51 research outputs found
Analysis of the variability of nursing care by pathology in a sample of nine Belgian hospitals
info:eu-repo/semantics/published27th Patient Classification Systems International (PCSI) Working Conference, Montreal, Canada, October 201
Effetti dellâinquinamento da plastiche sui foraminiferi bentonici
Le plastiche sono divenuti contaminanti ubiquitari negli ecosistemi marini, dâacqua dolce e terrestri
che producono rilevanti impatti sulle specie che in essi vivono. Dal 1950 ad oggi sono stati accumulati
nellâambiente circa 5 miliardi di tonnellate di plastica (Geyer et al., 2017). I meccanismi di interazione tra
microplastiche e biosfera nonché gli effetti biochimici delle molecole sintetiche, specialmente sugli organismi
eucariotici unicellulari marini, sono scarsamente studiati. In particolare, i foraminiferi bentonici costituiscono
una componente fondamentale delle comunitĂ marine e svolgono un ruolo chiave nel funzionamento
dellâecosistema e nei cicli biogeochimici. La loro sensibilitĂ e la rapida risposta allo stress ambientale li
rendono efficienti indicatori dei cambiamenti climatici e ambientali attuali e del passato (Schönfeld et al.,
2012).Per comprendere meglio lâeffetto delle plastiche negli oceani e negli organismi marini, abbiamo valutato
lâincorporazione di (bio)polimeri e microplastiche in foraminiferi bentonici utilizzando tecniche di spettromicroscopia
ad infrarossi in trasformata di Fourier (ÎŒFTIR).
In questo studio, abbiamo raccolto ed analizzato spettri ed immagini ÎŒFTIR dauna selezione di specie
di foraminiferi bentonici: Rosalina globularis cresciuta in colture inquinate con la plastica e Cibicidoides
lobatulus, Rosalina bradyi e Textularia bocki raccolti su un frammento di plastica trovato sepolto in un
sedimento del fondale del Mar Mediterraneo. In particolare, i foraminiferi provenienti dalle colture sono stati
intossicati con molecola di di-2-etilesilftalato (DEHP) allo scopo di valutarne lâincorporazione nel citoplasma.
Questo studio ha permesso di documentare: (1) la presenza di microplastiche nel citoplasma e nel guscio
agglutinante di T. bocki; (2) segnali di stress ossidativo e di aggregazione proteica nella componente cellulare di
C. lobatulus, R. bradyi e T. bocki, ancorati alla busta di plastica; (3) lâincorporazione del DEHP nel citoplasma
di R. globularis.
Questo studio ha confermato il ruolo chiave svolto dai foraminiferi bentonici come proxy per la valutazione
degli effetti dellâinquinamento da microplastiche sia a livello cellulare che di biomineralizzazione confermando
lâingresso delle microplastiche e DEHP nei cicli biogeochimici.
Questa indagine ha inoltre dimostrato che la microscopia FTIR Ăš uno strumento efficace per studiare,
senza lâutilizzo di marcatori specifici, lâinterazione su scala molecolare tra plastica, citoplasma e guscio dei
foraminiferi
Corrigendum to âCirculating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluationâ
[This corrects the article DOI: 10.1155/2019/5879616.].Peer Reviewe
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Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation.
The recent introduction of the "precision medicine" concept in oncology pushed cancer research to focus on dynamic measurable biomarkers able to predict responses to novel anticancer therapies in order to improve clinical outcomes. Recently, the involvement of extracellular vesicles (EVs) in cancer pathophysiology has been described, and given their release from all cell types under specific stimuli, EVs have also been proposed as potential biomarkers in cancer. Among the techniques used to study EVs, flow cytometry has a high clinical potential. Here, we have applied a recently developed and simplified flow cytometry method for circulating EV enumeration, subtyping, and isolation from a large cohort of metastatic and locally advanced nonhaematological cancer patients (Nâ=â106); samples from gender- and age-matched healthy volunteers were also analysed. A large spectrum of cancer-related markers was used to analyse differences in terms of peripheral blood circulating EV phenotypes between patients and healthy volunteers, as well as their correlation to clinical outcomes. Finally, EVs from patients and controls were isolated by fluorescence-activated cell sorting, and their protein cargoes were analysed by proteomics. Results demonstrated that EV counts were significantly higher in cancer patients than in healthy volunteers, as previously reported. More interestingly, results also demonstrated that cancer patients presented higher concentrations of circulating CD31+ endothelial-derived and tumour cancer stem cell-derived CD133â+âCD326- EVs, when compared to healthy volunteers. Furthermore, higher levels of CD133â+âCD326- EVs showed a significant correlation with a poor overall survival. Additionally, proteomics analysis of EV cargoes demonstrated disparities in terms of protein content and function between circulating EVs in cancer patients and healthy controls. Overall, our data strongly suggest that blood circulating cancer stem cell-derived EVs may have a role as a diagnostic and prognostic biomarker in cancer
Geohazard features of the Tyrrhenian Calabria
This paper accompanies the Maps of Geohazard features of the Cilento and the Calabro-Tyrrhenian continental margin in the southern Tyrrhenian Sea (Italy). The main geohazard-related features were derived from extensive seafloor mapping through the collection of high-resolution multibeam data acquired during several oceanographic cruises. They encompass many fluids seepage features, fault scarps, landslides scars, gullies, channels, and canyons. Hazards related to coastal landslides and shelf-indenting canyons are very high in these sectors (especially in southern Calabria) due to active seismicity coupled with rapid uplift, high sedimentation rates and narrow or totally absent continental shelf, thus promoting a direct connection between steep slopes and coastal areas. In this setting, mass-wasting features can directly impact coastal or submarine infrastructures or indirectly create local tsunami waves, as observed in historical times. Moreover, this physiographic setting of the margin facilitates the transfer of marine litter toward deep-sea areas
The serological prevalence of SARS-CoV-2 infection in patients with chronic myeloid leukemia is similar to that in the general population
Background: Patients with hematological malignancies are at an increased risk of SARS-CoV-2 disease (COVID-19) and adverse outcome. However, a low mortality rate has been reported in patients with chronic myeloid leukemia (CML). Preclinical evidence suggests that tyrosine kinase inhibitors (TKIs) may have a protective role against severe COVID-19. Methods: We conducted a cross-sectional study of 564 consecutive patients with CML who were tested for anti-SARS-CoV-2 IgG/IgM antibodies at their first outpatient visit between May and early November 2020 in five hematologic centers representative of three Italian regions. Results: The estimated serological prevalence of SARS-CoV-2 infection in patients with CML after the first pandemic wave was similar to that in the general population (about 2%), both at national and regional levels. CML patients with positive anti-SARS-CoV-2\ua0serology were more frequently male (p\ua0=\ua00.027) and active workers (p\ua0=\ua00.012), while there was no significant association with TKI treatment type. Only 3 out of 11 IgG-positive patients had previously received a molecular diagnosis of COVID-19, while the remainders were asymptomatic or with mild symptoms. Conclusions: Our data confirm that the course of SARS-CoV-2 infection in patients with CML is generally mild and reassure about the safety of continuing TKIs during the COVID-19 pandemic. Furthermore, we suggest that patients with CML succeed to mount an antibody response after exposure to SARS-CoV-2, similar to the general population
Geohazard features of the north-western Sicily and Pantelleria
We present maps of geohazard features identified across north-western Sicily and Pantelleria in the framework of the Magic project (MArine Geohazard along Italian Coasts), which involved Italian marine geological researchers in 2007-2013. These seafloor features were recognized using high-resolution bathymetry data and rely on the morphological expression of the seafloor and shallow sub-surface processes. The north-western Sicily is a complex continental margin, affected by morphodynamic, depositional, and tectonic processes. The Egadi offshore is controlled by fault escarpments and alternating retreating and progradational processes. Ustica and Pantelleria submerged edifices show the effect of volcanic activity. The Ustica seafloor is interested in volcanic, tectonic, and gravitational instability processes, while the Pantelleria offshore underwent erosive-depositional processes and the effect of bottom currents. Two levels of interpretation are represented: the physiographic domain at a scale of 1:250.000 and the morphological units and morpho-bathymetric elements at a 1:100.000 scale
Geohazard features of the north-western Sicily and Pantelleria
9 pages, 3 figures, supplemental material https://doi.org/10.1080/17445647.2024.2342931.-- Data availability statement: Department of Earth and Marine Science of the University of Palermo for institutional purposes, so their access will be available by contacting the reference people (attilio.sulliunipa.it) upon reasonable requestWe present maps of geohazard features identified across north-western Sicily and Pantelleria in the framework of the Magic project (MArine Geohazard along Italian Coasts), which involved Italian marine geological researchers in 2007-2013. These seafloor features were recognized using high-resolution bathymetry data and rely on the morphological expression of the seafloor and shallow sub-surface processes. The north-western Sicily is a complex continental margin, affected by morphodynamic, depositional, and tectonic processes. The Egadi offshore is controlled by fault escarpments and alternating retreating and progradational processes. Ustica and Pantelleria submerged edifices show the effect of volcanic activity. The Ustica seafloor is interested in volcanic, tectonic, and gravitational instability processes, while the Pantelleria offshore underwent erosive-depositional processes and the effect of bottom currents. Two levels of interpretation are represented: the physiographic domain at a scale of 1:250.000 and the morphological units and morpho-bathymetric elements at a 1:100.000 scaleThe Magic Project has been funded by the Italian Civil Protection Department. [...] With the institutional support of the âSevero Ochoa Centre of Excellenceâ accreditation (CEX2019-000928-S)Peer reviewe
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