Role of glutathionylation in infection and inflammation

Glutathionylation, that is, the formation of mixed disulfides between protein cysteines and glutathione (GSH) cysteines, is a reversible post-translational modification catalyzed by dierent cellular oxidoreductases, by which the redox state of the cell modulates protein function. So far, most studies on the identification of glutathionylated proteins have focused on cellular proteins, including proteins involved in host response to infection, but there is a growing number of reports showing that microbial proteins also undergo glutathionylation, with modification of their characteristics and functions. In the present review, we highlight the signaling role of GSH through glutathionylation, particularly focusing on microbial (viral and bacterial) glutathionylated proteins (GSSPs) and host GSSPs involved in the immune/inflammatory response to infection; moreover, we discuss the biological role of the process in microbial infections and related host responses

The formation and evolution of early-type galaxies : solid results and open questions

The most recent results and some of the open key questions on the evolution of early-type galaxies are reviewed in the general cosmological context of massive galaxy formation.Comment: 8 pages, invited review at the workshop "Probing Stellar Populations out to the Distant Universe", Cefalu` (Italy), September 7 - 19, 200

Spectral libraries and their uncertainties

Libraries of stellar spectra are fundamental tools in the study of stellar populations and in automatic determination of atmospheric parameters for large samples of observed stars. In the context of the present volume, here I give an overview of the current status of stellar spectral libraries from the perspective of stellar population modeling: what we have currently available, how good they are, and where we need further improvement

Early metal enrichment in high-redshift quasars

Quasars are powerful systems whose spectrum is rich of metal features that allow us to investigate the chemical evolution of galaxies at very high redshift, even close to the reionization epoch. I review the main observational constraints on the metallicity of quasars host galaxies at high redshift and discuss the implications and issues for models of galaxy evolution in the early universe.Comment: 8 pages, invited review at the workshop "Probing Stellar Populations out to the Distant Universe

Advances on GRB as cosmological tools

Several interesting correlations among Gamma Ray Bursts (GRB) prompt and afterglow properties have been found in the recent years. Some of these correlations have been proposed also to standardize GRB energetics to use them as standard candles in constraining the expansion history of the universe up to z>6. However, given the still unexplained nature of most of these correlations, only the less scattered correlations can be used for constraining the cosmological parameters. The updated E_peak-E_gamma correlation is presented. Caveats of alternative methods of standardizing GRB energetics are discussed.Comment: 8 parges, AIP conf. proc. "Probing stellar populations out to the distant universe, Cefalu' 2008" Vol. 1111, pp. 579-58

Unsolved Problems about Supernovae

A number of unsolved problems and open questions about the nature and the properties of supernovae are identified and briefly discussed. Some suggestions and directions toward possible solutions are also considered.Comment: 7 pages, Proceedings of 'Probing Stellar Populations out to the Distant Universe', Cefalu, Italy, Sep 7-19, 2008, AIP Conf. Proc. Serie

On the Origin of the Early Solar System Radioactivities. Problems with the AGB and Massive Star Scenarios

Recent improvements in stellar models for intermediate-mass and massive stars are recalled, together with their expectations for the synthesis of radioactive nuclei of lifetime $\tau \lesssim 25$ Myr, in order to re-examine the origins of now extinct radioactivities, which were alive in the solar nebula. The Galactic inheritance broadly explains most of them, especially if $r$-process nuclei are produced by neutron star merging according to recent models. Instead, $^{26}$Al, $^{41}$Ca, $^{135}$Cs and possibly $^{60}$Fe require nucleosynthesis events close to the solar formation. We outline the persisting difficulties to account for these nuclei by Intermediate Mass Stars (2 $\lesssim$ M/M$_\odot \lesssim 7 - 8$). Models of their final stages now predict the ubiquitous formation of a $^{13}$C reservoir as a neutron capture source; hence, even in presence of $^{26}$Al production from Deep Mixing or Hot Bottom Burning, the ratio $^{26}$Al/$^{107}$Pd remains incompatible with measured data, with a large excess in $^{107}$Pd. This is shown for two recent approaches to Deep Mixing. Even a late contamination by a Massive Star meets problems. In fact, inhomogeneous addition of Supernova debris predicts non-measured excesses on stable isotopes. Revisions invoking specific low-mass supernovae and/or the sequential contamination of the pre-solar molecular cloud might be affected by similar problems, although our conclusions here are weakened by our schematic approach to the addition of SN ejecta. The limited parameter space remaining to be explored for solving this puzzle is discussed.Comment: Accepted for publication on Ap

The cannonball model of long GRBs - overview

During the past ten years, the predictions of the cannonball (CB) model of gamma ray bursts (GRBs) were repeatedly confronted with the mounting data from space- and ground-based observations of GRBs and their afterglows (AGs). The two underlying radiation mechanisms of the model, inverse Compton scattering (ICS) and synchrotron radiation (SR), provided an accurate description of the prompt and afterglow emission in all of the many well-sampled GRBs that were studied. Simple as they are, these two mechanisms and the burst environment were shown to generate the observed rich structure of the GRB light-curves at all observed frequencies and times.Comment: Invited talk, to be published in the proceedings of Cefalu 2009 workshop `Probing stellar populations out to the distant universe', Cefalu, Sicily, Italy, September 7-19, 200

New Stationary Frame Control Scheme for Three Phase PWM Rectifiers Under Unbalanced Voltage Dips Conditions

A new stationary frame control scheme for three-phase pulsewidth-modulation (PWM) rectifiers operating under unbalanced voltage dips conditions is proposed in this paper. The proposed control scheme regulates the instantaneous active power at the converter poles to minimize the harmonics of the input currents and the output voltage ripple. This paper's novelty is the development of a new current-reference generator implemented directly in stationary reference frame. This allows using proportional sinusoidal signal integrator (P-SSI) controllers for simultaneous compensation of both positive and negative current sequence components. No phase-locked loop (PLL) strategies and coordinate transformations are needed for the proposed current-reference generator. Experimental results are presented for a 20-kV A alternative current (ac)/direct current (dc) converter prototype to demonstrate the effectiveness of the proposed control scheme. A comparison with two other existing control techniques is also performed. Fast dynamic performance with small dc-link voltage ripple and input sinusoidal currents are obtained with this control scheme, even under severe voltage dips operating conditions

Disentangling age and metallicity in distant unresolved stellar systems

We present some results of an observational and theoretical study on unresolved stellar systems based on the Surface Brightness Fluctuations (SBF) technique. It is shown that SBF magnitudes are a valuable tracer of stellar population properties, and a reliable distance indicator. SBF magnitudes, SBF-colors, and SBF-gradients can help to constrain within relatively narrow limits the metallicity and age of the dominant stellar component in distant stellar systems, especially if coupled with other spectro-photometric indicators.Comment: A contributed paper to the Cefalu' (Italy) "Probing Stellar Populations out to the Distant Universe", 4 pages. To appear as an AIP Conference Proceedin