172 research outputs found
Phase distortions of attosecond pulses produced by resonance-enhanced high harmonic generation
Resonant enhancement of high harmonic generation can be obtained in plasmas
containing ions with strong radiative transitions resonant with harmonic
orders. The mechanism for this enhancement is still debated. We perform the
first temporal characterization of the attosecond emission from a tin plasma
under near-resonant conditions for two different resonance detunings. We show
that the resonance considerably changes the relative phase of neighbouring
harmonics. For very small detunings, their phase locking may even be lost,
evidencing strong phase distortions in the emission process and a modified
attosecond structure. These features are well reproduced by our simulations,
allowing their interpretation in terms of the phase of the recombination dipole
moment
Quantum picturalism for topological cluster-state computing
Topological quantum computing is a way of allowing precise quantum
computations to run on noisy and imperfect hardware. One implementation uses
surface codes created by forming defects in a highly-entangled cluster state.
Such a method of computing is a leading candidate for large-scale quantum
computing. However, there has been a lack of sufficiently powerful high-level
languages to describe computing in this form without resorting to single-qubit
operations, which quickly become prohibitively complex as the system size
increases. In this paper we apply the category-theoretic work of Abramsky and
Coecke to the topological cluster-state model of quantum computing to give a
high-level graphical language that enables direct translation between quantum
processes and physical patterns of measurement in a computer - a "compiler
language". We give the equivalence between the graphical and topological
information flows, and show the applicable rewrite algebra for this computing
model. We show that this gives us a native graphical language for the design
and analysis of topological quantum algorithms, and finish by discussing the
possibilities for automating this process on a large scale.Comment: 18 pages, 21 figures. Published in New J. Phys. special issue on
topological quantum computin
Attosecond emission from chromium plasma
International audienceWe present the first measurement of the attosecond emission generated from underdense plasma produced on a solid target. We generate high-order harmonics of a femtosecond Ti:sapphire laser focused in a weakly ionized underdense chromium plasma. Using the " Reconstruction of Attosecond Beating by Interference of Two-photon Transitions " (RABITT) technique, we show that the 11 th to the 19 th harmonic orders form in the time domain an attosecond pulse train with each pulse having 300 as duration, which is only 1.05 times the theoretical Fourier transform limit. Measurements reveal a very low positive group delay dispersion of 4200 as 2. Beside its fundamental interest, high-order harmonic generation in plasma plumes could thus provide an intense source of attosecond pulses for applications
Etude histologique des lésions du syndrome hémorragique des bovidés bretons
Guilhon Jean, Drieux Henri, Gasse H., Perdrix Jean, Julou L. Étude histologique des lésions du syndrome hémorragique des Bovidés bretons. In: Bulletin de l'Académie Vétérinaire de France tome 103 n°4, 1950. pp. 181-184
Computational depth complexity of measurement-based quantum computation
We prove that one-way quantum computations have the same computational power
as quantum circuits with unbounded fan-out. It demonstrates that the one-way
model is not only one of the most promising models of physical realisation, but
also a very powerful model of quantum computation. It confirms and completes
previous results which have pointed out, for some specific problems, a depth
separation between the one-way model and the quantum circuit model. Since
one-way model has the same computational power as unbounded quantum fan-out
circuits, the quantum Fourier transform can be approximated in constant depth
in the one-way model, and thus the factorisation can be done by a polytime
probabilistic classical algorithm which has access to a constant-depth one-way
quantum computer. The extra power of the one-way model, comparing with the
quantum circuit model, comes from its classical-quantum hybrid nature. We show
that this extra power is reduced to the capability to perform unbounded
classical parity gates in constant depth.Comment: 12 page
Non-muscle Myosin II reactivation and cytoskeletal remodelling as a new vulnerability in therapy-resistant melanoma
Trabajo presentado en el 3rd ASEICA Educational Symposium, celebrado en modalidad virtual del 23 al 25 de noviembre de 2021.MAPK-targeted therapies (MAPKi) and immune checkpoint blockers (ICB) improve survival of subsets of melanoma patients. However, therapy resistance is a persistent problem. Cross-resistance to MAPKi and ICB may be driven by common transcriptomic alterations in pathways controlling invasion and metastasis. Using phosphoproteomic and transcriptomic analyses, we find that adaptation to treatment and acquisition of resistance to MAPKi involve cytoskeletal remodelling and changes in levels in the ROCK-non-muscle Myosin II (NMII) pathway, which is essential for cancer invasion and metastasis. NMII activity is decreased shortly after MAPK is blocked. However, persister cells promptly restore NMII activity to increase survival, and this becomes a vulnerability, since survival of MAPKi- and ICB-resistant cells is highly dependent on ROCK-NMII. Efficacy of MAPKi and ICB can be improved by combination with ROCK inhibitors, which have a dual action by impairing melanoma cell survival (through induction of lethal reactive oxygen species and unresolved DNA damage) and reducing myeloid- and lymphoid-driven immunosuppression, ultimately overcoming cross-resistance in vivo. In human tumours, high ROCK-NMII levels identify MAPKi-, ICB-resistant melanomas, and treatment-naïve melanomas with worse prognosis. Therefore, a subset of MAPKi- and ICB-resistant melanomas is more susceptible to ROCK-NMII blockade, suggesting clinical opportunities for combination therapies
The Myosin II cytoskeleton as a new vulnerability in therapy-resistant melanoma
Trabajo presentado en VIB Conference: Tumor Heterogeneity, Plasticity and Therapy, celebrado en modalidad virtual del 05 al 06 de mayo de 2021.MAPK-targeted therapies (MAPKi) and immune checkpoint blockers (ICB) improve survival of subsets of melanoma patients. However, therapy resistance is a persistent problem. Cross-resistance to MAPKi and ICB has been suggested to be driven, in part, by common transcriptomic alterations in pathways controlling invasion and metastasis. We find that adaptation to treatment and acquisition of resistance to MAPKi involve cytoskeletal remodelling and changes in expression levels in the ROCK-Myosin II pathway, which plays a key role in cancer invasion and metastasis. Myosin II activity is decreased shortly after MAPK is blocked. However, resistant cells promptly restore Myosin II activity to increase survival, and this becomes a vulnerability, since survival of MAPKi- and ICB-resistant cells is highly dependent on ROCK-Myosin II. Efficacy of MAPKi and ICB can be improved by combination with ROCK inhibitors, which have a dual action by impairing melanoma cell survival (through induction of lethal reactive oxygen species and unresolved DNA damage) and myeloid- and lymphoiddriven immunosuppression, overcoming cross-resistance. In human tumours, high ROCK-Myosin II activity and their associated transcriptome identify MAPKi-, ICBresistant melanomas, and treatment-naïve melanomas with worse prognosis. Therefore, a subset of MAPKi- and ICB-resistant melanomas is intrinsically more susceptible to ROCK-Myosin II inhibition, suggesting clinical opportunities for combination therapies
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