1,154 research outputs found
Einstein energy associated with the Friedmann -Robertson -Walker metric
Following Einstein's definition of Lagrangian density and gravitational field
energy density (Einstein, A., Ann. Phys. Lpz., 49, 806 (1916); Einstein, A.,
Phys. Z., 19, 115 (1918); Pauli, W., {\it Theory of Relativity}, B.I.
Publications, Mumbai, 1963, Trans. by G. Field), Tolman derived a general
formula for the total matter plus gravitational field energy () of an
arbitrary system (Tolman, R.C., Phys. Rev., 35(8), 875 (1930); Tolman, R.C.,
{\it Relativity, Thermodynamics & Cosmology}, Clarendon Press, Oxford, 1962));
Xulu, S.S., arXiv:hep-th/0308070 (2003)). For a static isolated system, in
quasi-Cartesian coordinates, this formula leads to the well known result , where is the
determinant of the metric tensor and is the energy momentum tensor of
the {\em matter}. Though in the literature, this is known as "Tolman Mass", it
must be realized that this is essentially "Einstein Mass" because the
underlying pseudo-tensor here is due to Einstein. In fact, Landau -Lifshitz
obtained the same expression for the "inertial mass" of a static isolated
system without using any pseudo-tensor at all and which points to physical
significance and correctness of Einstein Mass (Landau, L.D., and Lifshitz,
E.M., {\it The Classical Theory of Fields}, Pergamon Press, Oxford, 2th ed.,
1962)! For the first time we apply this general formula to find an expression
for for the Friedmann- Robertson -Walker (FRW) metric by using the same
quasi-Cartesian basis. As we analyze this new result, physically, a spatially
flat model having no cosmological constant is suggested. Eventually, it is seen
that conservation of is honoured only in the a static limit.Comment: By mistake a marginally different earlier version was loaded, now the
journal version is uploade
General moments of the inverse real Wishart distribution and orthogonal Weingarten functions
Let be a random positive definite symmetric matrix distributed according
to a real Wishart distribution and let be its inverse
matrix. We compute general moments explicitly. To do so, we employ the orthogonal Weingarten
function, which was recently introduced in the study for Haar-distributed
orthogonal matrices. As applications, we give formulas for moments of traces of
a Wishart matrix and its inverse.Comment: 29 pages. The last version differs from the published version, but it
includes Appendi
Solar Mikheyev-Smirnov-Wolfenstein Effect with Three Generations of Neutrinos
Under the assumption that the density variation of the electrons can be
approximated by an exponential function, the solar Mikheyev-Smirnov-Wolfenstein
effect is treated for three generations of neutrinos. The generalized
hypergeometric functions that result from the exact solution of this problem
are studied in detail, and a method for their numerical evaluation is
presented. This analysis plays a central role in the determination of neutrino
masses, not only the differences of their squares, under the assumption of
universal quark-lepton mixing.Comment: 22 pages, LaTeX, including 2 figure
"Turbokapitalismus versus Soziale Marktwirtschaft" - Findet ein Ausverkauf deutscher Unternehmen durch ausländische Fonds statt?
Verhindern kurzfristige Gewinninteressen von Hedge- und Private-Equity-Fonds eine solide Unternehmensstrategie und gefährden die Existenz von Traditionsunternehmen? Zu diesen Fragen fand vom 20. bis 22. Oktober 2006 unter der Leitung von Dr. Wolfgang Quaisser in der Akademie für Politische Bildung Tutzing die Tagung "Dem Raubtier auf die Zähne gefühlt: Turbokapitalismus versus Soziale Marktwirtschaft" statt. Friedrich L. Sell, Universität der Bundeswehr München, äußerte sich dort zu den Möglichkeiten des IWF, zur Stabilisierung internationaler Finanzmärkte beizutragen. Martin Hüfner, ehemals HypoVereinsbank, München, analysierte die Situation der deutschen Banken im internationalen Wettbewerb. Rüdiger von Rosen, Deutsches Aktieninstitut, Frankfurt, unterstrich, dass funktionierende Kapitalmärkte für das Wachstum und die Beschäftigungsaussichten von Volkswirtschaften eine entscheidende Voraussetzung bilden, und fragte nach der Kapitalmarktakzeptanz und insbesondere der "Akzeptanz der Aktie" in Deutschland auf Seiten der Anleger, der Unternehmen und der Politik. Für Bernd Rudolph, Universität München, übernehmen Private-Equity-Gesellschaften ebenso wie Hedgefonds "wichtige Funktionen in einem Finanzsystem, die von anderen Finanzintermediären nicht in dieser Form und nicht mit dieser Effizienz erfüllt werden können. … Wenn man von einigen zum Teil beklagenswerten Einzelfällen absieht, dann lässt sich in der Umwälzung des Finanzsystems klar ausmachen, dass mit diesen neuen Investmentvehikeln der Kapitalmarkt vervollkommnet und vervollständigt werden kann." Peter Aiello und Dieter Wermuth, Wermuth Asset Management GmbH, gaben einen Überblick über die Funtionsweise von Hedgefonds und bewerteten deren Vor- und Nachteile. Alexandra Krieger, Hans-Böckler-Stiftung, Düsseldorf, setzte sich kritisch mit dem Geschäftsmodell der Private-Equity-Fonds auseinander. Und Christoph Lütge, Universität München, stellte einige grundsätzliche Überlegungen "zur Ethik in der Marktwirtschaft"Soziale Marktwirtschaft, Kapitalismus, Übernahme, Unternehmen, Fonds, Devisenmarkt, Internationaler Finanzmarkt, Internationaler Wettbewerb, Wirtschaftsethik, Deutschland
Towards Autopoietic Computing
A key challenge in modern computing is to develop systems that address
complex, dynamic problems in a scalable and efficient way, because the
increasing complexity of software makes designing and maintaining efficient and
flexible systems increasingly difficult. Biological systems are thought to
possess robust, scalable processing paradigms that can automatically manage
complex, dynamic problem spaces, possessing several properties that may be
useful in computer systems. The biological properties of self-organisation,
self-replication, self-management, and scalability are addressed in an
interesting way by autopoiesis, a descriptive theory of the cell founded on the
concept of a system's circular organisation to define its boundary with its
environment. In this paper, therefore, we review the main concepts of
autopoiesis and then discuss how they could be related to fundamental concepts
and theories of computation. The paper is conceptual in nature and the emphasis
is on the review of other people's work in this area as part of a longer-term
strategy to develop a formal theory of autopoietic computing.Comment: 10 Pages, 3 figure
Pain outcomes in patients with bone metastases from advanced cancer: assessment and management with bone-targeting agents
Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients. The most commonly used pain assessment instruments are visual analogue scales, a single-item measure, and the Brief Pain Inventory Questionnaire-Short Form. The World Health Organization analgesic ladder and the Analgesic Quantification Algorithm are used to evaluate analgesic use. Bone-targeting agents, such as denosumab or bisphosphonates, prevent skeletal complications (i.e., radiation to bone, pathologic fractures, surgery to bone, and spinal cord compression) and can also improve pain outcomes in patients with metastatic bone disease. We have reviewed pain outcomes and analgesic use and reported pain data from an integrated analysis of randomized controlled studies of denosumab versus the bisphosphonate zoledronic acid (ZA) in patients with bone metastases from advanced solid tumors. Intravenous bisphosphonates improved pain outcomes in patients with bone metastases from solid tumors. Compared with ZA, denosumab further prevented pain worsening and delayed the need for treatment with strong opioids. In patients with no or mild pain at baseline, denosumab reduced the risk of increasing pain severity and delayed pain worsening along with the time to increased pain interference compared with ZA, suggesting that use of denosumab (with appropriate calcium and vitamin D supplementation) before patients develop bone pain may improve outcomes. These data also support the use of validated pain assessments to optimize treatment and reduce the burden of pain associated with metastatic bone disease
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning.
METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm.
RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function.
CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning.
METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm.
RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function.
CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning
"Open Innovation" and "Triple Helix" Models of Innovation: Can Synergy in Innovation Systems Be Measured?
The model of "Open Innovations" (OI) can be compared with the "Triple Helix
of University-Industry-Government Relations" (TH) as attempts to find surplus
value in bringing industrial innovation closer to public R&D. Whereas the firm
is central in the model of OI, the TH adds multi-centeredness: in addition to
firms, universities and (e.g., regional) governments can take leading roles in
innovation eco-systems. In addition to the (transversal) technology transfer at
each moment of time, one can focus on the dynamics in the feedback loops. Under
specifiable conditions, feedback loops can be turned into feedforward ones that
drive innovation eco-systems towards self-organization and the auto-catalytic
generation of new options. The generation of options can be more important than
historical realizations ("best practices") for the longer-term viability of
knowledge-based innovation systems. A system without sufficient options, for
example, is locked-in. The generation of redundancy -- the Triple Helix
indicator -- can be used as a measure of unrealized but technologically
feasible options given a historical configuration. Different coordination
mechanisms (markets, policies, knowledge) provide different perspectives on the
same information and thus generate redundancy. Increased redundancy not only
stimulates innovation in an eco-system by reducing the prevailing uncertainty;
it also enhances the synergy in and innovativeness of an innovation system.Comment: Journal of Open Innovations: Technology, Market and Complexity, 2(1)
(2016) 1-12; doi:10.1186/s40852-016-0039-
Palaeoproterozoic magnesite: lithological and isotopic evidence for playa/sabkha environments
Magnesite forms a series of 1- to 15-m-thick beds within the approximate to2.0 Ga (Palaeoproterozoic) Tulomozerskaya Formation, NW Fennoscandian Shield, Russia. Drillcore material together with natural exposures reveal that the 680-m-thick formation is composed of a stromatolite-dolomite-'red bed' sequence formed in a complex combination of shallow-marine and non-marine, evaporitic environments. Dolomite-collapse breccia, stromatolitic and micritic dolostones and sparry allochemical dolostones are the principal rocks hosting the magnesite beds. All dolomite lithologies are marked by delta C-13 values from +7.1 parts per thousand to +11.6 parts per thousand (V-PDB) and delta O-18 ranging from 17.4 parts per thousand to 26.3 parts per thousand (V-SMOW). Magnesite occurs in different forms: finely laminated micritic; stromatolitic magnesite; and structureless micritic, crystalline and coarsely crystalline magnesite. All varieties exhibit anomalously high delta C-13 values ranging from +9.0 parts per thousand to +11.6 parts per thousand and delta O-18 values of 20.0-25.7 parts per thousand. Laminated and structureless micritic magnesite forms as a secondary phase replacing dolomite during early diagenesis, and replaced dolomite before the major phase of burial. Crystalline and coarsely crystalline magnesite replacing micritic magnesite formed late in the diagenetic/metamorphic history. Magnesite apparently precipitated from sea water-derived brine, diluted by meteoric fluids. Magnesitization was accomplished under evaporitic conditions (sabkha to playa lake environment) proposed to be similar to the Coorong or Lake Walyungup coastal playa magnesite. Magnesite and host dolostones formed in evaporative and partly restricted environments; consequently, extremely high delta C-13 values reflect a combined contribution from both global and local carbon reservoirs. A C- 13-rich global carbon reservoir (delta C-13 at around +5 parts per thousand) is related to the perturbation of the carbon cycle at 2.0 Ga, whereas the local enhancement in C-13 (up to +12 parts per thousand) is associated with evaporative and restricted environments with high bioproductivity
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