A frequency-adjustable electromagnet for hyperthermia measurements on magnetic nanoparticles

We describe a low-cost and simple setup for hyperthermia measurements on colloidal solutions of magnetic nanoparticles (ferrofluids) with a frequency-adjustable magnetic field in the range 5-500 kHz produced by an electromagnet. By optimizing the general conception and each component (nature of the wires, design of the electromagnet), a highly efficient setup is obtained. For instance, in a useful gap of 1.1 cm, a magnetic field of 4.8 mT is generated at 100 kHz and 500 kHz with an output power of 3.4 W and 75 W, respectively. A maximum magnetic field of 30 mT is obtained at 100 kHz. The temperature of the colloidal solution is measured using optical fiber sensors. To remove contributions due to heating of the electromagnet, a differential measurement is used. In this configuration the sensitivity is better than 1.5 mW at 100 kHz and 19.3 mT. This setup allows one to measure weak heating powers on highly diluted colloidal solutions. The hyperthermia characteristics of a solution of Fe nanoparticles are described, where both the magnetic field and the frequency dependence of heating power have been measured

Higher-order-in-spin interaction Hamiltonians for binary black holes from source terms of Kerr geometry in approximate ADM coordinates

The Kerr metric outside the ergosphere is transformed into ADM coordinates up to the orders $1/r^4$ and $a^2$, respectively in radial coordinate $r$ and reduced angular momentum variable $a$, starting from the Kerr solution in quasi-isotropic as well as harmonic coordinates. The distributional source terms for the approximate solution are calculated. To leading order in linear momenta, higher-order-in-spin interaction Hamiltonians for black-hole binaries are derived.Comment: REVTeX4, 20 pages, typos corrected in Eq. (124) and (130

Large specific absorption rates in the magnetic hyperthermia properties of metallic iron nanocubes

We report on the magnetic hyperthermia properties of chemically synthesized ferromagnetic 11 and 16 nm Fe(0) nanoparticles of cubic shape displaying the saturation magnetization of bulk iron. The specific absorption rate measured on 16 nm nanocubes is 1690+-160 W/g at 300 kHz and 66 mT. This corresponds to specific losses-per-cycle of 5.6 mJ/g, largely exceeding the ones reported in other systems. A way to quantify the degree of optimization of any system with respect to hyperthermia applications is proposed. Applied here, this method shows that our nanoparticles are not fully optimized, probably due to the strong influence of magnetic interactions on their magnetic response. Once protected from oxidation and further optimized, such nano-objects could constitute efficient magnetic cores for biomedical applications requiring very large heating power

Reduced Hamiltonian for next-to-leading order Spin-Squared Dynamics of General Compact Binaries

Within the post Newtonian framework the fully reduced Hamiltonian (i.e., with eliminated spin supplementary condition) for the next-to-leading order spin-squared dynamics of general compact binaries is presented. The Hamiltonian is applicable to the spin dynamics of all kinds of binaries with self-gravitating components like black holes and/or neutron stars taking into account spin-induced quadrupolar deformation effects in second post-Newtonian order perturbation theory of Einstein's field equations. The corresponding equations of motion for spin, position and momentum variables are given in terms of canonical Poisson brackets. Comparison with a nonreduced potential calculated within the Effective Field Theory approach is made.Comment: 11 pages, minor changes to match published version at CQ

Spin induced multipole moments for the gravitational wave flux from binary inspirals to third Post-Newtonian order

Using effective field theory techniques we calculate the source multipole moments needed to obtain the spin contributions to the power radiated in gravitational waves from inspiralling compact binaries to third Post-Newtonian order (3PN). The multipoles depend linearly and quadratically on the spins and include both spin(1)spin(2) and spin(1)spin(1) components. The results in this paper provide the last missing ingredient required to determine the phase evolution to 3PN including all spin effects which we will report in a separate paper.Comment: 35 pages, 7 figures. Published versio

Motion and gravitational wave forms of eccentric compact binaries with orbital-angular-momentum-aligned spins under next-to-leading order in spin-orbit and leading order in spin(1)-spin(2) and spin-squared couplings

A quasi-Keplerian parameterisation for the solutions of second post-Newtonian (PN) accurate equations of motion for spinning compact binaries is obtained including leading order spin-spin and next-to-leading order spin-orbit interactions. Rotational deformation of the compact objects is incorporated. For arbitrary mass ratios the spin orientations are taken to be parallel or anti-parallel to the orbital angular momentum vector. The emitted gravitational wave forms are given in analytic form up to 2PN point particle, 1.5PN spin orbit and 1PN spin-spin contributions, where the spins are counted of 0PN order.Comment: 26 pages, 1 figure, published in CQG. Current version: we removed a remark and clarified the derivation of the orbital element \e_ph

Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution