USING CONTINGENT VALUATION WITH RESPONDENT UNCERTAINTY TO ESTIMATE THE COSTS OF CLIMATE CHANGE PROGRAMS: AN APPLICATION TO CANADIAN LANDOWNERS

Using a survey of western Canadian agricultural landowners, we examine the cost and viability of two distinct afforestation options for carbon-uptake purposes. Responses to two separate, but most-likely related willingness to accept compensation questions are elicited using the contingent valuation method. Respondents then select the level of certainty with which they believe their responses were given. This paper provides a framework for estimation of the bivariate model with certainty and a modification of the model to incorporate uncertainty based on Li and Mattson's approach to preference uncertainty. While highly preliminary results are given for the bivariate model with certainty, applications of both models will be presented at the 2003 AAEA Meetings.Environmental Economics and Policy, Resource /Energy Economics and Policy,

Production of single-domain magnetite throughout life by sockeye salmon, Oncorhynchus nerka

Although single-domain particles of biogenic magnetite have been found in different species of pelagic fishes, nothing is known about when it is synthesized, or about whether the time during life when it is produced is correlated with the development of responses to magnetic field stimuli. We have investigated production of biogenic magnetite suitable for use in magnetoreception in different life stages of the sockeye salmon, Oncorhynchus nerka (Walbaum). Sockeye salmon were chosen because responses in orientation arenas to magnetic field stimuli have been demonstrated in both fry and smolt stages of this species. We found significant quantities of single-domain magnetite in connective tissue from the ethmoid region of the skull of adult (4-year-old) sockeye salmon. The ontogenetic study revealed an orderly increase in the amount of magnetic material in the same region of the skull but not in other tissues of sockeye salmon fry, yearlings and smolts. The physical properties of this material closely matched those of magnetite particles extracted from the ethmoid tissue of the adult fish. We suggest that single-domain magnetite particles suitable for use in magnetoreception are produced throughout life in the ethmoid region of the skull in sockeye salmon. Based on theoretical calculations, we conclude that there are enough particles present in the skulls of the fry to mediate their responses to magnetic field direction. By the smolt stage, the amount of magnetite present in the front of the skull is sufficient to provide the fish with a magnetoreceptor capable of detecting small changes in the intensity of the geomagnetic field. Other tissues of the salmon, such as the eye and skin, often contained ferromagnetic material, although the magnetizations of these tissues were usually more variable than in the ethmoid tissue. These deposits of unidentified magnetic material, some of which may be magnetite, appear almost exclusively in adults and so would not be useful in magnetoreception by young fish. We suggest that tissue from within the ethmoid region of the skull in pelagic fishes is the only site yet identified where magnetite suitable for use in magnetoreception is concentrated

Carbon Incentive Mechanisms and Land-Use Implications for Canadian Agriculture

This research examines effects of various factors on participation in agricultural tree plantations for economic, environmental, social and carbon-uptake purposes. Using survey data from 2000 mail surveys of Canadian farmers, a discrete choice random utility analysis is used to determine probability of farmers' participation and the corresponding mean willingness to accept a tree-planting program. Estimation results show that the required compensation for accepting a tree-planting program is higher than the compensation suggested by a normative approachEnvironmental Economics and Policy, Land Economics/Use,

Predicting the future of anti-tumor necrosis factor therapy

Tumor necrosis factor (TNF) antagonists are approved worldwide for the treatment of rheumatoid arthritis (RA). Clinical experience revealed that TNF-blocking therapy is effective for only approximately two thirds of patients, reflecting that there are 'responders' as well as 'nonresponders'. Given the destructive nature of RA, the risk of adverse effects, and considerable costs for therapy, there is a strong need to make predictions on success before the start of therapy. In the current issue of Arthritis Research & Therapy, Hueber and colleagues become the first to present a multi-parameter serum protein biomarker set that has predictive value prior to the start of anti-TNF treatment. Ultimately, this finding may contribute to a personalized form of medicine, whereby a specific therapy will be applied that is best suited to an individual patient

Combining DNA-microarray data in systemic lupus erythematosus

Systemic lupus erythematosus is a systemic, heterogeneous autoimmune disease. Understanding of its molecular complexity is incomplete and there is a need to identify new therapeutic targets and to optimize criteria for its diagnosis, assessment and prognosis. Recently, Arasappan and colleagues have described a new meta-analysis method that enables data analysis across different DNA-microarray datasets to identify genes and processes relevant to systemic lupus erythematosus. Their study provides a simple and valuable meta-analysis method for the selection of biomarkers and pathways in disease

Measuring the Fraction of Obscured Quasars by the Infrared Luminosity of Unobscured Quasars

Recent work has suggested that the fraction of obscured AGN declines with increasing luminosity, but it has been difficult to quantify this trend. Here, we attempt to measure this fraction as a function of luminosity by studying the ratio of mid-infrared to intrinsic nuclear bolometric luminosity in unobscured AGN. Because the mid-infrared is created by dust reprocessing of shorter wavelength nuclear light, this ratio is a diagnostic of f_obsc, the fraction of solid angle around the nucleus covered by obscuring matter. In order to eliminate possible redshift-dependences while also achieving a large dynamic range in luminosity, we have collected archival 24 micron MIPS photometry from objects with z~1 in the Sloan Digital Sky Survey (SDSS), the Great Observatories Origins Deep Survey (GOODS) and the Cosmic Evolution Survey (COSMOS). To measure the bolometric luminosity for each object, we used archival optical data supplemented by GALEX data. We find that the mean ratio of 24 microns to bolometric luminosity decreases by a factor of ~3 in the L_bol=10^44-3x10^47 ergs s^-1 range, but there is also a large scatter at constant L_bol. Using radiation transfer solutions for model geometries, we show how the IR/bolometric ratio relates to f_obsc and compare these values with those obtained obtained from samples of X-ray selected AGN. Although we find approximate agreement, our method indicates somewhat higher values of f_obsc, particularly in the middle range of luminosities, suggesting that there may be a significant number of heavily obscured AGN missed by X-ray surveys.Comment: ApJ, in press. 10 pages in emulateapj style, 4 figures, 3 table

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin

There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the growth of Bacillis subtilis and Staphyloccocus aureus. Mapping the genetic locus required for this activity revealed a putative natural product biosynthetic gene cluster, further defined to a six-gene operon named alb1-alb6. Bioinformatic analysis of the proteins encoded by alb1-6 predicted a hybrid non-ribosomal peptide synthetase-polyketide synthase (NRPS-PKS) assembly line (Alb4/5/6), tailoring enzymes (Alb2/3) and an export/resistance protein (Alb1), and suggested that the machinery assembled althiomycin or a related molecule. Althiomycin is a ribosome-inhibiting antibiotic whose biosynthetic machinery had been elusive for decades. Chromatographic and spectroscopic analyses confirmed that wild type S. marcescens produced althiomycin and that production was eliminated on disruption of the alb gene cluster. Construction of mutants with in-frame deletions of specific alb genes demonstrated that Alb2-Alb5 were essential for althiomycin production, whereas Alb6 was required for maximal production of the antibiotic. A phosphopantetheinyl transferase enzyme required for althiomycin biosynthesis was also identified. Expression of Alb1, a predicted major facilitator superfamily efflux pump, conferred althiomycin resistance on another, sensitive, strain of S. marcescens. This is the first report of althiomycin production outside of the Myxobacteria or Streptomyces and paves the way for future exploitation of the biosynthetic machinery, since S. marcescens represents a convenient and tractable producing organism