Oral Rabies Vaccination in North America: Opportunities, Complexities, and Challenges

Steps to facilitate inter-jurisdictional collaboration nationally and continentally have been critical for implementing and conducting coordinated wildlife rabies management programs that rely heavily on oral rabies vaccination (ORV). Formation of a national rabies management team has been pivotal for coordinated ORV programs in the United States of America. The signing of the North American Rabies Management Plan extended a collaborative framework for coordination of surveillance, control, and research in border areas among Canada, Mexico, and the US. Advances in enhanced surveillance have facilitated sampling of greater scope and intensity near ORV zones for improved rabies management decision-making in real time. The value of enhanced surveillance as a complement to public health surveillance was best illustrated in Ohio during 2007, where 19 rabies cases were detected that were critical for the formulation of focused contingency actions for controlling rabies in this strategically key area. Diverse complexities and challenges are commonplace when applying ORV to control rabies in wild meso-carnivores. Nevertheless, intervention has resulted in notable successes, including the elimination of an arctic fox (Vulpes lagopus) rabies virus variant in most of southern Ontario, Canada, with ancillary benefits of elimination extending into Quebec and the northeastern US. Progress continues with ORV toward preventing the spread and working toward elimination of a unique variant of gray fox (Urocyon cinereoargenteus) rabies in west central Texas. Elimination of rabies in coyotes (Canis latrans) through ORV contributed to the US being declared free of canine rabies in 2007. Raccoon (Procyon lotor) rabies control continues to present the greatest challenges among meso-carnivore rabies reservoirs, yet to date intervention has prevented this variant from gaining a broad geographic foothold beyond ORV zones designed to prevent its spread from the eastern US. Progress continues toward the development and testing of new bait-vaccine combinations that increase the chance for improved delivery and performance in the diverse meso-carnivore rabies reservoir complex in the US

A Conceptual Model for the Impact of Climate Change on Fox Rabies in Alaska, 1980–2010

The direct and interactive effects of climate change on host species and infectious disease dynamics are likely to initially manifest at latitudinal extremes. As such, Alaska represents a region in the United States for introspection on climate change and disease. Rabies is enzootic among arctic foxes (Vulpes lagopus) throughout the northern polar region. In Alaska, arctic and red foxes (Vulpes vulpes) are reservoirs for rabies, with most domestic animal and wildlife cases reported from northern and western coastal Alaska. Based on passive surveillance, a pronounced seasonal trend in rabid foxes occurs in Alaska, with a peak in winter and spring. This study describes climatic factors that may be associated with reported cyclic rabies occurrence. Based upon probabilistic modelling, a stronger seasonal effect in reported fox rabies cases appears at higher latitudes in Alaska, and rabies in arctic foxes appear disproportionately affected by climatic factors in comparison with red foxes. As temperatures continue a warming trend, a decrease in reported rabid arctic foxes may be expected. The overall epidemiology of rabies in Alaska is likely to shift to increased viral transmission among red foxes as the primary reservoir in the region. Information on fox and lemming demographics, in addition to enhanced rabies surveillance among foxes at finer geographic scales, will be critical to develop more comprehensive models for rabies virus transmission in the region

Aetiologies and risk factors for neonatal sepsis and pneumonia mortality among Alaskan infants.

We evaluated all fatal neonatal sepsis and pneumonia cases occurring in Alaska during 1992-2000. Risk factors were evaluated using a database of all births occurring during the study period. Of 32 cases, group B streptococcus (GBS) was isolated from 21% (all 7 days of age), non-GBS Gram-positive bacteria from 50% (53% <7 days of age), and Gram-negative infections from 38% (58% <7 days of age). Infants born at <37 weeks gestation accounted for 72% of cases and had an increased risk of GBS [rate ratio (RR) 9.1, 95% confidence interval (CI) 2.0-41] and non-GBS (RR 40, 95% CI 16-101) disease. Neonatal sepsis mortality has become an outcome concentrated among pre-term infants. Aetiologies include GBS during the early neonatal period, Candida spp. during the late neonatal period, and other bacteria during both periods

Influence of Lightweight Aggregate Concrete Materials on Building Energy Performance

Due to their porous nature, lightweight aggregates have been shown to exhibit thermal properties that are advantageous when used in building materials such as lightweight concrete, grout, mortar, and concrete masonry units. Limited data exist on the thermal properties of materials that incorporate lightweight aggregate where the pore system has not been altered, and very few studies have been performed to quantify the building energy performance of structures constructed using lightweight building materials in commonly utilized structural and building envelope components. In this study, several lightweight concrete and masonry building materials were tested to determine the thermal properties of the bulk materials, providing more accurate inputs to building energy simulation than have previously been used. These properties were used in EnergyPlus building energy simulation models for several types of commercial structures for which materials containing lightweight aggregates are an alternative commonly considered for economic and aesthetic reasons. In a simple model, use of sand lightweight concrete resulted in prediction of 15–17% heating energy savings and 10% cooling energy savings, while use of all lightweight concrete resulted in prediction of approximately 35–40% heating energy savings and 30% cooling energy savings. In more complex EnergyPlus reference models, results indicated superior thermal performance of lightweight aggregate building materials in 48 of 50 building energy simulations. Predicted energy savings for the five models ranged from 0.2% to 6.4%

Influence of Lightweight Aggregate Concrete Materials on Building Energy Performance

Due to their porous nature, lightweight aggregates have been shown to exhibit thermal properties that are advantageous when used in building materials such as lightweight concrete, grout, mortar, and concrete masonry units. Limited data exist on the thermal properties of materials that incorporate lightweight aggregate where the pore system has not been altered, and very few studies have been performed to quantify the building energy performance of structures constructed using lightweight building materials in commonly utilized structural and building envelope components. In this study, several lightweight concrete and masonry building materials were tested to determine the thermal properties of the bulk materials, providing more accurate inputs to building energy simulation than have previously been used. These properties were used in EnergyPlus building energy simulation models for several types of commercial structures for which materials containing lightweight aggregates are an alternative commonly considered for economic and aesthetic reasons. In a simple model, use of sand lightweight concrete resulted in prediction of 15–17% heating energy savings and 10% cooling energy savings, while use of all lightweight concrete resulted in prediction of approximately 35–40% heating energy savings and 30% cooling energy savings. In more complex EnergyPlus reference models, results indicated superior thermal performance of lightweight aggregate building materials in 48 of 50 building energy simulations. Predicted energy savings for the five models ranged from 0.2% to 6.4%

Short report: Molecular genetic characterization of an unusually severe case of hydatid disease in Alaska caused by the cervid strain of Echinococcus granulosusi

Distinct Echinococcus granulosus life cycle patterns have been described in North America: domestic and sylvatic. Gene sequences of the sylvatic E. granulosus indicate that it represents a separate variant. Case-based data have suggested that the course of sylvatic disease is less severe than that of domestic disease. which led to the recommendation to treat cystic echinococcosis patients in the Arctic by careful medical management rather than by aggressive surgery. We recently reported the first two documented E. granalosus human cases in Alaska with accompanying severe sequelae. Here we describe the results of molecular genetic analysis of the cyst material of one of the subjects that supported identification of the parasite as the sylvatic (cervid) strain and not the domestic (common sheep strain), which was initially thought to be implicated in these unusually severe Alaskan cases

An environment to integrate CAD tools used in education

Μη διαθέσιμη περίληψηNot available summarizationPresented on