Analyzing shell structure from Babylonian and modern times

We investigate ``shell structure'' from Babylonian times: periodicities and beats in computer-simulated lunar data corresponding to those observed by Babylonian scribes some 2500 years ago. We discuss the mathematical similarity between the Babylonians' recently reconstructed method of determining one of the periods of the moon with modern Fourier analysis and the interpretation of shell structure in finite fermion systems (nuclei, metal clusters, quantum dots) in terms of classical closed or periodic orbits.Comment: LaTeX2e, 13pp, 8 figs; contribution to 10th Nuclear Physics Workshop "Marie and Pierre Curie", 24 - 28 Sept. 2003, Kazimierz Dolny (Poland); final version accepted for J. Mod. Phys.

Diffuse glioma growth: a guerilla war

In contrast to almost all other brain tumors, diffuse gliomas infiltrate extensively in the neuropil. This growth pattern is a major factor in therapeutic failure. Diffuse infiltrative glioma cells show some similarities with guerilla warriors. Histopathologically, the tumor cells tend to invade individually or in small groups in between the dense network of neuronal and glial cell processes. Meanwhile, in large areas of diffuse gliomas the tumor cells abuse pre-existent “supply lines” for oxygen and nutrients rather than constructing their own. Radiological visualization of the invasive front of diffuse gliomas is difficult. Although the knowledge about migration of (tumor)cells is rapidly increasing, the exact molecular mechanisms underlying infiltration of glioma cells in the neuropil have not yet been elucidated. As the efficacy of conventional methods to fight diffuse infiltrative glioma cells is limited, a more targeted (“search & destroy”) tactic may be needed for these tumors. Hopefully, the study of original human glioma tissue and of genotypically and phenotypically relevant glioma models will soon provide information about the Achilles heel of diffuse infiltrative glioma cells that can be used for more effective therapeutic strategies