28,562 research outputs found
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Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles.
Acid-degradable cationic nanoparticles encapsulating a model antigen (i.e., ovalbumin) were prepared by inverse microemulsion polymerization with acid-cleavable acetal cross-linkers. Incubation of these degradable nanoparticles with dendritic cells derived from bone marrow (BMDCs) resulted in the enhanced presentation of ovalbumin-derived peptides, as quantified by B3Z cells, a CD8+ T cell hybridoma. The cationic nature of the particles contributed to the increased surface endocytosis (or phagocytosis) observed with BMDCs, which is the first barrier to overcome for successful antigen delivery. The acid sensitivity of the particles served to direct more ovalbumin antigens to be processed into the appropriately trimmed peptide fragments and presented via the major histocompatibility complex (MHC) class I pathway following hydrolysis within the acidic lysosomes. It was also shown that adjuvant molecules such as unmethylated CpG oligonucleotides (CpG ODN) and anti-interleukin-10 oligonucleotides (AS10 ODN) could be co-delivered with the protein antigen for maximized cellular immune response
Orientational Melting in Carbon Nanotube Ropes
Using Monte Carlo simulations, we investigate the possibility of an
orientational melting transition within a "rope" of (10,10) carbon nanotubes.
When twisting nanotubes bundle up during the synthesis, orientational
dislocations or twistons arise from the competition between the anisotropic
inter-tube interactions, which tend to align neighboring tubes, and the torsion
rigidity that tends to keep individual tubes straight. We map the energetics of
a rope containing twistons onto a lattice gas model and find that the onset of
a free "diffusion" of twistons, corresponding to orientational melting, occurs
at T_OM > 160 K.Comment: 4 page LaTeX file with 3 figures (10 PostScript files
EVALUATING A PRECISION AGRICULTURE HERBICIDE DECISION MODEL FOR WINTER WHEAT
Replaced with revised version of paper 08/02.Crop Production/Industries,
Structure And Properties of Nanoparticles Formed under Conditions of Wire Electrical Explosion
Structure and properties of nanoparticles formed under conditions of wire
electrical explosion were studied. It was shown that the state of WEE power
particles can be characterized as a metastable state. It leads to an increased
stability of nanopowders at normal temperatures and an increased reactivity
during heating, which is revealed in the form of threshold phenomena.Comment: Submitted on behalf of TIMA Editions
(http://irevues.inist.fr/tima-editions
Simulation of iced wing aerodynamics
The sectional and total aerodynamic load characteristics of moderate aspect ratio wings with and without simulated glaze leading edge ice were studied both computationally, using a three dimensional, compressible Navier-Stokes solver, and experimentally. The wing has an untwisted, untapered planform shape with NACA 0012 airfoil section. The wing has an unswept and swept configuration with aspect ratios of 4.06 and 5.0. Comparisons of computed surface pressures and sectional loads with experimental data for identical configurations are given. The abrupt decrease in stall angle of attack for the wing, as a result of the leading edge ice formation, was demonstrated numerically and experimentally
Electronic structures of doped anatase : (M=Co, Mn, Fe, Ni)
We have investigated electronic structures of a room temperature diluted
magnetic semiconductor : Co-doped anatase . We have obtained the
half-metallic ground state in the local-spin-density approximation(LSDA) but
the insulating ground state in the LSDA++SO incorporating the spin-orbit
interaction. In the stoichiometric case, the low spin state of Co is realized
with the substantially large orbital moment. However, in the presence of oxygen
vacancies near Co, the spin state of Co becomes intermediate. The
ferromagnetisms in the metallic and insulating phases are accounted for by the
double-exchange-like and the superexchange mechanism, respectively. Further,
the magnetic ground states are obtained for Mn and Fe doped ,
while the paramagnetic ground state for Ni-doped .Comment: 5 pages, 4 figure
Who Contributes to the Knowledge Sharing Economy?
Information sharing dynamics of social networks rely on a small set of
influencers to effectively reach a large audience. Our recent results and
observations demonstrate that the shape and identity of this elite, especially
those contributing \emph{original} content, is difficult to predict.
Information acquisition is often cited as an example of a public good. However,
this emerging and powerful theory has yet to provably offer qualitative
insights on how specialization of users into active and passive participants
occurs.
This paper bridges, for the first time, the theory of public goods and the
analysis of diffusion in social media. We introduce a non-linear model of
\emph{perishable} public goods, leveraging new observations about sharing of
media sources. The primary contribution of this work is to show that
\emph{shelf time}, which characterizes the rate at which content get renewed,
is a critical factor in audience participation. Our model proves a fundamental
\emph{dichotomy} in information diffusion: While short-lived content has simple
and predictable diffusion, long-lived content has complex specialization. This
occurs even when all information seekers are \emph{ex ante} identical and could
be a contributing factor to the difficulty of predicting social network
participation and evolution.Comment: 15 pages in ACM Conference on Online Social Networks 201
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“See, Click, Fix”: Civic Interrogation and Digital Tools in a Ninth-Grade Ethnic Studies Course
Drawing from the theoretical contributions of Ethnic Studies, activist new media, and critical digital literacies, this article explores the nature of a ninth-grade curricular unit about how one’s daily environment impacts one’s health and well-being. Using a combination of ethnographic and practitioner inquiry methods, the authors highlight an Ethnic Studies teacher’s innovative and community-based pedagogy that honed students’ critical digital literacies and civic action practices through their engagement with the digital media app “See, Click, Fix.” Findings detail students’ perspectives about how the unit both helped them resist deficit-oriented ideologies and served as a conduit for critical civic literacies. The authors contend that the fostering of critical digital literacies remain extremely imperative to the future and expansion of Ethnic Studies courses
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