426 research outputs found
The radio emission from the Galaxy at 22 MHz
We present maps of the 22MHz radio emission between declinations -28d and
+80d, covering ~73% of the sky, derived from observations with the 22MHz
radiotelescope at the Dominion Radio Astrophysical Observatory (DRAO). The
resolution of the telescopt (EWxNS) is 1.1d x 1.7d secant(zenith angle). The
maps show the large scale features of the emission from the Galaxy including
the thick non-thermal disk, the North Polar Spur (NPS) and absorption due to
discrete HII regions and to an extended band of thermal electrons within 40d of
the Galactic centre. We give the flux densities of nine extended supernova
remnants shown on the maps
Radio Halo and Relic Candidates from the Westerbork Northern Sky Survey
We have undertaken a systematic search for diffuse radio halos and relics in
all of the Abell clusters that are visible in the Westerbork Northern Sky
Survey (WENSS). In this survey we found 18 candidates, 11 of which are already
known from the literature, and 7 for which we provide the first evidence of
diffuse radio emission. All the clusters in this sample show other evidence for
a recent or ongoing merger. We also investigate the correlation between cluster
X-ray luminosity and radio power of halos. We develop a very simple model for
merger shocks that reproduces the sense of this correlation, although it is
probably not as steep as the correlation in the data. We discuss the
implications of X-ray--radio correlations for future detections of radio halos.Comment: Accepted for publication in the Astrophysical Journal. 12 pages with
9 embedded Postscript figures in emulateapj5.sty. A higher resolution version
of the paper is available at
http://www.astro.virginia.edu/~jck7k/research/papers/WENSS.ps.g
Understanding consumer demand for new transport technologies and services, and implications for the future of mobility
The transport sector is witnessing unprecedented levels of disruption.
Privately owned cars that operate on internal combustion engines have been the
dominant modes of passenger transport for much of the last century. However,
recent advances in transport technologies and services, such as the development
of autonomous vehicles, the emergence of shared mobility services, and the
commercialization of alternative fuel vehicle technologies, promise to
revolutionise how humans travel. The implications are profound: some have
predicted the end of private car dependent Western societies, others have
portended greater suburbanization than has ever been observed before. If
transport systems are to fulfil current and future needs of different
subpopulations, and satisfy short and long-term societal objectives, it is
imperative that we comprehend the many factors that shape individual behaviour.
This chapter introduces the technologies and services most likely to disrupt
prevailing practices in the transport sector. We review past studies that have
examined current and future demand for these new technologies and services, and
their likely short and long-term impacts on extant mobility patterns. We
conclude with a summary of what these new technologies and services might mean
for the future of mobility.Comment: 15 pages, 0 figures, book chapte
Hydrologically-driven crustal stresses and seismicity in the New Madrid Seismic Zone
The degree to which short-term non-tectonic processes, either natural and anthropogenic, influence the occurrence of earthquakes in active tectonic settings or ‘stable’ plate interiors, remains a subject of debate. Recent work in plate-boundary regions demonstrates the capacity for long-wavelength changes in continental water storage to produce observable surface deformation, induce crustal stresses and modulate seismicity rates. Here we show that a significant variation in the rate of microearthquakes in the intraplate New Madrid Seismic Zone at annual and multi-annual timescales coincides with hydrological loading in the upper Mississippi embayment. We demonstrate that this loading, which results in geodetically observed surface deformation, induces stresses within the lithosphere that, although of small amplitude, modulate the ongoing seismicity of the New Madrid region. Correspondence between surface deformation, hydrological loading and seismicity rates at both annual and multi-annual timescales indicates that seismicity variations are the direct result of elastic stresses induced by the water load
Dynamics of Host Immune Response Development During Schistosoma mansoni Infection
Schistosomiasis is a disease of global significance, with severity and pathology directly related to how the host responds to infection. The immunological narrative of schistosomiasis has been constructed through decades of study, with researchers often focussing on isolated time points, cell types and tissue sites of interest. However, the field currently lacks a comprehensive and up-to-date understanding of the immune trajectory of schistosomiasis over infection and across multiple tissue sites. We have defined schistosome-elicited immune responses at several distinct stages of the parasite lifecycle, in three tissue sites affected by infection: the liver, spleen, and mesenteric lymph nodes. Additionally, by performing RNA-seq on the livers of schistosome infected mice, we have generated novel transcriptomic insight into the development of schistosome-associated liver pathology and fibrosis across the breadth of infection. Through depletion of CD11c+ cells during peak stages of schistosome-driven inflammation, we have revealed a critical role for CD11c+ cells in the co-ordination and regulation of Th2 inflammation during infection. Our data provide an updated and high-resolution account of how host immune responses evolve over the course of murine schistosomiasis, underscoring the significance of CD11c+ cells in dictating host immunopathology against this important helminth infection
Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor
Multiple TREX mRNA export complex subunits (e.g., THOC1, THOC2, THOC5, THOC6, THOC7) have now been implicated in neurodevelopmental disorders (NDDs), neurodegeneration and cancer. We previously implicated missense and splicing-defective THOC2 variants in NDDs and a broad range of other clinical features. Here we report 10 individuals from nine families with rare missense THOC2 variants including the first case of a recurrent variant (p.Arg77Cys), and an additional individual with an intragenic THOC2 microdeletion (Del-Ex37-38). Ex vivo missense variant testing and patient-derived cell line data from current and published studies show 9 of the 14 missense THOC2 variants result in
Perioperative mortality after hemiarthroplasty related to fixation method: A study based on the Australian Orthopaedic Association National Joint Replacement Registry
Background and purpose: The appropriate fixation method for hemiarthroplasty of the hip as it relates to implant survivorship and patient mortality is a matter of ongoing debate. We examined the influence of fixation method on revision rate and mortality.----- ----- Methods: We analyzed approximately 25,000 hemiarthroplasty cases from the AOA National Joint Replacement Registry. Deaths at 1 day, 1 week, 1 month, and 1 year were compared for all patients and among subgroups based on implant type.----- ----- Results: Patients treated with cemented monoblock hemiarthroplasty had a 1.7-times higher day-1 mortality compared to uncemented monoblock components (p < 0.001). This finding was reversed by 1 week, 1 month, and 1 year after surgery (p < 0.001). Modular hemiarthroplasties did not reveal a difference in mortality between fixation methods at any time point.----- ----- Interpretation: This study shows lower (or similar) overall mortality with cemented hemiarthroplasty of the hip
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