in patients with chronic leg ulcers. Further studies should be conducted to evaluate its prospective performance.<br>El objetivo del estúdio fue probar la confiabilidad inter-observadores del Pressure Ulcer Scale for Healing (PUSH), en su versión adaptada al portugués, en pacientes con úlceras crónicas en la pierna. Para el análisis de concordancia se utilizó el Indice Kappa. Posterior a la aprobación del Comité de Ética, 41 pacientes con úlcera fueron examinados, siendo que 49% de las úlceras se localizaron a la derecha y 36% eran de etiología venosa. Los indices Kappa obtenidos (0,97 a 1,00), con un nivel significativo de p<0,001, confirmaron la confiabilidad de los inter-observadores, al obtenerse un nivel de concordancia muy bueno entre el total de las observaciones realizadas por enfermeros clínicos y especialistas en estomatología (patrón-oro), dichos valores obtenidos tanto para todas las sub escalas de PUSH como para el puntaje total. Los resultados permiten concluir que el PUSH, en su versión adaptada para el portugués, mostró confiabilidad para ser utilizado en pacientes con úlceras crónicas en miembros inferiores, debiendo ampliarse el estudio para evaluar su desempeño prospectivo.<br>Testar a confiabilidade interobservadores do Pressure Ulcer Scale for Healing (PUSH), em sua versão adaptada para o português, em pacientes com úlceras crônicas de perna foi o objetivo deste estudo. Para a análise de concordância, utilizou-se o índice Kappa. Após aprovação pelo Comitê de Ética, pacientes com úlceras (41) úlceras foram examinados, sendo que 49% das úlceras localizavam-se à direita e 36% eram de etiologia venosa. Os índices Kappa obtidos (0,97 a 1,00), com significância estatística (p<0,001), ratificaram a confiabilidade interobservadores, ao ser obtida concordância de muito boa a total entre as observações de enfermeiros clínicos e especialistas em estomaterapia (padrão-ouro), para todas as subescalas do PUSH, como para o escore total. Esses resultados permitem concluir que o PUSH, em sua versão adaptada para o português, mostrou confiabilidade para utilização em pacientes com úlceras crônicas de membros inferiores, devendo-se ampliar o estudo para avaliação de seu desempenho prospectivo