404 research outputs found
Superweakly interacting dark matter from the Minimal Walking Technicolor
We study a superweakly interacting dark matter particle motivated by minimal
walking technicolor theories. Our WIMP is a mixture of a sterile state and a
state with the charges of a standard model fourth family neutrino. We show that
the model can give the right amount of dark matter over a range of the WIMP
mass and mixing angle. We compute bounds on the model parameters from the
current accelerator data including the oblique corrections to the precision
electroweak parameters, as well as from cryogenic experiments, Super-Kamiokande
and from the IceCube experiment. We show that consistent dark matter solutions
exist which satisfy all current constraints. However, almost the entire
parameter range of the model lies within the the combined reach of the next
generation experiments.Comment: 29 pages, 6 figure
Dexamethasone in head and neck cancer patients with microvascular reconstruction : No benefit, more complications
Objectives: Glucocorticoids are widely used in association with major surgery of the head and neck to improve postoperative rehabilitation, shorten intensive care unit and hospital stay, and reduce neck swelling. This study aimed to clarify whether peri-and postoperative use of dexamethasone in reconstructive head and neck cancer surgery is associated with any advantages or disadvantages. Materials and methods: This prospective double-blind randomized controlled trial comprised 93 patients. A total dose of 60 mg of dexamethasone was administered to 51 patients over three days peri-and post-operatively. The remaining 42 patients served as controls. The main primary outcome variables were neck swelling, length of intensive care unit and hospital stay, duration of intubation or tracheostomy, and delay to start of possible radiotherapy. Complications were also recorded. Results: No statistical differences emerged between the two groups in any of the main primary outcome variables. However, there were more major complications, especially infections, needing secondary surgery within three weeks of the operation in patients receiving dexamethasone than in control patients (27% vs. 7%, p = 0.012). Conclusions: The use of dexamethasone in oral cancer patients with microvascular reconstruction did not provide a benefit. More major complications, especially infections, occurred in patients receiving dexamethasone. Our data thus do not support the use of peri-and postoperative dexamethasone in oropharyngeal cancer patients undergoing microvascular reconstruction. (C) 2016 Elsevier Ltd. All rights reserved.Peer reviewe
Do Lognormal Column-Density Distributions in Molecular Clouds Imply Supersonic Turbulence?
Recent observations of column densities in molecular clouds find lognormal
distributions with power-law high-density tails. These results are often
interpreted as indications that supersonic turbulence dominates the dynamics of
the observed clouds. We calculate and present the column-density distributions
of three clouds, modeled with very different techniques, none of which is
dominated by supersonic turbulence. The first star-forming cloud is simulated
using smoothed particle hydrodynamics (SPH); in this case gravity, opposed only
by thermal-pressure forces, drives the evolution. The second cloud is
magnetically subcritical with subsonic turbulence, simulated using nonideal
MHD; in this case the evolution is due to gravitationally-driven ambipolar
diffusion. The third cloud is isothermal, self-gravitating, and has a smooth
density distribution analytically approximated with a uniform inner region and
an r^-2 profile at larger radii. We show that in all three cases the
column-density distributions are lognormal. Power-law tails develop only at
late times (or, in the case of the smooth analytic profile, for strongly
centrally concentrated configurations), when gravity dominates all opposing
forces. It therefore follows that lognormal column-density distributions are
generic features of diverse model clouds, and should not be interpreted as
being a consequence of supersonic turbulence.Comment: 6 pages, 6 figures, accepted for publication in MNRA
Oscillation Induced Neutrino Asymmetry Growth in the Early Universe
We study the dynamics of active-sterile neutrino oscillations in the early
universe using full momentum-dependent quantum-kinetic equations. These
equations are too complicated to allow for an analytical treatment, and
numerical solution is greatly complicated due to very pronounced and narrow
structures in the momentum variable introduced by resonances. Here we introduce
a novel dynamical discretization of the momentum variable which overcomes this
problem. As a result we can follow the evolution of neutrino ensemble
accurately well into the stable growing phase. Our results confirm the
existence of a "chaotic region" of mixing parameters, for which the final sign
of the asymmetry, and hence the SBBN prediction of He(4)-abundance cannot be
accurately determined.Comment: 23 pages, 9 eps-figs, Latex, uses JHEP clas
Flavour-coherent propagators and Feynman rules: Covariant cQPA formulation
We present a simplified and generalized derivation of the flavour-coherent
propagators and Feynman rules for the fermionic kinetic theory based on
coherent quasiparticle approximation (cQPA). The new formulation immediately
reveals the composite nature of the cQPA Wightman function as a product of two
spectral functions and an effective two-point interaction vertex, which
contains all quantum statistical and coherence information. We extend our
previous work to the case of nonzero dispersive self-energy, which leads to a
broader range of applications. By this scheme, we derive flavoured kinetic
equations for local 2-point functions , which are
reminiscent of the equations of motion for the density matrix. We emphasize
that in our approach all the interaction terms are derived from first
principles of nonequilibrium quantum field theory.Comment: 20 pages, 3 figures. Minor modifications, version published in JHE
Detailed study of BBN implications of neutrino oscillation generated neutrino asymmetries in some four neutrino models
We re-examine the evolution of neutrino asymmetries in several four neutrino
models. The first case involves the direct creation of by oscillations. In the second case, we consider the mass
hierarchy where oscillations generate a large and some of
this asymmetry is converted into by oscillations. We estimate the implications for BBN for a range of
cosmologically interesting values. The present paper improves on
previous published work by taking into account the finite repopulation rate and
the time dependence of the distortions to the neutrino momentum distributions.
The treatment of chemical decoupling is also improved.Comment: Expanded discussion on the sign of the neutrino asymmetr
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus
Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A corepressor complex recruits histone deacetylases and in many cases represses transcription. Here, we report that SAP30L, a close homolog of Sin3-associated protein 30 (SAP30), interacts with several components of the Sin3A corepressor complex. We show that it binds to the PAH3/HID (Paired Amphipathic Helix 3/Histone deacetylase Interacting Domain) region of mouse Sin3A with residues 120–140 in the C-terminal part of the protein. We provide evidence that SAP30L induces transcriptional repression, possibly via recruitment of Sin3A and histone deacetylases. Finally, we characterize a functional nucleolar localization signal in SAP30L and show that SAP30L and SAP30 are able to target Sin3A to the nucleolus
Particle Dark Matter Candidates
I give a short overview on some of the favorite particle Cold Dark Matter
candidates today, focusing on those having detectable interactions: the axion,
the KK-photon in Universal Extra Dimensions, the heavy photon in Little Higgs
and the neutralino in Supersymmetry. The neutralino is still the most popular,
and today is available in different flavours: SUGRA, nuSUGRA, sub-GUT, Mirage
mediation, NMSSM, effective MSSM, scenarios with CP violation. Some of these
scenarios are already at the level of present sensitivities for direct DM
searches.Comment: 7 pages, 4 figures, 3 references added. Contribution to the
proceedings of the TAUP 07 conference, Sep. 11-15, Sendai, Japa
Scales of the Extra Dimensions and their Gravitational Wave Backgrounds
Circumstances are described in which symmetry breaking during the formation
of our three-dimensional brane within a higher-dimensional space in the early
universe excites mesoscopic classical radion or brane-displacement degrees of
freedom and produces a detectable stochastic background of gravitational
radiation. The spectrum of the background is related to the unification energy
scale and the the sizes and numbers of large extra dimensions. It is shown that
properties of the background observable by gravitational-wave observatories at
frequencies Hz to Hz contain information about
unification on energy scales from 1 to TeV, gravity propagating
through extra-dimension sizes from 1 mm to mm, and the dynamical
history and stabilization of from one to seven extra dimensions.Comment: 6 pages, Latex, 1 figure, submitted to Phys. Re
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