Heteranthery in Clarkia: pollen performance of dimorphic anthers contradicts expectations.

Premise of the studyWild plant species that require the services of pollen-feeding insects for reliable pollination may evolve features that attract and reward their mutualistic partners. Heterantherous species have been proposed to exhibit a "division of labor" whereby "feeding anthers" (which produce pollen that may be consumed by an insect) are distinguished from "reproductive anthers" (which produce pollen more likely to contribute to reproduction). In some heterantherous species, including Clarkia unguiculata (Onagraceae), these two anther types differ with respect to stamen length, anther size, pollen production, and pollen color.MethodsThe primary goal of this study was to test one component of the "division of labor" hypothesis by comparing the performance of the pollen produced by each type of anther in C. unguiculata. To achieve this goal, under greenhouse conditions, we hand pollinated and assessed pollen performance (using epifluorescence microscopy) within ~228 flowers.Key resultsThe pollen produced by the two anther types differed significantly with respect to both stigma and style penetration. The inner series of anthers produce pollen with higher performance than the outer series of longer, dark red anthers.ConclusionsThese findings contradict previous descriptions of the genus, reporting that the inner diminutive series of anthers in Clarkia produce "abortive and nonfunctional" pollen. We outline the future research required to demonstrate the ecological function of heteranthery in this iconic wildflower group

Workers' Choice on Pension Schemes: an Assessment of the Italian TFR Reform Through Theory and Simulations

In this paper we aim at providing a theoretical framework to model workers’ choice problem of switching between different pension schemes. This choice problem is common in several countries that have reformed their social security system in the last decades. Although with some specific features, such process is currently affecting private sector employees in Italy, since the reform of the TFR mechanism in 2007. This reform basically allows workers to choose between a scheme directly managed by the firms and an external defined contribution scheme. In their decision workers not only have to weight out the different pros and cons that different schemes offer but they also have to consider the effect that their choice exerts on the financial structure of the firm they work in. Once we have formalized this decision problem, we carry out some simulations in order to replicate the Italian data and to shed some light on the outcomes of the Italian reform

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism

Peer reviewedPublisher PD

Response of the low ionosphere to X-ray and Lyman-a solar flare emissions

International audience[1] Using soft X-ray measurements from detectors onboard the Geostationary Operational Environmental Satellite (GOES) and simultaneous high-cadence Lyman-a observations from the Large Yield Radiometer (LYRA) onboard the Project for On-Board Autonomy 2 (PROBA2) ESA spacecraft, we study the response of the lower part of the ionosphere, the D region, to seven moderate to medium-size solar flares that occurred in February and March of 2010. The ionospheric disturbances are analyzed by monitoring the resulting sub-ionospheric wave propagation anomalies detected by the South America Very Low Frequency (VLF) Network (SAVNET). We find that the ionospheric disturbances, which are characterized by changes of the VLF wave phase, do not depend on the presence of Lyman-a radiation excesses during the flares. Indeed, Lyman-a excesses associated with flares do not produce measurable phase changes. Our results are in agreement with what is expected in terms of forcing of the lower ionosphere by quiescent Lyman-a emission along the solar activity cycle. Therefore, while phase changes using the VLF technique may be a good indicator of quiescent Lyman-a variations along the solar cycle, they cannot be used to scale explosive Lyman-a emission during flares

Phaseolus vulgaris L. Extract: Alpha-amylase inhibition against metabolic syndrome in mice

To examine the effects of the alpha-amylase inhibitor isoform 1 called phaseolamin, a standardized extract from white kidney beans (Phaseolus vulgaris L) was tested against the hallmarks of metabolic syndrome. The efficacy of a per os repeated treatment with P. vulgaris extract (500 mg/kg) was compared with metformin (100 mg/kg) and atorvastatin (10 mg/kg) in a model of metabolic syndrome evoked by prolonged high fat diet (HFD; week 1 to week 19) in C57BL/6 mice. Bean extract and compounds administration started after metabolic syndrome establishment (week 11). P. vulgaris extract reduced the body weight overtime, as well as effectively lowered glycaemia, triglycerides, and cholesterol. On week 19, bean extract normalized the HFD-evoked tolerance to glucose and insulin. According to the phytochemical characterization, it inhibited the alpha-amylase activity. Animals treated with the extract were rescued from motor impairments and nociceptive threshold alterations induced by HFD. Specific organs analysis revealed that P. vulgaris extract decreased hepatic steatosis and lipid peroxidation in liver. It protected the heart from HFD oxidative alterations increasing the expression of the detoxifying enzymes catalase and glutathione reductase, and normalizing NADH dehydrogenase level. The histological analysis of aorta showed a protection about the development of fatty streaks in the muscular layers. In conclusion, a prolonged treatment with the standardized extract of P. vulgaris significantly reduced several pathological features related to a metabolic syndrome-like condition; a multifactorial approach that candidates this vegetal product as a possible therapeutic option against metabolic syndrome

On Hoyle-Narlikar-Wheeler mechanism of vibration energy powered magneto-dipole emission of neutron stars

We revisit the well-known Hoyle-Narlikar-Wheeler proposition that neutron star emerging in the magnetic-flux-conserving process of core-collapse supernova can convert the stored energy of Alfven vibrations into power of magneto-dipole radiation. We show that the necessary requirement for the energy conversion is the decay of internal magnetic field. In this case the loss of vibration energy of the star causes its vibration period, equal to period of pulsating emission, to lengthen at a rate proportional to the rate of magnetic field decay. These prediction of the model of vibration powered neutron star are discussed in juxtaposition with data on pulsating emission of magnetars whose radiative activity is generally associated with the decay of ultra strong magnetic field.Comment: Accepted for publication in Astrophysics & Space Scienc

Clinical and Molecular Assessment in a Female with Fragile X Syndrome and Tuberous Sclerosis.

Fragile X syndrome (FXS) and tuberous sclerosis (TSC) are genetic disorders that result in intellectual disability and an increased prevalence of autism spectrum disorders (ASD). While the clinical presentation of each disorder is distinct, the molecular causes are linked to a disruption in the mTORC1 (mammalian Target of Rapamycin Complex 1) and ERK1/2 (Extracellular signal-Regulated Kinase) signaling pathways. We assessed the clinical and molecular characteristics of an individual seen at the UC Davis MIND Institute with a diagnosis of FXS and TSC. Clinical evaluation of physical, behavioral, and cognitive impairments were performed. Additionally, total and phosphorylated proteins along the mTORC1 and ERK1/2 pathways were measured in primary fibroblast cell lines from the proband. In this case the phenotypic effects that result in a human with both FXS and TSC are shown to be severe. Changes in mTORC1 and ERK1/2 signaling proteins and global protein synthesis were not found to be noticeably different between four cohorts (typically developing, FMR1 full mutation, FMR1 full mutation and TSC1 loss of function mutation, and TSC1 loss of function mutation); however cohort sizes prevented stringent comparisons. It has previously been suggested that disruption of the mTORC1 pathway was reciprocal in TSC and FXS double knock-out mouse models so that the regulation of these pathways were more similar to wild-type mice compared to mice harboring a Fmr1(-/y) or Tsc2(-/+) mutation alone. However, in this first reported case of a human with a diagnosis of both FXS and TSC, substantial clinical impairments, as a result of these two disorders were observed. Differences in the mTORC and ERK1/2 pathways were not clearly established when compared between individuals with either disorder, or both