3,465 research outputs found

    The Impact of Sensory Deprivation and Sensory-Based Intervention for Incarcerated Adults Over the Age of 65

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    This critically appraised topic (CAT) focuses on sensory-based interventions for improving the quality of life for older adults who are incarcerated in the United States. There are many aspects to this topic; sensory deprivation in the prison system is addressed first, followed by the importance of sensory-based interventions, and finally the relationship between occupational therapy and quality of life

    Central blockade of oxytocin receptors during mid-late gestation reduces amplitude of slow afterhyperpolarization in supraoptic oxytocin neurons

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    The neurohypophysial hormone oxytocin (OT), synthesized in magnocellular paraventricular (PVN) and supraoptic (SON) nuclei, is well known for its effects in lactation. Our previous studies showed that central OT receptor (OTR) binding is increased during gestation and that blockade of central OTRs, specifically during mid-late gestation, causes a delay in OT release during suckling and reduces weight gain in pups, suggesting decreased milk delivery. In the present study, we tested whether central OTR blockade during late gestation disrupts the gestation-related plasticity in intrinsic membrane properties. Whole cell current-clamp recordings were performed in OT neurons from pregnant rats (19-22 days in gestation) that were infused with an OTR antagonist (OTA) or artificial cerebrospinal fluid (aCSF) and from virgin rats infused with aCSF into the third ventricle via an osmotic minipump beginning on days 12-14 of gestation. The amplitudes of both Ca2+-dependent afterhyperpolarizations (AHPs), an apamin-sensitive medium AHP (mAHP) and an apamin-insensitive slow AHP (sAHP), were significantly increased during late gestation in control pregnant animals. However, the amplitude of the sAHP from pregnant rats treated with the OTA was significantly smaller than that of pregnant control rats and similar to that of virgins. These results indicate that the diminished efficiency in lactation due to OTR blockade may be partly a result of an altered sAHP that would shape OT bursting. These findings suggest that central actions of OT during late gestation are necessary for programming the plasticity of at least some of the intrinsic membrane properties in OT neurons during lactation. Copyright © 2008 the American Physiological Society

    Characterizing Atacama B-mode Search Detectors with a Half-Wave Plate

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    The Atacama B-Mode Search (ABS) instrument is a cryogenic (\sim10 K) crossed-Dragone telescope located at an elevation of 5190 m in the Atacama Desert in Chile that observed for three seasons between February 2012 and October 2014. ABS observed the Cosmic Microwave Background (CMB) at large angular scales (40<<50040<\ell<500) to limit the B-mode polarization spectrum around the primordial B-mode peak from inflationary gravity waves at 100\ell \sim100. The ABS focal plane consists of 480 transition-edge sensor (TES) bolometers. They are coupled to orthogonal polarizations from a planar ortho-mode transducer (OMT) and observe at 145 GHz. ABS employs an ambient-temperature, rapidly rotating half-wave plate (HWP) to mitigate systematic effects and move the signal band away from atmospheric 1/f1/f noise, allowing for the recovery of large angular scales. We discuss how the signal at the second harmonic of the HWP rotation frequency can be used for data selection and for monitoring the detector responsivities.Comment: 7 pages, 3 figures, conference proceedings submitted to the Journal of Low Temperature Detector

    Self-forces on extended bodies in electrodynamics

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    In this paper, we study the bulk motion of a classical extended charge in flat spacetime. A formalism developed by W. G. Dixon is used to determine how the details of such a particle's internal structure influence its equations of motion. We place essentially no restrictions (other than boundedness) on the shape of the charge, and allow for inhomogeneity, internal currents, elasticity, and spin. Even if the angular momentum remains small, many such systems are found to be affected by large self-interaction effects beyond the standard Lorentz-Dirac force. These are particularly significant if the particle's charge density fails to be much greater than its 3-current density (or vice versa) in the center-of-mass frame. Additional terms also arise in the equations of motion if the dipole moment is too large, and when the `center-of-electromagnetic mass' is far from the `center-of-bare mass' (roughly speaking). These conditions are often quite restrictive. General equations of motion were also derived under the assumption that the particle can only interact with the radiative component of its self-field. These are much simpler than the equations derived using the full retarded self-field; as are the conditions required to recover the Lorentz-Dirac equation.Comment: 30 pages; significantly improved presentation; accepted for publication in Phys. Rev.

    A hybrid kinetic Monte Carlo method for simulating silicon films grown by plasma-enhanced chemical vapor deposition

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    We present a powerful kinetic Monte Carlo (KMC) algorithm that allows one to simulate the growth of nanocrystalline silicon by plasma enhanced chemical vapor deposition (PECVD) for film thicknesses as large as several hundreds of monolayers. Our method combines a standard n-fold KMC algorithm with an efficient Markovian random walk scheme accounting for the surface diffusive processes of the species involved in PECVD. These processes are extremely fast compared to chemical reactions, thus in a brute application of the KMC method more than 99% of the computational time is spent in monitoring them. Our method decouples the treatment of these events from the rest of the reactions in a systematic way, thereby dramatically increasing the efficiency of the corresponding KMC algorithm. It is also making use of a very rich kinetic model which includes 5 species (H, SiH3, SiH2, SiH, and Si 2H5) that participate in 29 reactions. We have applied the new method in simulations of silicon growth under several conditions (in particular, silane fraction in the gas mixture), including those usually realized in actual PECVD technologies. This has allowed us to directly compare against available experimental data for the growth rate, the mesoscale morphology, and the chemical composition of the deposited film as a function of dilution ratio.open1
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