How to tell if your cloud files are vulnerable to drive crashes

This paper presents a new challenge--verifying that a remote server is storing a file in a fault-tolerant manner, i.e., such that it can survive hard-drive failures. We describe an approach called the Remote Assessment of Fault Tolerance (RAFT). The key technique in a RAFT is to measure the time taken for a server to respond to a read request for a collection of file blocks. The larger the number of hard drives across which a file is distributed, the faster the read-request response. Erasure codes also play an important role in our solution. We describe a theoretical framework for RAFTs and offer experimental evidence that RAFTs can work in practice in several settings of interest

A CASE STUDY - DETERMINING THE MUSCLE IMBALANCE OF THE JUNIORS 3 IN HURDLES EVENTS THROUGH BIODEX SYSTEM 4 PROTM

A case study was undertaken to determine the agonist - antagonist ratio of the lower limb of the junior athletes three according with the technical demands of the leading leg and trail leg from hurdles events. The leading leg during the hurdles events is using the flexion/extension of the knee while the trail leg movements are more complex including: abduction of the hip, shoulder external rotation. Our study consists in a total of five variables tested using Biodex System ProTM such as: knee extension/flexion, ankle plantar/dorsiflexion, hip extension /flexion, hip abduction / adduction and shoulder internal / external rotation at different speeds (60°/s 120°/s, 180°/s. 300°/s, 450 °/s). We have compared speeds for each variable to determine differences between right and left leg. In addition, this study aimed to create a more objective image of the agonist - antagonist ratio for the leading/trail leg during hurdles race for junior athletes 3

Institutional determinants of informal payments for health services : an exploratory analysis across 117 countries

Healthcare accessibility and equity remain important issues, as corruption in the form of informal payments is still prevalent in many countries across the world. This study employs a panel data analysis over the 2006–2013 period to explore the role of different institutional factors in explaining the prevalence of informal payments. Covering 117 countries, our findings confirm the significant role of both formal and informal institutions. Good governance, a higher trust among individuals, and a higher commitment to tackling corruption are associated with diminishing informal payments. In addition, higher shares of private finance, such as out-of-pocket and domestic private health expenditure, are also correlated with a lower prevalence of informal payments. In policy terms, this displays how correcting institutional imperfections may be among the most efficient ways to tackle informal payments in healthcare

Transition from ballistic to diffusive behavior of graphene ribbons in the presence of warping and charged impurities

We study the effects of the long-range disorder potential and warping on the conductivity and mobility of graphene ribbons using the Landauer formalism and the tight-binding p-orbital Hamiltonian. We demonstrate that as the length of the structure increases the system undergoes a transition from the ballistic to the diffusive regime. This is reflected in the calculated electron density dependencies of the conductivity and the mobility. In particular, we show that the mobility of graphene ribbons varies as mu(n) n^(-lambda), with 0<lambda<0.5. The exponent lambda depends on the length of the system with lambda=0.5 corresponding to short structures in the ballistic regime, whereas the diffusive regime lambda=0 (when the mobility is independent on the electron density) is reached for sufficiently long structures. Our results can be used for the interpretation of experimental data when the value of lambda can be used to distinguish the transport regime of the system (i.e. ballistic, quasi-ballistic or diffusive). Based on our findings we discuss available experimental results

Novel Role for the Golgi Membrane Protein TMEM165 in Control of Migration and Invasion for Breast Carcinoma

The TMEM165 gene encodes for a multiple pass membrane protein localized in the Golgi that has been linked to congenital disorders of glycosylation. The TMEM165 protein is a putative ion transporter that regulates H+/Ca++/Mn++ homeostasis and pH in the Golgi. Previously, we identified TMEM165 as a potential biomarker for breast carcinoma in a glycoproteomic study using late stage invasive ductal carcinoma tissues with patient-matched adjacent normal tissues. The TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry. Our hypothesis is that the TMEM165 protein confers a growth advantage to breast cancer. In this preliminary study we have investigated the expression of TMEM165 in earlier stage invasive ductal carcinoma and ductal carcinoma in situ cases. We created a CRISPR/Cas9 knockout of TMEM165 in the human invasive breast cancer cell line MDAMB231. Our results indicate that removal of TMEM165 in these cells results in a significant reduction of cell migration, tumor growth, and tumor vascularization in vivo. Furthermore, we find that TMEM165 expression alters the glycosylation of breast cancer cells and these changes promote the invasion and growth of breast cancer by altering the expression levels of key glycoproteins involved in regulation of the epithelial to mesenchymal transition such as E-cadherin. These studies illustrate new potential functions for this Golgi membrane protein in the control of breast cancer growth and invasion