1,181 research outputs found
Experimental test of higher-order Laguerre–Gauss modes in the 10 m Glasgow prototype interferometer
Brownian noise of dielectric mirror coatings is expected to be one of the limiting noise sources, at the peak sensitivity, of next generation ground based interferometric gravitational wave (GW) detectors. The use of higher-order Laguerre–Gauss (LG) beams has been suggested to reduce the effect of coating thermal noise in future generations of gravitational wave detectors. In this paper we describe the first test of interferometry with higher-order LG beams in an environment similar to a full-scale gravitational wave detector. We compare the interferometric performance of higher-order LG modes and the fundamental mode beams, injected into a 10 m long suspended cavity that features a finesse of 612, a value chosen to be typical of future gravitational wave detectors. We found that the expected mode degeneracy of the injected LG3, 3 beam was resolved into a multiple peak structure, and that the cavity length control signal featured several nearby zero crossings. The break up of the mode degeneracy is due to an astigmatism (defined as |Rcy − Rcx|) of 5.25 ± 0.5 cm on one of our cavity mirrors with a radius of curvature (Rc) of 15 m. This observation agrees well with numerical simulations developed with the FINESSE software. We also report on how these higher-order mode beams respond to the misalignment and mode mismatch present in our 10 m cavity. In general we found the LG3, 3 beam to be considerably more susceptible to astigmatism and mode mismatch than a conventional fundamental mode beam. Therefore the potential application of higher-order Laguerre–Gauss beams in future gravitational wave detectors will impose much more stringent requirements on both mode matching and mirror astigmatism
Generation of high-purity higher-order Laguerre-Gauss beams at high laser power
We have investigated the generation of highly pure higher-order
Laguerre-Gauss (LG) beams at high laser power of order 100W, the same regime
that will be used by 2nd generation gravitational wave interferometers such as
Advanced LIGO. We report on the generation of a helical type LG33 mode with a
purity of order 97% at a power of 83W, the highest power ever reported in
literature for a higher-order LG mode.Comment: 5 pages, 6 figure
Impact of providing patients access to electronic health records on quality and safety of care: a systematic review and meta-analysis
Objective To evaluate the impact of sharing electronic health records (EHRs) with patients and map it across six domains of quality of care (ie, patient-centredness, effectiveness, efficiency, timeliness, equity and safety). Design Systematic review and meta-analysis. Data sources CINAHL, Cochrane, Embase, HMIC, Medline/PubMed and PsycINFO, from 1997 to 2017. Eligibility criteria Randomised trials focusing on adult subjects, testing an intervention consisting of sharing EHRs with patients, and with an outcome in one of the six domains of quality of care. Data analysis The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Title and abstract screening were performed by two pairs of investigators and assessed using the Cochrane Risk of Bias Tool. For each domain, a narrative synthesis of the results was performed, and significant differences in results between low risk and high/unclear risk of bias studies were tested (t-test, p<0.05). Continuous outcomes evaluated in four studies or more (glycated haemoglobin (HbA1c), systolic blood pressure (SBP) and diastolic blood pressure (DBP)) were pooled as weighted mean difference (WMD) using random effects meta-analysis. Sensitivity analyses were performed for low risk of bias studies, and long-term interventions only (lasting more than 12 months). Results Twenty studies were included (17 387 participants). The domain most frequently assessed was effectiveness (n=14), and the least were timeliness and equity (n=0). Inconsistent results were found for patient-centredness outcomes (ie, satisfaction, activation, self-efficacy, empowerment or health literacy), with 54.5% of the studies (n=6) demonstrating a beneficial effect. Meta-analyses showed a beneficial effect in effectiveness by reducing absolute values of HbA1c (unit: %; WMD=−0.316; 95% CI −0.540 to −0.093, p=0.005, I2=0%), which remained significant in the sensitivity analyses for low risk of bias studies (WMD= −0.405; 95% CI −0.711 to −0.099), and long-term interventions only (WMD=−0.272; 95% CI −0.482 to −0.062). A significant reduction of absolute values of SBP (unit: mm Hg) was found but lost in sensitivity analysis for studies with low risk of bias (WMD= −1.375; 95% CI −2.791 to 0.041). No significant effect was found for DBP (unit: mm Hg; WMD=−0.918; 95% CI −2.078 to 0.242, p=0.121, I2=0%). Concerning efficiency, most studies (80%, n=4) found either a reduction of healthcare usage or no change. A beneficial effect was observed in a range of safety outcomes (ie, general adherence, medication safety), but not in medication adherence. The proportion of studies reporting a beneficial effect did not differ between low risk and high/unclear risk studies, for the domains evaluated. Discussion Our analysis supports that sharing EHRs with patients is effective in reducing HbA1c levels, a major predictor of mortality in type 2 diabetes (mean decrease of −0.405, unit: %) and could improve patient safety. More studies are necessary to enhance meta-analytical power and assess the impact in other domains of care. Protocol registration http://www.crd.york.ac.uk/PROSPERO (CRD42017070092)
Non-mean-field theory of anomalously large double-layer capacitance
Mean-field theories claim that the capacitance of the double-layer formed at
a metal/ionic conductor interface cannot be larger than that of the Helmholtz
capacitor, whose width is equal to the radius of an ion. However, in some
experiments the apparent width of the double-layer capacitor is substantially
smaller. We propose an alternate, non-mean-field theory of the ionic
double-layer to explain such large capacitance values. Our theory allows for
the binding of discrete ions to their image charges in the metal, which results
in the formation of interface dipoles. We focus primarily on the case where
only small cations are mobile and other ions form an oppositely-charged
background. In this case, at small temperature and zero applied voltage dipoles
form a correlated liquid on both contacts. We show that at small voltages the
capacitance of the double-layer is determined by the transfer of dipoles from
one electrode to the other and is therefore limited only by the weak
dipole-dipole repulsion between bound ions, so that the capacitance is very
large. At large voltages the depletion of bound ions from one of the capacitor
electrodes triggers a collapse of the capacitance to the much smaller
mean-field value, as seen in experimental data. We test our analytical
predictions with a Monte Carlo simulation and find good agreement. We further
argue that our ``one-component plasma" model should work well for strongly
asymmetric ion liquids. We believe that this work also suggests an improved
theory of pseudo-capacitance.Comment: 19 pages, 14 figures; some Monte Carlo results and a section about
aqueous solutions adde
Review of the Laguerre-Gauss mode technology research program at Birmingham
Gravitational wave detectors from the advanced generation onwards are
expected to be limited in sensitivity by thermal noise of the optics, making
the reduction of this noise a key factor in the success of such detectors. A
proposed method for reducing the impact of this noise is to use higher-order
Laguerre-Gauss (LG) modes for the readout beam, as opposed to the currently
used fundamental mode. We present here a synopsis of the research program
undertaken by the University of Birmingham into the suitability of LG mode
technology for future gravitational wave detectors. This will cover our
previous and current work on this topic, from initial simulations and table-top
LG mode experiments up to implementation in a prototype scale suspended cavity
and high-power laser bench
Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.
The advent of large-scale in vitro differentiation of human stem cell-derived insulin-producing cells (SCIPC) has brought us closer to treating diabetes using stem cell technology. However, decades of experiences from islet transplantation show that ischemia-induced islet cell death after transplant severely limits the efficacy of the therapy. It is unclear to what extent human SCIPC are susceptible to ischemia. In this study, we show that more than half of SCIPC die shortly after transplantation. Nutrient deprivation and hypoxia acted synergistically to kill SCIPC in vitro. Amino acid supplementation rescued SCIPC from nutrient deprivation, likely by providing cellular energy. Generating SCIPC under physiological oxygen tension of 5% conferred hypoxia resistance without affecting their differentiation or function. A two-pronged strategy of physiological oxygen acclimatization during differentiation and amino acid supplementation during transplantation significantly improved SCIPC survival after transplant
Probing seed black holes using future gravitational-wave detectors
Identifying the properties of the first generation of seeds of massive black
holes is key to understanding the merger history and growth of galaxies.
Mergers between ~100 solar mass seed black holes generate gravitational waves
in the 0.1-10Hz band that lies between the sensitivity bands of existing
ground-based detectors and the planned space-based gravitational wave detector,
the Laser Interferometer Space Antenna (LISA). However, there are proposals for
more advanced detectors that will bridge this gap, including the third
generation ground-based Einstein Telescope and the space-based detector DECIGO.
In this paper we demonstrate that such future detectors should be able to
detect gravitational waves produced by the coalescence of the first generation
of light seed black-hole binaries and provide information on the evolution of
structure in that era. These observations will be complementary to those that
LISA will make of subsequent mergers between more massive black holes. We
compute the sensitivity of various future detectors to seed black-hole mergers,
and use this to explore the number and properties of the events that each
detector might see in three years of observation. For this calculation, we make
use of galaxy merger trees and two different seed black hole mass distributions
in order to construct the astrophysical population of events. We also consider
the accuracy with which networks of future ground-based detectors will be able
to measure the parameters of seed black hole mergers, in particular the
luminosity distance to the source. We show that distance precisions of ~30% are
achievable, which should be sufficient for us to say with confidence that the
sources are at high redshift.Comment: 14 pages, 6 figures, 2 tables, accepted for proceedings of 13th GWDAW
meetin
DC-readout of a signal-recycled gravitational wave detector
All first-generation large-scale gravitational wave detectors are operated at
the dark fringe and use a heterodyne readout employing radio frequency (RF)
modulation-demodulation techniques. However, the experience in the currently
running interferometers reveals several problems connected with a heterodyne
readout, of which phase noise of the RF modulation is the most serious one. A
homodyne detection scheme (DC-readout), using the highly stabilized and
filtered carrier light as local oscillator for the readout, is considered to be
a favourable alternative. Recently a DC-readout scheme was implemented on the
GEO 600 detector. We describe the results of first measurements and give a
comparison of the performance achieved with homodyne and heterodyne readout.
The implications of the combined use of DC-readout and signal-recycling are
considered.Comment: 11 page
Prospects for detecting gravitational waves at 5 Hz with ground-based detectors
We propose an upgrade to Advanced LIGO (aLIGO), named LIGO-LF, that focuses
on improving the sensitivity in the 5-30 Hz low-frequency band, and we explore
the upgrade's astrophysical applications. We present a comprehensive study of
the detector's technical noises and show that with technologies currently under
development, such as interferometrically sensed seismometers and
balanced-homodyne readout, LIGO-LF can reach the fundamental limits set by
quantum and thermal noises down to 5 Hz. These technologies are also directly
applicable to the future generation of detectors. We go on to consider this
upgrade's implications for the astrophysical output of an aLIGO-like detector.
A single LIGO-LF can detect mergers of stellar-mass black holes (BHs) out to a
redshift of z~6 and would be sensitive to intermediate-mass black holes up to
2000 M_\odot. The detection rate of merging BHs will increase by a factor of 18
compared to aLIGO. Additionally, for a given source the chirp mass and total
mass can be constrained 2 times better than aLIGO and the effective spin 3-5
times better than aLIGO. Furthermore, LIGO-LF enables the localization of
coalescing binary neutron stars with an uncertainty solid angle 10 times
smaller than that of aLIGO at 30 Hz, and 4 times smaller when the entire signal
is used. LIGO-LF also significantly enhances the probability of detecting other
astrophysical phenomena including the tidal excitation of neutron star r-modes
and the gravitational memory effects.Comment: 5 pages, 6 figures, published in PR
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