485 research outputs found
Role of glutathionylation in infection and inflammation
Glutathionylation, that is, the formation of mixed disulfides between protein cysteines and
glutathione (GSH) cysteines, is a reversible post-translational modification catalyzed by dierent
cellular oxidoreductases, by which the redox state of the cell modulates protein function. So far, most
studies on the identification of glutathionylated proteins have focused on cellular proteins, including
proteins involved in host response to infection, but there is a growing number of reports showing
that microbial proteins also undergo glutathionylation, with modification of their characteristics and
functions. In the present review, we highlight the signaling role of GSH through glutathionylation,
particularly focusing on microbial (viral and bacterial) glutathionylated proteins (GSSPs) and host
GSSPs involved in the immune/inflammatory response to infection; moreover, we discuss the
biological role of the process in microbial infections and related host responses
The formation and evolution of early-type galaxies : solid results and open questions
The most recent results and some of the open key questions on the evolution
of early-type galaxies are reviewed in the general cosmological context of
massive galaxy formation.Comment: 8 pages, invited review at the workshop "Probing Stellar Populations
out to the Distant Universe", Cefalu` (Italy), September 7 - 19, 200
Spectral libraries and their uncertainties
Libraries of stellar spectra are fundamental tools in the study of stellar
populations and in automatic determination of atmospheric parameters for large
samples of observed stars. In the context of the present volume, here I give an
overview of the current status of stellar spectral libraries from the
perspective of stellar population modeling: what we have currently available,
how good they are, and where we need further improvement
Early metal enrichment in high-redshift quasars
Quasars are powerful systems whose spectrum is rich of metal features that
allow us to investigate the chemical evolution of galaxies at very high
redshift, even close to the reionization epoch. I review the main observational
constraints on the metallicity of quasars host galaxies at high redshift and
discuss the implications and issues for models of galaxy evolution in the early
universe.Comment: 8 pages, invited review at the workshop "Probing Stellar Populations
out to the Distant Universe
Advances on GRB as cosmological tools
Several interesting correlations among Gamma Ray Bursts (GRB) prompt and
afterglow properties have been found in the recent years. Some of these
correlations have been proposed also to standardize GRB energetics to use them
as standard candles in constraining the expansion history of the universe up to
z>6. However, given the still unexplained nature of most of these correlations,
only the less scattered correlations can be used for constraining the
cosmological parameters. The updated E_peak-E_gamma correlation is presented.
Caveats of alternative methods of standardizing GRB energetics are discussed.Comment: 8 parges, AIP conf. proc. "Probing stellar populations out to the
distant universe, Cefalu' 2008" Vol. 1111, pp. 579-58
Unsolved Problems about Supernovae
A number of unsolved problems and open questions about the nature and the
properties of supernovae are identified and briefly discussed. Some suggestions
and directions toward possible solutions are also considered.Comment: 7 pages, Proceedings of 'Probing Stellar Populations out to the
Distant Universe', Cefalu, Italy, Sep 7-19, 2008, AIP Conf. Proc. Serie
On the Origin of the Early Solar System Radioactivities. Problems with the AGB and Massive Star Scenarios
Recent improvements in stellar models for intermediate-mass and massive stars
are recalled, together with their expectations for the synthesis of radioactive
nuclei of lifetime Myr, in order to re-examine the origins
of now extinct radioactivities, which were alive in the solar nebula. The
Galactic inheritance broadly explains most of them, especially if -process
nuclei are produced by neutron star merging according to recent models.
Instead, Al, Ca, Cs and possibly Fe require
nucleosynthesis events close to the solar formation. We outline the persisting
difficulties to account for these nuclei by Intermediate Mass Stars (2
M/M). Models of their final stages now
predict the ubiquitous formation of a C reservoir as a neutron capture
source; hence, even in presence of Al production from Deep Mixing or Hot
Bottom Burning, the ratio Al/Pd remains incompatible with
measured data, with a large excess in Pd. This is shown for two recent
approaches to Deep Mixing. Even a late contamination by a Massive Star meets
problems. In fact, inhomogeneous addition of Supernova debris predicts
non-measured excesses on stable isotopes. Revisions invoking specific low-mass
supernovae and/or the sequential contamination of the pre-solar molecular cloud
might be affected by similar problems, although our conclusions here are
weakened by our schematic approach to the addition of SN ejecta. The limited
parameter space remaining to be explored for solving this puzzle is discussed.Comment: Accepted for publication on Ap
The cannonball model of long GRBs - overview
During the past ten years, the predictions of the cannonball (CB) model of
gamma ray bursts (GRBs) were repeatedly confronted with the mounting data from
space- and ground-based observations of GRBs and their afterglows (AGs). The
two underlying radiation mechanisms of the model, inverse Compton scattering
(ICS) and synchrotron radiation (SR), provided an accurate description of the
prompt and afterglow emission in all of the many well-sampled GRBs that were
studied. Simple as they are, these two mechanisms and the burst environment
were shown to generate the observed rich structure of the GRB light-curves at
all observed frequencies and times.Comment: Invited talk, to be published in the proceedings of Cefalu 2009
workshop `Probing stellar populations out to the distant universe', Cefalu,
Sicily, Italy, September 7-19, 200
New Stationary Frame Control Scheme for Three Phase PWM Rectifiers Under Unbalanced Voltage Dips Conditions
A new stationary frame control scheme for three-phase pulsewidth-modulation (PWM) rectifiers operating under unbalanced voltage dips conditions is proposed in this paper. The proposed control scheme regulates the instantaneous active power at the converter poles to minimize the harmonics of the input currents and the output voltage ripple. This paper's novelty is the development of a new current-reference generator implemented directly in stationary reference frame. This allows using proportional sinusoidal signal integrator (P-SSI) controllers for simultaneous compensation of both positive and negative current sequence components. No phase-locked loop (PLL) strategies and coordinate transformations are needed for the proposed current-reference generator. Experimental results are presented for a 20-kV A alternative current (ac)/direct current (dc) converter prototype to demonstrate the effectiveness of the proposed control scheme. A comparison with two other existing control techniques is also performed. Fast dynamic performance with small dc-link voltage ripple and input sinusoidal currents are obtained with this control scheme, even under severe voltage dips operating conditions
Disentangling age and metallicity in distant unresolved stellar systems
We present some results of an observational and theoretical study on
unresolved stellar systems based on the Surface Brightness Fluctuations (SBF)
technique. It is shown that SBF magnitudes are a valuable tracer of stellar
population properties, and a reliable distance indicator. SBF magnitudes,
SBF-colors, and SBF-gradients can help to constrain within relatively narrow
limits the metallicity and age of the dominant stellar component in distant
stellar systems, especially if coupled with other spectro-photometric
indicators.Comment: A contributed paper to the Cefalu' (Italy) "Probing Stellar
Populations out to the Distant Universe", 4 pages. To appear as an AIP
Conference Proceedin
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