92 research outputs found
Prediction of prostate cancer Gleason score upgrading from biopsy to radical prostatectomy using pre-biopsy multiparametric MRI PIRADS scoring system
Prognostic relevance of number and bilaterality of positive surgical margins after radical prostatectomy
Item does not contain fulltextPURPOSE: Positive surgical margin (PSM) status following radical prostatectomy (RP) is a well-established prognostic factor. The aim of the present study is to evaluate whether number of PSMs or bilaterality of PSMs might have prognostic significance for biochemical recurrence (BCR) in the population with a PSM status following RP. METHODS: We evaluated 1,395 RP pathology reports from our center between 1980 and 2006. All patients who underwent (neo)-adjuvant therapy were excluded, leaving a cohort of 1,009 patients, with 249 (24.7%) subjects having a PSM at RP of whom 29.4% had multiple PSMs (>/= 2 sites), while 13.6% had bilateral PSMs. Median follow-up was 40 months (range 0-258 months). We used BCR-free survival as the primary study outcome. BCR was defined as any rise in PSA above or equal to 0.2 ng/ml. RESULTS: Of patients with a PSM status, 41% (95% CI: 33-49%) developed BCR within 5 years, compared to 12% (95% CI: 9-15%) in the population without a PSM. Multivariable analysis identified PSA at diagnosis and RP Gleason score as independent predictive factors for BCR. Increasing number and/or bilaterality of PSM did not lead to significant higher rates of BCR. CONCLUSION: In patients with a PSM, the number of positive sites or bilaterality of PSM status does not add prognostic information for risk of BCR. Survival curve slopes were different for patients with bilateral PSM, showing a significant tendency to progress to BCR earlier during follow-up than patients with unilateral PSM.1 februari 201
EO7 MRI use prior to prostate biopsy in a German tertiary care centre: A plea for standardization
Strategische Aspekte einer Modernisierung des öffentlichen Dienstes - Zum Bedarf einer konzeptionellen Gesamtsteuerung von Management- entwicklungen
Vergleich von Elastographie-gezielten und systematischen Biopsien mit dem Prostatektomie-Präparat zur Vorhersage des Gleason Grads
Vergleich von Elastographie-gezielten und systematischen Biopsien mit dem Prostatektomie-Präparat zur Vorhersage des Gleason Grads
484 COMPARISON OF METHYLATION PATTERNS BETWEEN PRIMARY AND RECURRENT NON-MUSCLE INVASIVE BLADDER CANCER
Eingeschränkter diagnostischer und therapeutischer Zusatznutzen der Bildgebung der unteren Extremität bei der Ganzkörper-68Ga-PSMA PET/CT
1081 OPEN RADICAL PROSTATECTOMY (ORP) PERFORMED BY LOW VOLUME SURGEONS PREDISPOSES TO HIGHER RATES OF VENOUS THROMBOSIS (VT) AND PULMONARY EMBOLISM (PE)
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