Colorectal Cancer Brochure Development for African Americans

Introduction: African Americans are more likely to die from colorectal cancer (CRC) than any other racial/ethnic group in the United States. Unfortunately, African Americans are also less likely to undergo screening for CRC than their White counterparts. Focus groups methodology was used to refine educational brochures designed to increase CRC screening among African Americans. Methods: Two series of focus groups were completed, with a total of seven groups and 39 participants. Six different brochures (stage-matched and culturally sensitive) designed to promote CRC screening among African Americans were evaluated. Results: All participants thought that the brochures motivated them to talk with their health care providers about screening. Cost, pain, medical mistrust and fear were identified as major barriers and the brochures were modified to address these concerns. Conclusions: Focus groups methodology with African Americans can be used to inform brochures designed to increase African Americans CRC screening that addresses their major concerns

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice

BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense investigation. Here, expanding upon pilot gene expression studies, we have further analyzed the relationship between Na+/K+ ATPase and amyloid using APP+PS1 transgenic mice, a model that develops amyloid plaques and memory deficits in the absence of tangle formation and neuronal or synaptic loss. RESULTS: We report that in addition to decreased mRNA expression, there was decreased overall Na+/K+ ATPase enzyme activity in the amyloid-containing hippocampi of the APP+PS1 mice (although not in the amyloid-free cerebellum). In addition, dual immunolabeling revealed an absence of Na+/K+ ATPase staining in a zone surrounding congophilic plaques that was occupied by dystrophic neurites. We also demonstrate that cerebral Na+/K+ ATPase activity can be directly inhibited by high concentrations of soluble Aβ. CONCLUSIONS: The data suggest that the reductions in Na+/K+ ATPase activity in Alzheimer tissue may not be purely secondary to neuronal loss, but may results from direct effects of amyloid on this enzyme. This disruption of ion homeostasis and osmotic balance may interfere with normal electrotonic properties of dendrites, blocking intraneuronal signal processing, and contribute to neuritic dystrophia. These results suggest that therapies aimed at enhancing Na+/K+ ATPase activity in AD may improve symptoms and/or delay disease progression

Spin anisotropy of the resonance in superconducting FeSe0.5Te0.5

We have used polarized-neutron inelastic scattering to resolve the spin fluctuations in superconducting FeSe0.5Te0.5 into components parallel and perpendicular to the layers. A spin resonance at an energy of 6.5 meV is observed to develop below T_c in both fluctuation components. The resonance peak is anisotropic, with the in-plane component slightly larger than the out-of-plane component. Away from the resonance peak the magnetic fluctuations are isotropic in the energy range studied. The results are consistent with a dominant singlet pairing state with s^{\pm} symmetry, with a possible minority component of different symmetry.Comment: 5 pages, 4 figure

Testing the nature of S0 galaxies using planetary nebula kinematics in NGC 1023

We investigate the manner in which lenticular galaxies are formed by studying their stellar kinematics: an S0 formed from a fading spiral galaxy should display similar cold outer disc kinematics to its progenitor, while an S0 formed in a minor merger should be more dominated by random motions. In a pilot study to attempt to distinguish between these scenarios, we have measured the planetary nebula (PN) kinematics of the nearby S0 system NGC 1023. Using the Planetary Nebula Spectrograph, we have detected and measured the line-of-sight velocities of 204 candidate PNe in the field of this galaxy. Out to intermediate radii, the system displays the kinematics of a normal rotationally-supported disc system. After correction of its rotational velocities for asymmetric drift, the galaxy lies just below the spiral galaxy Tully-Fisher relation, as one would expect for a fading system. However, at larger radii the kinematics undergo a gradual but major transition to random motion with little rotation. This transition does not seem to reflect a change in the viewing geometry or the presence of a distinct halo component, since the number counts of PNe follow the same simple exponential decline as the stellar continuum with the same projected disc ellipticity out to large radii. The galaxy's small companion, NGC 1023A, does not seem to be large enough to have caused the observed modification either. This combination of properties would seem to indicate a complex evolutionary history in either the transition to form an S0 or in the past life of the spiral galaxy from which the S0 formed. More data sets of this type from both spirals and S0s are needed in order to definitively determine the relationship between these types of system.Comment: Accepted for publication in MNRAS. Version with full resolution figure 1 can be found at http://www.nottingham.ac.uk/~ppzmrm/N1023_PNS.accepted.pd

Dark-Matter Content of Early-Type Galaxies with Planetary Nebulae

We examine the dark matter properties of nearby early-type galaxies using planetary nebulae (PNe) as mass probes. We have designed a specialised instrument, the Planetary Nebula Spectrograph (PN.S) operating at the William Herschel telescope, with the purpose of measuring PN velocities with best efficiency. The primary scientific objective of this custom-built instrument is the study of the PN kinematics in 12 ordinary round galaxies. Preliminary results showing a dearth of dark matter in ordinary galaxies (Romanowsky et al. 2003) are now confirmed by the first complete PN.S datasets. On the other hand early-type galaxies with a "regular" dark matter content are starting to be observed among the brighter PN.S target sample, thus confirming a correlation between the global dark-to-luminous mass virial ratio (f_DM=M_DM/M_star) and the galaxy luminosity and mass.Comment: 5 pages, 2 figures. To appear in the proceedings of the IAU Symposium 244 "Dark Galaxies and Lost Baryons", Cardiff 25-29 June 2007, eds. J.I. Davies & M.J. Disne

Outskirts of Nearby Disk Galaxies: Star Formation and Stellar Populations

The properties and star formation processes in the far-outer disks of nearby spiral and dwarf irregular galaxies are reviewed. The origin and structure of the generally exponential profiles in stellar disks is considered to result from cosmological infall combined with a non-linear star formation law and a history of stellar migration and scattering from spirals, bars, and random collisions with interstellar clouds. In both spirals and dwarfs, the far-outer disks tend to be older, redder and thicker than the inner disks, with the overall radial profiles suggesting inside-out star formation plus stellar scattering in spirals, and outside-in star formation with a possible contribution from scattering in dwarfs. Dwarf irregulars and the far-outer parts of spirals both tend to be gas dominated, and the gas radial profile is often non-exponential although still decreasing with radius. The ratio of H-alpha to far-UV flux tends to decrease with lower surface brightness in these regions, suggesting either a change in the initial stellar mass function or the sampling of that function, or a possible loss of H-alpha photons.Comment: 20 pages, 8 figures, Invited review, Book chapter in "Outskirts of Galaxies", Eds. J. H. Knapen, J. C. Lee and A. Gil de Paz, Astrophysics and Space Science Library, Springer, in pres

Convergence Characteristics of the Cumulant Expansion for Fourier Path Integrals

The cumulant representation of the Fourier path integral method is examined to determine the asymptotic convergence characteristics of the imaginary-time density matrix with respect to the number of path variables $N$ included. It is proved that when the cumulant expansion is truncated at order $p$, the asymptotic convergence rate of the density matrix behaves like $N^{-(2p+1)}$. The complex algebra associated with the proof is simplified by introducing a diagrammatic representation of the contributing terms along with an associated linked-cluster theorem. The cumulant terms at each order are expanded in a series such that the the asymptotic convergence rate is maintained without the need to calculate the full cumulant at order $p$. Using this truncated expansion of each cumulant at order $p$, the numerical cost in developing Fourier path integral expressions having convergence order $N^{-(2p+1)}$ is shown to be approximately linear in the number of required potential energy evaluations making the method promising for actual numerical implementation.Comment: 47 pages, 2 figures, submitted to PR

Intracluster stellar population properties from N-body cosmological simulations -- I. Constraints at z=0z=0

We use a high resolution collisionless simulation of a Virgo--like cluster in a $\Lambda$CDM cosmology to determine the velocity and clustering properties of the diffuse stellar component in the intracluster region at the present epoch. The simulated cluster builds up hierarchically and tidal interactions between member galaxies and the cluster potential produce a diffuse stellar component free-flying in the intracluster medium. Here we adopt an empirical scheme to identify tracers of the stellar component in the simulation and hence study its properties. We find that at $z=0$ the intracluster stellar light is mostly unrelaxed in velocity space and clustered in structures whose typical clustering radii are about 50 kpc at R=400--500 kpc from the cluster center, and predict the radial velocity distribution expected in spectroscopic follow-up surveys. Finally, we compare the spatial clustering in the simulation with the properties of the Virgo intracluster stellar population, as traced by ongoing intracluster planetary nebulae surveys in Virgo. The preliminary results indicate a substantial agreement with the observed clustering properties of the diffuse stellar population in Virgo.Comment: 39 pages, 10 figures, 8 tables, in press on ApJ. Bad image quality for some figures because resizing is neede

Intracluster stars in the Virgo cluster core

We have investigated the properties of the diffuse light in the Virgo cluster core region, based on the detection of intracluster planetary nebulae (PNe) in four fields. We eliminate the bias from misclassified faint continuum objects, using improved Monte Carlo simulations, and the contaminations by high redshift Ly$\alpha$ galaxies, using the Ly$\alpha$ luminosity function in blank fields. Recent spectroscopic observations confirm that our photometric PN samples are well-understood. We find that the diffuse stellar population in the Virgo core region is inhomogeneous on scales of 30'-90': there exist significant field-to-field variations in the number density of PNe and the inferred amount of intracluster light, with some empty fields, some fields dominated by extended Virgo galaxy halos, and some fields dominated by the true intracluster component. There is no clear trend with distance from M87. The mean surface luminosity density, its rms variation, and the mean surface brightness of diffuse light in our 4 fields are $\Sigma_B = 2.7 x 10^{6}$ L$_{B\odot}$ arcmin$^{-2}$, ${rms} = 2.1 \times 10^{6}$ L$_{B\odot}$ arcmin$^{-2}$, and $\bar{\mu}_{B}=29.0$ mag arcsec$^{-2}$ respectively. Our results indicate that the Virgo cluster is a dynamically young environment, and that the intracluster component is associated at least partially with local physical processes like galaxy interactions or harassment. We also argue, based on kinematic evidence, that the so-called 'over-luminous' PNe in the halo of M84 are dynamically associated with this galaxy, and must thus be brighter than and part of a different stellar population from the normal PN population in elliptical galaxies.Comment: 31 pages, 6 figure. In press on the Astronomical Journa