1,143 research outputs found
The multifaceted role of astrocytes in regulating myelination
Astrocytes are the major glial cell of the central nervous system (CNS), providing both metabolic and physical support to other neural cells. After injury, astrocytes become reactive and express a continuum of phenotypes which may be supportive or inhibitory to CNS repair. This review will focus on the ability of astrocytes to influence myelination in the context of specific secreted factors, cytokines and other neural cell targets within the CNS. In particular, we focus on how astrocytes provide energy and cholesterol to neurons, influence synaptogenesis, affect oligodendrocyte biology and instigate cross-talk between the many cellular components of the CNS
Quantitative imaging of gas adsorption equilibrium and dynamics by X-ray Computed Tomography
We present the development and application of X-ray Computed Tomography (CT) for the determination of the adsorption properties of microporous adsorbents and the study of breakthrough experiments in a laboratory fixed-bed adsorption column. Using the model system CO2/helium on activated carbon, equilibrium and dynamic adsorption/desorption measurements by X-ray CT are described, and the results are successfully compared to those obtained from conventional methods, including the application of a one-dimensional dynamic column breakthrough model. The study demonstrates the practical feasibility of applying X-ray CT to measure internal and transient concentration profiles in adsorbent systems on the length-scales from a single adsorbent pellet to a packed column
Nebular-Phase Spectra of Nearby Type Ia Supernovae
We present late-time spectra of eight Type Ia supernovae (SNe Ia) obtained at
days after peak brightness using the Gemini South and Keck telescopes.
All of the SNe Ia in our sample were nearby, well separated from their host
galaxy's light, and have early-time photometry and spectroscopy from the Las
Cumbres Observatory (LCO). Parameters are derived from the light curves and
spectra such as peak brightness, decline rate, photospheric velocity, and the
widths and velocities of the forbidden nebular emission lines. We discuss the
physical interpretations of these parameters for the individual SNe Ia and the
sample in general, including comparisons to well-observed SNe Ia from the
literature. There are possible correlations between early-time and late-time
spectral features that may indicate an asymmetric explosion, so we discuss our
sample of SNe within the context of models for an offset ignition and/or white
dwarf collisions. A subset of our late-time spectra are uncontaminated by host
emission, and we statistically evaluate our nondetections of H emission
to limit the amount of hydrogen in these systems. Finally, we consider the
late-time evolution of the iron emission lines, finding that not all of our SNe
follow the established trend of a redward migration at days after
maximum brightness.Comment: 20 pages, 8 figures, 9 tables; accepted to MNRA
Using late-time optical and near-infrared spectra to constrain Type Ia supernova explosion properties
The late-time spectra of Type Ia supernovae (SNe Ia) are powerful probes of
the underlying physics of their explosions. We investigate the late-time
optical and near-infrared spectra of seven SNe Ia obtained at the VLT with
XShooter at 200 d after explosion. At these epochs, the inner Fe-rich ejecta
can be studied. We use a line-fitting analysis to determine the relative line
fluxes, velocity shifts, and line widths of prominent features contributing to
the spectra ([Fe II], [Ni II], and [Co III]). By focussing on [Fe II] and [Ni
II] emission lines in the ~7000-7500 \AA\ region of the spectrum, we find that
the ratio of stable [Ni II] to mainly radioactively-produced [Fe II] for most
SNe Ia in the sample is consistent with Chandrasekhar-mass delayed-detonation
explosion models, as well as sub-Chandrasekhar mass explosions that have
metallicity values above solar. The mean measured Ni/Fe abundance of our sample
is consistent with the solar value. The more highly ionised [Co III] emission
lines are found to be more centrally located in the ejecta and have broader
lines than the [Fe II] and [Ni II] features. Our analysis also strengthens
previous results that SNe Ia with higher Si II velocities at maximum light
preferentially display blueshifted [Fe II] 7155 \AA\ lines at late times. Our
combined results lead us to speculate that the majority of normal SN Ia
explosions produce ejecta distributions that deviate significantly from
spherical symmetry.Comment: 17 pages, 12 figure, accepted for publication in MNRA
Surgery-Induced Weight Loss and Changes in Hormonally Active Fibroblast Growth Factors: a Systematic Review and Meta-Analysis
This systematic review and meta-analysis was performed to investigate the possible changes of FGF-19 and FGF-21 after bariatric surgery (BS). Electronic databases including PubMed and Scopus were systematically searched up to February 2020 to identify pertinent studies. A total of 25 different studies were included. The overall pooled analysis identified that BS caused a significant increase in FGF-19, but had no significant effect on FGF-21. For FGF-19, this finding was supported in the subgroup analyses. For FGF-21, Roux-en-Y gastric bypass (RYGB) surgery significantly increased FGF-21 levels, whereas, in studies with follow-up duration � 1 year, FGF-21 levels decreased significantly. BS reduces circulating concentration of FGF-19, but might increase FGF-21 after RYGB or decrease FGF-21 after � 1 year. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
SN 2015ba: A type IIP supernova with a long plateau
We present optical photometry and spectroscopy from about a week after
explosion to 272 d of an atypical Type IIP supernova, SN 2015ba, which
exploded in the edge-on galaxy IC 1029. SN 2015ba is a luminous event with an
absolute V-band magnitude of -17.10.2 mag at 50 d since explosion and has
a long plateau lasting for 123 d. The distance to the SN is estimated to
be 34.80.7 Mpc using the expanding photosphere and standard candle
methods. High-velocity H-Balmer components constant with time are observed in
the late-plateau phase spectra of SN 2015ba, which suggests a possible role of
circumstellar interaction at these phases. Both hydrodynamical and analytical
modelling suggest a massive progenitor of SN 2015ba with a pre-explosion mass
of 24-26 M. However, the nebular spectra of SN 2015ba exhibit
insignificant levels of oxygen, which is otherwise expected from a massive
progenitor. This might be suggestive of the non-monotonical link between O-core
masses and the zero-age main-sequence mass of pre-supernova stars and/or
uncertainties in the mixing scenario in the ejecta of supernovae.Comment: 42 pages, 7 pages Appendix, 20 figures, 10 tables, Accepted for
publication in MNRAS, 14-June-201
Evaluation of Errors Associated with Cutting-Induced Plasticity in Residual Stress Measurements Using the Contour Method
Cutting-induced plasticity can lead to elevated uncertainties in residual stress measurements made by the contour method. In this study plasticity-induced stress errors are numerically evaluated for a benchmark edge-welded beam to understand the underlying mechanism. Welding and cutting are sequentially simulated by finite element models which have been validated by previous experimental results. It is found that a cutting direction normal to the symmetry plane of the residual stress distribution can lead to a substantially asymmetrical back-calculated stress distribution, owing to cutting-induced plasticity. In general, the stresses at sample edges are most susceptible to error, particularly when the sample is restrained during cutting. Inadequate clamping (far from the plane of cut) can lead to highly concentrated plastic deformation in local regions, and consequently the back-calculated stresses have exceptionally high values and gradients at these locations. Furthermore, the overall stress distribution is skewed towards the end-of-cut side. Adequate clamping (close to the plane of cut) minimises errors in back-calculated stress which becomes insensitive to the cutting direction. For minimal constraint (i.e. solely preventing rigid body motion), the plastic deformation is relatively smoothly distributed, and an optimal cutting direction (i.e. cutting from the base material towards the weld region in a direction that falls within the residual stress symmetry plane) is identified by evaluating the magnitude of stress errors. These findings suggest that cutting process information is important for the evaluation of potential plasticity-induced errors in contour method results, and that the cutting direction and clamping strategy can be optimised with an understanding of their effects on plasticity and hence the back-calculated stresses
Constraints on the Progenitor of SN 2016gkg From Its Shock-Cooling Light Curve
SN 2016gkg is a nearby Type IIb supernova discovered shortly after explosion.
Like several other Type IIb events with early-time data, SN 2016gkg displays a
double-peaked light curve, with the first peak associated with the cooling of a
low-mass extended progenitor envelope. We present unprecedented
intranight-cadence multi-band photometric coverage of the first light-curve
peak of SN 2016gkg obtained from the Las Cumbres Observatory Global Telescope
network, the Asteroid Terrestrial-impact Last Alert System, the Swift satellite
and various amateur-operated telescopes. Fitting these data to analytical
shock-cooling models gives a progenitor radius of ~25-140 solar radii with
~2-30 x 10^-2 solar masses of material in the extended envelope (depending on
the model and the assumed host-galaxy extinction). Our radius estimates are
broadly consistent with values derived independently (in other works) from HST
imaging of the progenitor star. However, the shock-cooling model radii are on
the lower end of the values indicated by pre-explosion imaging. Hydrodynamical
simulations could refine the progenitor parameters deduced from the
shock-cooling emission and test the analytical models.Comment: Accepted by ApJ
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