8 research outputs found
Molecular Biomarkers for the Early Detection of Ovarian Cancer
No full textOvarian cancer is the deadliest gynecological cancer, leading to over 152,000 deaths each year. A late diagnosis is the primary factor causing a poor prognosis of ovarian cancer and often occurs due to a lack of specific symptoms and effective biomarkers for an early detection. Currently, cancer antigen 125 (CA125) is the most widely used biomarker for ovarian cancer detection, but this approach is limited by a low specificity. In recent years, multimarker panels have been developed by combining molecular biomarkers such as human epididymis secretory protein 4 (HE4), ultrasound results, or menopausal status to improve the diagnostic efficacy. The risk of ovarian malignancy algorithm (ROMA), the risk of malignancy index (RMI), and OVA1 assays have also been clinically used with improved sensitivity and specificity. Ongoing investigations into novel biomarkers such as autoantibodies, ctDNAs, miRNAs, and DNA methylation signatures continue to aim to provide earlier detection methods for ovarian cancer. This paper reviews recent advancements in molecular biomarkers for the early detection of ovarian cancer
Activation of Mitochondrial ATP-Dependent Potassium Channels Protects Neurons against Ischemia-Induced Death by a Mechanism Involving Suppression of Bax Translocation and Cytochrome c
No full textUltraviolet-pumped white light emissive carbon dot based phosphors for light-emitting devices and visible light communication
No full textDual-Emissive and Color-Tunable Mn-Doped InP/ZnS Quantum Dots via a Growth-Doping Method
No full textEnvironmental Governance for the Coastal Marine Ecosystem Services of Chiloé Island (Southern Chile)
No full textThe ChiloĂ© Island, located in Southern Chile, is worldwide known for its culture, originated in the syncretism between ancestral groups and colonizers, and molded through the interactions with the isolated ecosystems and extreme weather conditions. In this chapter, we analyze the state of the island’s social-ecological systems, the drivers (direct and indirect), and the impacts. We also analyze the current modes of governance related to coastal marine ecosystems and the social effects of an event that occurred during the year 2016, known as Chilote’s May.Fil: Delgado, Luisa E.. Universidad de Chile.; ChileFil: MarĂn, Victor H.. Universidad de Chile.; ChileFil: AsĂşn, Rodrigo. Universidad de Chile.; ChileFil: Zúñiga, Claudia. Universidad de Chile.; ChileFil: Natenzon, Claudia Eleonor. Universidad de Buenos Aires. Facultad de FilosofĂa y Letras. Instituto de GeografĂa "Romualdo Ardissone"; ArgentinaFil: Castro Diaz, Ivan Ricardo. Universidad Nacional de Entre RĂos; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Paredes, Lorena D.. Universidad de Chile.; ChileFil: Caprioli, Franco. Universidad de Chile.; Chil
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
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