9 research outputs found
Recommandations pour lâoxygĂ©nothĂ©rapie chez lâenfant en situations aiguĂ«s et chroniques : Ă©valuation du besoin, critĂšres de mise en route, modalitĂ©s de prescription et de surveillance
International audienceRecommendations for acute and long-term oxygen therapy (needs assessment, implementation criteria, prescription practices, and follow-up) in children were produced by the Groupe de Recherche sur les AvancĂ©es en Pneumo-PĂ©diatrie (GRAPP) under the auspices of the French Paediatric Pulmonology and Allergology Society (SP2A). The Haute AutoritĂ© de SantĂ© (HAS) methodology, based on the Formalized Consensus, was used. A first panel of experts analyzed the English and French literature to provide a second panel of experts with recommendations to validate. Only the recommendations are presented here, but the full text (arguments + recommendations) is available at the website of the French Paediatric Society: www.sfpediatrie.com.Le Groupe de recherche sur les avancĂ©es en pneumo-pĂ©diatrie (GRAPP) a Ă©laborĂ© en 2010 sous lâĂ©gide de la SociĂ©tĂ© pĂ©diatrique de pneumologie et dâallergologie (SP2A) des recommandations sur lâĂ©valuation du besoin, les critĂšres de mise en route, les modalitĂ©s de prescription et de surveillance de lâoxygĂ©nothĂ©rapie chez lâenfant, en situations aiguĂ«s et chroniques. Ces recommandations ont Ă©tĂ© rĂ©alisĂ©es selon les modalitĂ©s du consensus formalisĂ© de la Haute AutoritĂ© de santĂ© (HAS) Ă partir dâune lecture, par un groupe dâexperts, de la bibliographie en langue anglaise et française. Les recommandations ont ensuite Ă©tĂ© validĂ©es par un second groupe dâexperts. Seules les recommandations sont prĂ©sentĂ©es dans ce texte court, la totalitĂ© du texte (argumentaire + recommandations) est accessible sur le site de la SociĂ©tĂ© française de pĂ©diatrie : www.sfpediatrie.com
Recommandations pour lâoxygĂ©nothĂ©rapie chez lâenfant en situations aiguĂ«s et chroniques : Ă©valuation du besoin, critĂšres de mise en route, modalitĂ©s de prescription et de surveillance
International audienceRecommendations for acute and long-term oxygen therapy (needs assessment, implementation criteria, prescription practices, and follow-up) in children were produced by the Groupe de Recherche sur les AvancĂ©es en Pneumo-PĂ©diatrie (GRAPP) under the auspices of the French Paediatric Pulmonology and Allergology Society (SP2A). The Haute AutoritĂ© de SantĂ© (HAS) methodology, based on the Formalized Consensus, was used. A first panel of experts analyzed the English and French literature to provide a second panel of experts with recommendations to validate. Only the recommendations are presented here, but the full text (arguments + recommendations) is available at the website of the French Paediatric Society: www.sfpediatrie.com.Le Groupe de recherche sur les avancĂ©es en pneumo-pĂ©diatrie (GRAPP) a Ă©laborĂ© en 2010 sous lâĂ©gide de la SociĂ©tĂ© pĂ©diatrique de pneumologie et dâallergologie (SP2A) des recommandations sur lâĂ©valuation du besoin, les critĂšres de mise en route, les modalitĂ©s de prescription et de surveillance de lâoxygĂ©nothĂ©rapie chez lâenfant, en situations aiguĂ«s et chroniques. Ces recommandations ont Ă©tĂ© rĂ©alisĂ©es selon les modalitĂ©s du consensus formalisĂ© de la Haute AutoritĂ© de santĂ© (HAS) Ă partir dâune lecture, par un groupe dâexperts, de la bibliographie en langue anglaise et française. Les recommandations ont ensuite Ă©tĂ© validĂ©es par un second groupe dâexperts. Seules les recommandations sont prĂ©sentĂ©es dans ce texte court, la totalitĂ© du texte (argumentaire + recommandations) est accessible sur le site de la SociĂ©tĂ© française de pĂ©diatrie : www.sfpediatrie.com
Humanização do atendimento em saĂșde: conhecimento veiculado na literatura brasileira de enfermagem
A protein engineered to bind uranyl selectively and with femtomolar affinity
Uranyl (UO22+), the predominant aerobic form of uranium, is present in the ocean at a concentration of similar to 3.2 parts per 10(9) (13.7 nM); however, the successful enrichment of uranyl from this vast resource has been limited by the high concentrations of metal ions of similar size and charge, which makes it difficult to design a binding motif that is selective for uranyl. Here we report the design and rational development of a uranyl-binding protein using a computational screening process in the initial search for potential uranyl-binding sites. The engineered protein is thermally stable and offers very high affinity and selectivity for uranyl with a K-d of 7.4 femtomolar (fM) and >10,000-fold selectivity over other metal ions. We also demonstrated that the uranyl-binding protein can repeatedly sequester 30-60% of the uranyl in synthetic sea water. The chemical strategy employed here may be applied to engineer other selective metal-binding proteins for biotechnology and remediation applications.Chemistry, MultidisciplinarySCI(E)[email protected]; [email protected]