6 research outputs found
Alkenes as Azido Precursors for the One-Pot Synthesis of 1,2,3-Triazoles Catalyzed by Copper Nanoparticles on Activated Carbon
A one-pot protocol for the synthesis of 1,2,3-triazoles has been developed starting from inactivated alkenes and based on two click reactions: the azidosulfenylation of the carbonâcarbon double bond and the copper-catalyzed azideâalkyne cycloaddition (CuAAC). High yields of the ÎČ-methylsulfanyl triazoles have been attained using CuNPs/C as catalyst, with other commercial copper catalysts being completely inactive. The versatility of the methylsulfanyl group has been demonstrated through a series of synthetic transformations, including direct access to 1-vinyl and 4-monosubstituted triazoles.Spanish Ministerio de EconomĂa y Competitividad (MINECO; CTQ2007-65218, CTQ2011-24151 and Consolider Ingenio 2010-CSD2007-00006), the Generalitat Valenciana (GV; PROMETEO/2009/039), and Fondo Europeo de Desarrollo Regional (FEDER)
Research data supporting: Iterative reactions of transient boronic acids enable sequential C-C bond formation
NMR filesThis record supports 'Iterative reactions of transient boronic acids enable sequential C-C bond formation', which has been published in Nature Chemistry.This work was supported by the EPSRC [grant numbers EP/K009494/1 and EP/M004120/1]
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
The coupling of aromatic moieties with saturated
heterocyclic partners is currently an area of significant interest for the pharmaceutical industry. Herein, we present a procedure for the metal-free coupling of 4-, 5-, and 6-membered saturated heterocyclic p-methoxyphenyl (PMP) sulfonylhydrazones with aryl and heteroaromatic boronic acids. This procedure enables a simple, two-step
synthesis of a range of functionalized sp2âsp3 linked bicyclic building blocks, including oxetanes, piperidines, and azetidines, from their parent ketones.
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