69 research outputs found

    Rabindranath Tagore's Syncretistic Philosophy and the Persian Sufi Tradition

    Get PDF
    This is the author accepted manuscript. The final published electronic version is available at the web site of JSTOR via the link in his record.Rabindranath Tagore (1861–1941) has been praised by a number of Bengali Muslim authors for his sympathetic portrayal of Islamic concepts and ideals, and it is well known that some of his works of prose and verse were influenced by Persian poetry and Sufism. Tagore’s father knew Persian and could recite the poetry of Ḥāfiẓ (d. 1389) by heart. Tagore himself was also deeply influenced by the Persian classical poet. In the last decade of his life, Tagore described his admiration for the great Persian Sufi poets, visiting the tombs of Ḥāfiẓ and Sa‘dī in Shiraz. In this article, I will discuss the spiritual milieu of the Persianate culture of nineteenthand early twentieth-century Bengal to shed light on the extent of the influence of Persian Sufi ideas on this milieu in general and Tagore in particular. Attention will also be given to other aspects of Tagore’s religious syncretism: Bāul mysticism and its lyric poetry, Sahaja Buddhism, Vedanta philosophy, the Upanishads, and a few other currents of Eastern thought. Lastly, I will explore Tagore’s relationship with Persian Sufi concepts and poetry and discuss the effect of his visit to Iran and his encounter with the poet Ḥāfi

    Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report

    Get PDF
    <p>Abstract</p> <p>Introduction</p> <p>This is the first report of possible direct stimulation of hormone-resistant prostate cancer or interference of docetaxel cytotoxicity of prostate cancer in a patient with biochemical relapse of prostatic-specific antigen. This observation is of clinical and metabolic importance, especially at a time when more than 80 countries have fortified food supplies with folic acid and some contemplate further fortification with vitamin B<sub>12</sub>.</p> <p>Case presentation</p> <p>Our patient is a 71-year-old Caucasian man who had been diagnosed in 1997 with prostate cancer, stage T1c, and Gleason score 3+4 = 7. His primary treatment included intermittent androgen deprivation therapy including leuprolide + bicalutamide + deutasteride, ketoconazole + hydrocortisone, nilandrone and flutamide to resistance defined as biochemical relapse of PSA. While undergoing docetaxel therapy to treat a continually increasing prostate-specific antigen level, withdrawal of 10 daily doses of a supplement containing 500 μg of vitamin B<sub>12 </sub>as cyanocobalamin, as well as 400 μg of folic acid as pteroylglutamic acid and 400 μg of L-5-methyltetrahydrofolate for a combined total of 800 μg of mixed folates, was associated with a return to a normal serum prostatic-specific antigen level.</p> <p>Conclusion</p> <p>This case report illustrates the importance of the effects of supplements containing large amounts of folic acid, L-5-methyltetrahydrofolate, and cyanocobalamin on the metabolism of prostate cancer cells directly and/or B vitamin interference with docetaxel efficacy. Physicians caring for patients with prostate cancer undergoing watchful waiting, hormone therapy, and/or chemotherapy should consider the possible acceleration of tumor growth and/or metastasis and the development of drug resistance associated with supplement ingestion. We describe several pathways of metabolic and epigenetic interactions that could affect the observed changes in serum levels of prostate-specific antigen.</p
    corecore