391 research outputs found
Ultrasound-Guided Peripheral Nerve Block Anesthesia with Emphasis on the Interscalene Approach to Brachial Plexus Blockade
Pemphigus Vulgaris and Skin Grafting**From the Tel Hashomer Government Hospital, Israel. (Chief, Dermatological Department. Assistant Dermatological Department. Chief, Plastic Surgery Department.)
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Magnetic divertor design for the compact reversed-field pinch reactor
A recently completed design of a pumped-limiter-based Compact Reversed-Field Pinch Reactor is used to estimate for the first time the impact of magnetic divertors. A range of divertor options for the low-toroidal-field RFP is examined, and a design selection is made constrained by consideration of field ripple (magnetic island), blanket displacement, recirculating power, cost, heat flux, and access. Design choices based on diversion of minority (toroidal) field lead to a preference for (poloidally) symmetric or bundle divertor geometries
Invariant higher-order variational problems II
Motivated by applications in computational anatomy, we consider a
second-order problem in the calculus of variations on object manifolds that are
acted upon by Lie groups of smooth invertible transformations. This problem
leads to solution curves known as Riemannian cubics on object manifolds that
are endowed with normal metrics. The prime examples of such object manifolds
are the symmetric spaces. We characterize the class of cubics on object
manifolds that can be lifted horizontally to cubics on the group of
transformations. Conversely, we show that certain types of non-horizontal
geodesics on the group of transformations project to cubics. Finally, we apply
second-order Lagrange--Poincar\'e reduction to the problem of Riemannian cubics
on the group of transformations. This leads to a reduced form of the equations
that reveals the obstruction for the projection of a cubic on a transformation
group to again be a cubic on its object manifold.Comment: 40 pages, 1 figure. First version -- comments welcome
Two-state passive mode-locking of quantum dot semiconductor lasers: Classical state scenario and novel reverse state dynamics
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Reverse-emission-state-transition mode locking of a two-section InAs/InGaAs quantum dot laser
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Simulation and Analysis of Dynamic Regimes Involving Ground and Excited State Transitions in Quantum Dot Passively Mode-Locked Lasers
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Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: A pivotal interplay in the pathogenesis of Atopic Dermatitis
Individuals with Atopic dermatitis (AD) are highly susceptible to Staphylococcus aureus colonization. However, the mechanisms driving this process as well as the impact of S. aureus in AD pathogenesis are still incompletely understood. In this study, we analysed the role of biofilm in sustaining S. aureus chronic persistence and its impact on AD severity. Further we explored whether key inflammatory cytokines overexpressed in AD might provide a selective advantage to S. aureus. Results show that the strength of biofilm production by S. aureus correlated with the severity of the skin lesion, being significantly higher (P < 0.01) in patients with a more severe form of the disease as compared to those individuals with mild AD. Additionally, interleukin (IL)-β and interferon γ (IFN-γ), but not interleukin (IL)-6, induced a concentration-dependent increase of S. aureus growth. This effect was not observed with coagulase-negative staphylococci isolated from the skin of AD patients. These findings indicate that inflammatory cytokines such as IL1-β and IFN-γ, can selectively promote S. aureus outgrowth, thus subverting the composition of the healthy skin microbiome. Moreover, biofilm production by S. aureus plays a relevant role in further supporting chronic colonization and disease severity, while providing an increased tolerance to antimicrobials
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