Color LAR codec : a color image representation and compression scheme based on local resolution adjustment and on self-extracting region representation

This LAR (Locally Adaptive Resolution) color image coding scheme yields to an efficient progressive compression with a better subjective quality than Jpeg2000. Additionally, it offers region functionalities for low bit rate coding and decoding. From highly compressed luminance, a region description, without contours encoding, can be obtained through a segmentation process performed at both coder and decoder. Considering color results, controlled chrominance components segmentation provides a better data consistency simultaneously with a low bit rate compression. As regions and their encoding are based on a same representation grid, enhancement of image quality can be global, or only restricted to a Region Of Interest.Cet article présente un schéma original de codage progressif d'images couleur apportant à la fois une efficacité en termes de compression (meilleure qualité subjective que Jpeg2000) et des fonctionnalités au niveau région à bas débits pour le codeur et le décodeur. À partir de l'image des luminances codée à bas débit par le codec LAR (Locally Adaptive Resolution), une description en régions, sans codage des contours, est obtenue à travers un procédé de segmentation effectué au codeur et au décodeur. Cette segmentation peut être contrôlée par les composantes chromatiques pour une meilleure cohérence du résultat d'un point de vue couleur. Un codage basé régions appliqué sur les images de chrominance produit alors une compression de ces composantes à très bas débit. Comme les régions et le codage de leur contenu partagent une même grille de représentation, l'amélioration de la qualité de l'image peut être globale, ou limitée à une zone d'intérêt

Th1 Disabled Function in Response to TLR4 Stimulation of Monocyte-Derived DC from Patients Chronically-Infected by Hepatitis C Virus

Background: Lack of protective antibodies and inefficient cytotoxic responses are characteristics of chronic hepatitis C infection. A defect in dendritic cell (DC) function has thus been suspected, but this remains a controversial issue. Methods and Findings: Here we show that monocyte-derived DC (MoDC) from chronically-infected patients can mature in response to TLR1/2, TLR2/6 or TLR3 ligands. In contrast, when stimulated with the TLR4 ligand LPS, MoDC from patients show a profound defect in inducing IFNc secretion by allogeneic T cells. This defect is not due to defective phenotypic maturation or to the presence of HCV-RNA in DC or monocytes but is correlated to reduced IL-12 secretion by DC. Restoration of DC ability to stimulate IFNc secretion can be obtained by blocking MEK activation in DC, indicating that MEK/ ERK pathway is involved in the Th1 defect of MoDC. Monocytes from HCV patients present increased spontaneous secretion of cytokines and chemokines, especially MIP-1b. Addition of MIP-1b on healthy monocytes during differentiation results in DC that have Th1 defect characteristic of MoDC from HCV patients, suggesting that MIP-1b secretion by HCV monocytes participates in the Th1 defect of DC. Conclusions: Our data indicate that monocytes from HCV patients are activated in vivo. This interferes with their differentiation into DC, leading to deficient TLR4 signaling in these cells that are enable to induce a Th1 response. Thi

Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence

Hepatitis C Virus (HCV) is a single stranded RNA virus which produces negative strand RNA as a replicative intermediate. We analyzed 75 RT-PCR studies that tested for negative strand HCV RNA in liver and other human tissues. 85% of the studies that investigated extrahepatic replication of HCV found one or more samples positive for replicative RNA. Studies using in situ hybridization, immunofluorescence, immunohistochemistry, and quasispecies analysis also demonstrated the presence of replicating HCV in various extrahepatic human tissues, and provide evidence that HCV replicates in macrophages, B cells, T cells, and other extrahepatic tissues. We also analyzed both short term and long term in vitro systems used to culture HCV. These systems vary in their purposes and methods, but long term culturing of HCV in B cells, T cells, and other cell types has been used to analyze replication. It is therefore now possible to study HIV-HCV co-infections and HCV replication in vitro

Cure of bartonella endocarditis of a prosthetic aortic valve without surgery: value of serologic follow-up

AbstractBartonella species are emerging as an important cause of blood culture-negative endocarditis, but the optimal management of this disease has not been fully defined. We describe a case of subacute Bartonella henselae endocarditis of a prosthetic aortic valve in an immunocompetent woman that was cured with long-term antibiotic therapy alone. In addition, we demonstrate that follow-up of serologic titers against B. henselae was helpful in assessing definitive cure of the infection