Reproductive biology of hilsa shad (Tenualosa ilisha) in coastal waters of the northwest of Persian Gulf

Some aspects of the reproductive biology of Hilsa Shad, Tenualosa ilisha from the Persian Gulf and rivers of Khouzestan Province of Iran were analyzed. A total of 485 fish were sampled by gillnet from landing center of Arvand (AR) and Bahmanshir (BR) rivers during period of April 2010 to September 2010. Reproductive characteristic of T. ilisha showed that sex ratio is M:F=1:2, in PG, AR and BR. This means that females predominate than males. Monthly variations in Gonadosomatic Index (GSI) of both sexes were quite apparent. In PG, maximum values were recorded in April for male and female. In AR and BR, maximum values were recorded in June and May for male and female, respectively. Changes in GSI indices are considered as a proof that maturation season in AR and BR is started from March and spawning is started from April to July in AR and BR is started from March to August. The Length - Weight relationship was measured for PG as W= 1.459L^2.687, AR and BR as W=2.189L^3.166 and W=1.840L^2.937, respectively

An Introduction: Adapting to a Rapidly Changing World

The 2015 American Society of International Law (ASIL) Annual Meeting aimed to assess how international law is and should be adapting to the profound global changes that are now underway. The Meeting took place against a dramatic backdrop of events: the rapid expansion of the so-called Islamic State in Syria and Iraq; a security and refugee crisis in the Middle East; escalating conflict in Eastern Ukraine and Crimea; an Ebola crisis in West Africa; and the build-up to a widely anticipated round of negotiations on climate change. These and similar geopolitical developments raise serious questions about the continued relevance and adequacy of existing international legal arrangements and institutions. For example, are the traditional processes for making international law capable of effectively and legitimately addressing these challenges? Can existing international institutions maintain their relevance in an increasingly multi-polar system? And how should the world tackle complex problems such as the proliferation of violence among non-state actors, degradation of the global environment, and persistent levels of severe poverty

The embryonic development and formation of Bunnei (Barbus sharpeyi Gunther, 1874)

Understanding the embryogenesis of Bunni is a useful tool for finding the time and suitable environmental conditions for spawning, growth requirements and use of techniques to increase the growth rate and survival. The stages of embryonic development for Bunnei (Barbus sharpeyi) was investigated in 22°C. The reared brood stocks were spawned in captivity condition. The oocytes were spherical, brown and very adhesive. The cleavage was fast and the first division was recorded within 15-20 minutes after fertilization. The blastulation and gastrulation were investigated in 7:40 and 13:10 hours after fertilization with the yolk sac diameter of 1.18±0.061mm (Mean±SD), respectively. The organogenesis was started 21 hours after the fertilization, when the blastopore was closed and notochord was formed. The embryonic stages were continued by appearance the brain, the somites and the melanophores on the yolk sac. The heart was beaten and shown the blood circulation 65 hours after the fertilization. The head, tail and pectoral fins were moved frequently. The embryo reached to pre hatching and final hatching 79:10 and 84:10 hours after fertilization, respectively, and the embryo existed from corion with the length of about 5.29±0/121mm (Mean±SD)

Pan-urologic cancer genomic subtypes that transcend tissue of origin

AbstractUrologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of multidimensional and comprehensive molecular characterization (including DNA methylation and copy number, and RNA and protein expression). Tissue dominant effects are first removed computationally in order to define these subtypes, which reveal common processes—reflecting in part tumor microenvironmental influences—driving cellular behavior across tumor lineages. Six of the subtypes feature a mixture of represented cancer types as defined by tissue or cell of origin. Differences in patient survival and in the manifestation of specific pathways—including hypoxia, metabolism, NRF2-ARE, Hippo, and immune checkpoint—can further distinguish the subtypes. Immune checkpoint markers and molecular signatures of macrophages and T cell infiltrates are relatively high within distinct subsets of each cancer type studied. The pan-urologic cancer genomic subtypes would facilitate information sharing involving therapeutic implications between tissue-oriented domains.</jats:p

Sea Level in the Strait of Gibraltar: Tides

A network of tide gauges with eight observation recording points was in operation in the Strait of Gibraltar during the years 1984 and 1985, which made it possible to draw up detailed charts of the tides showing their refined structure. For the first order, the Strait of Gibraltar represents the nodal line of the stationary wave of the western Mediterranean, which, hypothetically, would end at the Cadiz meridian (6°17.0W). The tide is basically semi-diurnal; on average, 90% of the energy is associated with the second order and, for this, the Strait of Gibraltar tends to represent an antinode of the stationary wave, although the influence of the bottom topography and the rotation is interpreted in phase delays in the sill area (slightly progressive wave) and in increased non-linear constituents of higher orders. The radiational tide S is evaluated in the area studied and it is ascertained that it shows the same characteristics as the tides having strictly gravitational constituents, which implies that it is fundamentally co-oscillating. Order 4 displays characteristics of resonant amplification due to the existence of the free oscillation mode of the western Mediterranean basin the period of which is close to 6 hours. Of order 3 it should be stressed that M3, though small, is perfectly detectable in the area

The effect of mirabegron on patient-related outcomes in patients with overactive bladder: the results of post hoc correlation and responder analyses using pooled data from three randomized Phase III trials

Purpose To understand how improvements in the symptoms of overactive bladder (OAB) seen with the b3-adrenoceptor agonist mirabegron 50 mg, correlate with patient experience as measured by validated and standard patient-reported outcomes (PROs), and to identify whether there is overall directional consistency in the responsiveness of PROs to treatment effect. Methods In a post hoc analysis of pooled data from three randomized, double-blind, placebo-controlled, 12-week Phase III trials of mirabegron 50 mg once daily, responder rates for incontinence frequency (C50 % reduction in incontinence episodes/24 h from baseline to final visit), micturition frequency (B8 micturitions/24 h at final visit), and PROs [minimally important differences in patient perception of bladder condition (PPBC) and subsets of the overactive bladder questionnaire (OAB-q) measuring total health-related quality of life (HRQoL), and symptom bother] were evaluated individually and in combination. Results Mirabegron 50 mg demonstrated greater improvement from baseline to final visit than placebo for each of the responder analyses, whether for individual objective and subjective outcomes or combinations thereof. These improvements versus placebo were statistically significant for all double and triple responder analyses and for all single responder analyses except PPBC. PRO measurements showed directional consistency and significant correlations, and there were also significant correlations between objective and subjective measures of efficacy. Conclusions The improvements in objective measures seen with mirabegron 50 mg translate into a meaningful clinical benefit as evident by the directional consistency seen in HRQoL measures of benefit

Multi-Scale Characterization of the PEPCK-Cmus Mouse through 3D Cryo-Imaging

We have developed, for the Case 3D Cryo-imaging system, a specialized, multiscale visualization scheme which provides color-rich volume rendering and multiplanar reformatting enabling one to visualize an entire mouse and zoom in to organ, tissue, and microscopic scales. With this system, we have anatomically characterized, in 3D, from whole animal to tissue level, a transgenic mouse and compared it with its control. The transgenic mouse overexpresses the cytosolic form of phosphoenolpyruvate carboxykinase (PEPCK-C) in its skeletal muscle and is capable of greatly enhanced physical endurance and has a longer life-span and reproductive life as compared to control animals. We semiautomatically analyzed selected organs such as kidney, heart, adrenal gland, spleen, and ovaries and found comparatively enlarged heart, much less visceral, subcutaneous, and pericardial adipose tissue, and higher tibia-to-femur ratio in the transgenic animal. Microscopically, individual skeletal muscle fibers, fine mesenteric blood vessels, and intestinal villi, among others, were clearly seen

Global clustering coefficient in scale-free networks

In this paper, we analyze the behavior of the global clustering coefficient in scale free graphs. We are especially interested in the case of degree distribution with an infinite variance, since such degree distribution is usually observed in real-world networks of diverse nature. There are two common definitions of the clustering coefficient of a graph: global clustering and average local clustering. It is widely believed that in real networks both clustering coefficients tend to some positive constant as the networks grow. There are several models for which the average local clustering coefficient tends to a positive constant. On the other hand, there are no models of scale-free networks with an infinite variance of degree distribution and with a constant global clustering. In this paper we prove that if the degree distribution obeys the power law with an infinite variance, then the global clustering coefficient tends to zero with high probability as the size of a graph grows