An annotated list of shells from northern Michigan

http://deepblue.lib.umich.edu/bitstream/2027.42/56481/1/OP042.pd

The varieties of Planorbis campanulatus Say

http://deepblue.lib.umich.edu/bitstream/2027.42/56619/1/OP180.pd

Notes on the internal lamellae of Carychium

http://deepblue.lib.umich.edu/bitstream/2027.42/56567/1/OP128.pd

Note on Oreohelix idahoensis baileyi Bartsch

http://deepblue.lib.umich.edu/bitstream/2027.42/56518/1/OP079.pd

Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus.

BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic injury and infection/inflammation. Maternal infection/inflammation may be associated with the induction of placental cytokines that could result in increased fetal proinflammatory cytokine exposure, and development of neonatal neurologic injury. Therefore, we sought to explore the mechanism by which maternal infection may produce a placental inflammatory response. We specifically examined rat placental cytokine production and activation of the Toll-like receptor 4 (TLR4) pathway in response to lipopolysaccharide exposure at preterm and near-term gestational ages.MethodsPreterm (e16) or near-term (e20) placental explants from pregnant rats were treated with 0, 1, or 10 μg/mL lipopolysaccharide. Explant integrity was assessed by lactate dehydrogenase assay. Interleukin-6 and tumor necrosis alpha levels were determined using enzyme-linked immunosorbent assay kits. TLR4 and phosphorylated nuclear factor kappa light chain enhancer of activated B cells (NFκB) protein expression levels were determined by Western blot analysis.ResultsAt both e16 and e20, lactate dehydrogenase levels were unchanged by treatment with lipopolysaccharide. After exposure to lipopolysaccharide, the release of interleukin-6 and tumor necrosis alpha from e16 placental explants increased by 4-fold and 8-9-fold, respectively (P < 0.05 versus vehicle). Conversely, interleukin-6 release from e20 explants was not significantly different compared with vehicle, and tumor necrosis alpha release was only 2-fold higher (P < 0.05 versus vehicle) following exposure to lipopolysaccharide. Phosphorylated NFκB protein expression was significantly increased in the nuclear fraction from placental explants exposed to lipopolysaccharide at both e16 and e20, although TLR4 protein expression was unaffected.ConclusionLipopolysaccharide induces higher interleukin-6 and tumor necrosis alpha expression at e16 versus e20, suggesting that preterm placentas may have a greater placental cytokine response to lipopolysaccharide infection. Furthermore, increased phosphorylated NFκB indicates that placental cytokine induction may occur by activation of the TLR4 pathway

Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds.

Hundreds of trials are being conducted to evaluate combination of newer targeted drugs as well as immunotherapy. Our aim was to compare efficacy and safety of combination versus single non-cytotoxic anticancer agents. We searched PubMed (01/01/2001 to 03/06/2018) (and, for immunotherapy, ASCO and ESMO abstracts (2016 through March 2018)) for randomized clinical trials that compared a single non-cytotoxic agent (targeted, hormonal, or immunotherapy) versus a combination with another non-cytotoxic partner. Efficacy and safety endpoints were evaluated in a meta-analysis using a linear mixed-effects model (guidelines per PRISMA Report).We included 95 randomized comparisons (single vs. combination non-cytotoxic therapies) (59.4%, phase II; 41.6%, phase III trials) (29,175 patients (solid tumors)). Combinations most frequently included a hormonal agent and a targeted small molecule (23%). Compared to single non-cytotoxic agents, adding another non-cytotoxic drug increased response rate (odds ratio [OR]=1.61, 95%CI 1.40-1.84)and prolonged progression-free survival (hazard ratio [HR]=0.75, 95%CI 0.69-0.81)and overall survival (HR=0.87, 95%CI 0.81-0.94) (all p<0.001), which was most pronounced for the association between immunotherapy combinations and longer survival. Combinations also significantlyincreased the risk of high-grade toxicities (OR=2.42, 95%CI 1.98-2.97) (most notably for immunotherapy and small molecule inhibitors) and mortality at least possibly therapy related (OR: 1.33, 95%CI 1.15-1.53) (both p<0.001) (absolute mortality = 0.90% (single agent) versus 1.31% (combinations)) compared to single agents. In conclusion, combinations of non-cytotoxic drugs versus monotherapy in randomized cancer clinical trials attenuated safety, but increased efficacy, with the balance tilting in favor of combination therapy, based on the prolongation in survival

Interferometric Detection of Pinned Interactions in Bismuth-Substituted Iron Garnet

The utilization of a bismuth-substituted iron garnet as a magnetooptic Faraday rotator (MOFR) has been reported for all-optical networking purposes as well as for other applications. Our measurements and observations demonstrate that the MOFR saturates once a significantly large magnetic field (\u3e225 G) is applied. After the applied magnetic field enters the saturation region, the material\u27s magnetic domains can become pinned at intermediate levels of magnetization. Pinning in this form has not been reported nor well studied for this application. In this paper, a method to detect and describe anomalous pinning in terms of Faraday rotation is presented. Measurements on the changes in the state of polarization that a pinned material produces are examined. This paper will also present practical methods for unpinning the MOFR material, which are traditionally considered to be challenging

Synthetic Aperture Focusing Technique Using the Envelope Function for Ultrasonic Imaging

In traditional ultrasonic imaging systems, a transducer is scanned across the surface of a specimen at constant intervals. Synthetic aperture focusing techniques (SAFT) have been utilized extensively to process the RF data in order to enhance the signal-to-noise ratio of the image [1]. However, the implementation of the algorithm using sampled RF data has the disadvantage of requiring large memory and high-speed devices. These requirements can be reduced by using the envelope of the RF signal which involves processing the baseband signal. The envelope detection can be easily implemented as part of the receiver circuit