33 research outputs found
A collaborative agenda for archaeology and fire science
Humans have influenced global fire activity for millennia and will continue to do so into the future. Given the long-term interaction between humans and fire, we propose a collaborative research agenda linking archaeology and fire science that emphasizes the socioecological histories and consequences of anthropogenic fire in the development of fire management strategies today.Role for archaeology in fire science A collaborative research agenda Resolving collaborative challenge
Ebooks and Interlibrary Loan: Licensed to Fill?
Increasingly, libraries of all types and sizes are now adding electronic book (ebook) titles to their collections. A survey was used to explore the implications of ebook licensing and interlibrary loan use. Among academic libraries in the United States a widespread preference for handling print books was found along with a need for more information about ebook interlibrary loan rights at oneās own institution and a means to identify format type available from potential lending libraries
Deconstructing the <i>Iboga</i> Alkaloid Skeleton: Potentiation of FGF2-induced Glial Cell Line-Derived Neurotrophic Factor Release by a Novel Compound
Modulation of growth factor signaling
pathways in the brain represents
a new experimental approach to treating neuropsychiatric disorders
such as depression, anxiety, and addiction. Neurotrophins and growth
factors exert synaptic, neuronal, and circuit level effects on a wide
temporal range, which suggests a possibility of rapid and lasting
therapeutic effects. Consequently, identification of small molecules
that can either enhance the release of growth factors or potentiate
their respective pathways will provide a drug-like alternative to
direct neurotrophin administration or viral gene delivery and thus
represents an important frontier in chemical biology and drug design.
Glial cell line-derived neurotrophic factor (GDNF), in particular,
has been implicated in marked reduction of alcohol consumption in
rodent addiction models, and the natural product ibogaine, a substance
used traditionally in ritualistic ceremonies, has been suggested to
increase the synthesis and release of GDNF in the dopaminergic system
in rats. In this report, we describe a novel <i>iboga</i> analog, XL-008, created by unraveling the medium size ring of the
ibogamine skeleton, and its ability to induce release of GDNF in C6
glioma cells. Additionally, XL-008 potentiates the release of GDNF
induced by fibroblast growth factor 2 (FGF2), another neurotrophin
implicated in major depressive disorder, increasing potency more than
2-fold (from 7.85 Ā± 2.59 ng/mL to 3.31 Ā± 0.98 ng/mL) and
efficacy more than 3-fold. The GDNF release by both XL-008 and the
FGF2/XL-008 mixture was found to be mediated through the MEK and PI3K
signaling pathways but not through PLCĪ³ in C6 glioma cells